Acetaminophen

General

• Type: Antipyretic
• Dosage Forms: IV; PO; PR
• Common Trade Names: Tylenol

Adult Dosing

General

• PO
  • Immediate-release
    • Regular strength: 650 mg q4-6 hours
    • Extra strength: 1000 mg q6 hours
  • Extended-release: 1300 mg q8 hours
• Rectal: 650 mg q4-6 hours
• IV:
  • <50 kg: 15 mg/kg q6 hours or 12.5 mg/kg q4 hours
  • ≥50 kg: 650 mg q4 hours or 1000 mg q6 hours
• Maximum daily dose: 4g

Pediatric Dosing

• 15 mg/kg/dose q6 hours

Weight (kg)	Weight (lbs)	Age	Dosage (mg)
2.7-5.3	6-11	0-3 mo	40
5.4-8.1	12-17	4-11 mo	80
8.2-10.8	18-23	1-2 y	120
10.9-16.3	24-35	2-3 y	160
16.4-21.7	36-47	4-5 y	240
21.8-27.2	48-59	6-8 y	320
27.3-32.6	60-71	9-10 y	400
32.7-43.2	72-95	11 y	480

Special Populations

• Pregnancy Rating:
• Lactation:
• Renal Dosing
  • Adult
  • Pediatric
• Hepatic Dosing
  • Adult
  • Pediatric

Contraindications

• Allergy to class/drug

Adverse Reactions

Serious

• Acetaminophen (tylenol) toxicity

Warnings

• When calculating maximum daily dose consider all sources of acetaminophen
• Be careful that the dose in milligrams and milliliters is not confused

Pharmacology

• Half-life:
• Metabolism:
• Excretion:
• Mechanism of Action:

See Also

• Acetaminophen (tylenol) toxicity