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==Background==
==Background==
#an ultrashort-acting sedative alkylphenol derivative that induces deep sedation
#Rapid onset (90-100 seconds) and short duration (2-8 minute)
#rapid onset (90-100 seconds) and short duration (2-8 minute half-life)


==Contraindications==
==Contraindications==
#allergy to soy or eggs
#Allergy to soy or eggs
#hypotension
#Hypotension
#aortic stenosis
#Aortic stenosis


===Higher Risk===
===Higher Risk===
#Patients >55 years old
#Pts >55 yr
#Debilitated patients
#Debilitated patients
#Patients with significant underlying illness (i.e. ASA physical status score III or IV)
#Pts w/ significant underlying illness (i.e. ASA physical status score III or IV)
^Optimize volume status before administration  
##Optimize volume status before administration  


==Side Effects==
==Side Effects==
#Respiratory depression
#Respiratory depression
#Transient hypotension
#Transient hypotension
#Pain at injection site (inject lidocaine IV first)
#Pain at injection site (inject lidocaine 20-40mg IV first)


==Dose==
==Dose==
#induction = 1mg/kg IV, followed by 0.5mg/kg every 2-3 minutes as needed
#Induction = 0.5-1mg/kg IV, followed by 0.5mg/kg every 2-3 minutes as needed
#Small incremental doses (10-30mg) can slowly be administered to effect
#Small incremental doses (10-30mg) can slowly be administered to effect


===Adjunctive medications===
===Adjunctive medications===
#fentanyl or morphine (propofol does not provide analgesia)
#Fentanyl or morphine (propofol does not provide analgesia)
#NS for transient hypotension
#NS for transient hypotension
#Lidocaine flush (to reduce injection pain)
#Lidocaine flush (to reduce injection pain)


==Pediatric Population==
==Pediatric Population==
#Safe for procedural sedation in pediatric patients.  Same dosing.
#Same dosing


==See Also==
==See Also==

Revisión del 19:05 11 jul 2011

Background

  1. Rapid onset (90-100 seconds) and short duration (2-8 minute)

Contraindications

  1. Allergy to soy or eggs
  2. Hypotension
  3. Aortic stenosis

Higher Risk

  1. Pts >55 yr
  2. Debilitated patients
  3. Pts w/ significant underlying illness (i.e. ASA physical status score III or IV)
    1. Optimize volume status before administration

Side Effects

  1. Respiratory depression
  2. Transient hypotension
  3. Pain at injection site (inject lidocaine 20-40mg IV first)

Dose

  1. Induction = 0.5-1mg/kg IV, followed by 0.5mg/kg every 2-3 minutes as needed
  2. Small incremental doses (10-30mg) can slowly be administered to effect

Adjunctive medications

  1. Fentanyl or morphine (propofol does not provide analgesia)
  2. NS for transient hypotension
  3. Lidocaine flush (to reduce injection pain)

Pediatric Population

  1. Same dosing

See Also

Procedural Sedation