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==Clinical Features==
==Clinical Features==
*[[Febrile]] >14dys (without clear source)
*Original definition<ref name="Kaya">Kaya A, Ergul N, Kaya SY, et al. The management and the diagnosis of fever of unknown origin. Expert Rev Anti Infect Ther. 2013 Aug;11(8):805-15.</ref>
**Fever >38.3 C on several occasions
**Lasting for at least 3 weeks
**No clear diagnosis after 1 week inpatient workup
*Newer definition<ref>Durack DT, Street AC. Fever of unknown origin--reexamined and redefined. Curr Clin Top Infect Dis. 1991;11:35-51.</ref> - "Prolonged fever" with:
**3 outpatient visits without identifying a cause '''or'''
**3 inpatient days without identifying a cause '''or'''
**1 week of “intelligent and invasive” ambulatory investigation


==Differential Diagnosis==
==Differential Diagnosis==
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==References==
==References==
<References/>


[[Category:Peds]]
[[Category:Peds]]

Revisión del 05:55 10 ago 2015

Background

Clinical Features

  • Original definition[1]
    • Fever >38.3 C on several occasions
    • Lasting for at least 3 weeks
    • No clear diagnosis after 1 week inpatient workup
  • Newer definition[2] - "Prolonged fever" with:
    • 3 outpatient visits without identifying a cause or
    • 3 inpatient days without identifying a cause or
    • 1 week of “intelligent and invasive” ambulatory investigation

Differential Diagnosis

  • INFECTION
  • COLLAGEN VASCULAR
  • MALIGNANCY
    • Leukemia
    • Lymphoma
    • Neuroblastoma
    • Wilm's tumor
  • DRUG INDUCED
    • Antibiotics
    • Anticonvulsants
    • Anti TB
    • Procainamide
    • Quinidine
    • Serum sickness
  • MISC

Diagnosis

  • Clinical (preliminary) diagnosis

Management

Disposition

  • Frequently admitted for workup

See Also

References

  1. Kaya A, Ergul N, Kaya SY, et al. The management and the diagnosis of fever of unknown origin. Expert Rev Anti Infect Ther. 2013 Aug;11(8):805-15.
  2. Durack DT, Street AC. Fever of unknown origin--reexamined and redefined. Curr Clin Top Infect Dis. 1991;11:35-51.