Diferencia entre revisiones de «Bupropion toxicity»

(Created page with "==Background== *Inhibits reuptake of norepinephrine and dopamine *Toxicity occurs with ingestion of >450mg/d ==Clinical Features== #Agitation #Dizziness #Tremor #N/V #Drowsiness...")
 
(hyperlink to seizure treatment page)
Línea 17: Línea 17:
#GI decontamination
#GI decontamination
##Consider whole-bowel irrigation for sustained-release formulations
##Consider whole-bowel irrigation for sustained-release formulations
#Seizure Treatment
#[[Seizure#Treatment|Seizure Treatment]]
##Benzos are 1st line
##Benzos are 1st line
##Barbs are 2nd line
##Barbs are 2nd line

Revisión del 12:43 7 feb 2014

Background

  • Inhibits reuptake of norepinephrine and dopamine
  • Toxicity occurs with ingestion of >450mg/d

Clinical Features

  1. Agitation
  2. Dizziness
  3. Tremor
  4. N/V
  5. Drowsiness
  6. Tachycardia
  7. Seizure
    1. May develop in isolation from other symptoms
    2. Develops within first 1-4hr for regular-release, up to 8hr for delayed release forms

Treatment

  1. GI decontamination
    1. Consider whole-bowel irrigation for sustained-release formulations
  2. Seizure Treatment
    1. Benzos are 1st line
    2. Barbs are 2nd line

Disposition

  • Consider discharge if asymptomatic after 8hr for regular-release ingestions

Source

  • Tintinalli
Obtenido de «https://www.wikem.org/w/index.php?title=Bupropion_toxicity&oldid=16885»