Diferencia entre revisiones de «Doxylamine»
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Revisión actual - 21:57 20 mar 2026
Administration
- Type: Antihistamine
- Dosage Forms:
- Routes of Administration: oral
- Common Trade Names: Unisom
Adult Dosing
- Rhinitis: 7.5-12.5mg PO q4-6h
- Insomnia: 25-50mg PO
- Nausea in pregnancy/hyperemesis gravidarum: 12.5mg q6-8hrs (often used in combination with pyridoxine)
Pediatric Dosing
Not recommended for children <12 yo due to tendency to paradoxical reactions
- 2-6yo: 1.9 to 3.125 mg q4-6h
- 6-12 yo: 3.75 to 6.25 mg q4-6h
Special Populations
- Pregnancy Rating: A
- Lactation risk: Infant risk cannot be ruled out
- Renal dosing: no adjustment
- Hepatic dosing: no adjustment
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
Common
- Somnolence
Pharmacology
- Half-life: 10-18h
- Metabolism: Hepatic - CYP450
- Excretion: Urine
Mechanism of Action
- H1-histamine blocker
Comments
Indications by Condition
The following table is automatically generated from disease/condition pages across WikEM.
| Indication | Dose | Context | Route | Population |
|---|---|---|---|---|
| Hyperemesis gravidarum | 12.5 mg q6-8hr | 1st line antiemetic (add to B6) | PO | Adult |