Diferencia entre revisiones de «Lysergic acid diethylamide toxicity»
(Ddx) |
|||
| Línea 43: | Línea 43: | ||
Delirium | Delirium | ||
==Disposition== | ==Workup, Management, and Disposition== | ||
==See Also== | ==See Also== | ||
Revisión del 19:11 28 may 2015
Background
d-lysergic acid diethylamide, more commonly known as LSD, was first synthesized in 1938 by the chemist Albert Hofmann in efforts to chemically create a blood stimulant.[1]In 1943, Hoffman accidently ingested LSD for the first time, discovering its hallucinagenic properties, reportedly seeing "an uninterrupted stream of fantastic pictures, extraordinary shapes with intense, kaleidoscopelike play of colors." LSD became very popular in the 1960's and 1970's, making it a very important part of the "counterculture" movement, encouraging participants to "turn on, tune in, drop out."
Mechanism
Serotonin like agent
Pharmacology
most potent psychoactive drug. Doses of 1 to 1.5 μg/kg produce psychedelic effects. The typical dose taken for an acid “trip” is approximately 25 to 100 μg. Time to onset Trip lasting Distribution Tachyphylaxis
Effects
Trip and what it looks like Good trip Bad trip Medical considerations
Differential Diagnosis
Serotonin-Like Agents
LSD Psilocybin and psilocin dimethyltryptamine (DMT) and 5-methoxy- dimethyltryptamine (5-MeO-DMT) Hawaiian baby woodrose (Argyreia nervosa), Hawaiian woodrose (Merremia tuberosa), morning glory (Ipomoea violacea), and olili- uqui (Rivea corymbosa)
Enactogens
Designer amphetamines - MDMA, Bath Salts, Ecstasy Mescaline
Dissociative Agents
PCP Ketamine Dextromethotphan
Plant-based Hallucinogenics
Marijuana Salvia Absinthe Isoxazole Mushrooms
Psychiatric Illnesses
Schizophrenia Schizo-affective disorder Dementia Delirium
Workup, Management, and Disposition
See Also
External Links
References
- ↑ Hofmann A. "Die Geschichte des LSD-25". Triangel Sandoz Zeitschrift fur Medizinische Wissenschaften. 1955;2(3):117-24. (as cited in Ott J. Pharmacotheon. 1993. pg 123.)