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==Background== | ==Background== | ||
*Nutritional deficiency of Vitamin C (Ascorbic acid) | |||
*Vitamin C is typically foundin fruits and vegetables. | |||
*Vitamin C is a cofactor for hydroxylation of proline and lysine amino acids in procollagen molecules, which is required for cross-linking collagen's triple helix. | |||
*Scurvy therefore leads to unstable collagen and collagen fragility. | |||
**leaking of vascular structures | **leaking of vascular structures | ||
***gingival bleeding | ***gingival bleeding | ||
***petechiae | ***petechiae | ||
***easy bruising | ***easy bruising | ||
*Vitamin C is also required for the disulfide bonding in hair leading to corkscrew appearance of hair. | |||
==Clinical Features== | ==Clinical Features== | ||
*Gingival bleeding | [[File:Corkscrew hair.png|thumb|Corkscrew hair in a patient with scurvy.]] | ||
[[File:Petechiae.png|thumb|Petechiae in a patient with scurvy.]] | |||
[[File: Scruvy_-_Easy_bruising.png |thumb|Bruising in a patient with scurvy.]] | |||
[[File: Gingival_bleeding.png |thumb|Gingival bleeding in a patient with scurvy.]] | |||
*[[Gingival bleeding]] | |||
*Easy bruising | *Easy bruising | ||
*Petechiae | *[[Petechiae]] | ||
*Corkscrew hair | *Corkscrew hair | ||
==Differential Diagnosis== | ==Differential Diagnosis== | ||
Revisión del 13:52 7 feb 2016
Background
- Nutritional deficiency of Vitamin C (Ascorbic acid)
- Vitamin C is typically foundin fruits and vegetables.
- Vitamin C is a cofactor for hydroxylation of proline and lysine amino acids in procollagen molecules, which is required for cross-linking collagen's triple helix.
- Scurvy therefore leads to unstable collagen and collagen fragility.
- leaking of vascular structures
- gingival bleeding
- petechiae
- easy bruising
- leaking of vascular structures
- Vitamin C is also required for the disulfide bonding in hair leading to corkscrew appearance of hair.
Clinical Features
- Gingival bleeding
- Easy bruising
- Petechiae
- Corkscrew hair
Differential Diagnosis
Diagnosis
Guided by clinical suspicion but confirmed with laboratory analysis of vitamin C levels.
Management
Vitamin C supplementation.
Disposition
See Also
External Links
References
- Kluesner, Nicholas and Miller, daniel. “Scurvy: Malnourishment in the land of the plenty.” The journal of emergency medicine. Vol 46. no 4. pages 530-532. 2014.
- Maltos, andre, et al. “Scurvy in a patient with AIDS: case report.” Revista de sociedade brasileira de medicina tropical 44(1): 122-123. 2011.