Diferencia entre revisiones de «Unfractionated heparin»
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==Adult Dosing== | ==Adult Dosing== | ||
===Thromboembolism=== | |||
*Bolus: 80 units/kg IV x 1 (MAX: 5,000 units) | |||
*Then drip: 18 units/kg/h IV (MAX: 1,000 units/h) | |||
*Adjust dose to target aPTT levels based on nomogram | |||
===PCI=== | |||
#See: | #See: | ||
##[[DVT]] | ##[[DVT]] | ||
Revisión del 23:17 17 ene 2015
General
- Type:
- Dosage Forms: IV, SC
- Common Trade Names:
Adult Dosing
Thromboembolism
- Bolus: 80 units/kg IV x 1 (MAX: 5,000 units)
- Then drip: 18 units/kg/h IV (MAX: 1,000 units/h)
- Adjust dose to target aPTT levels based on nomogram
PCI
Pediatric Dosing
Special Populations
- Pregnancy Rating: Safe in pregnancy
- Lactation:
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Contraindications
- Allergy to class/drug
- 33% of pts develop some form of bleeding complication; 2-6% develop major bleeding
- Heparin-Induced Thrombocytopenia
- See HIT (Heparin-Induced Thrombocytopenia)
Risk Factors for Major Bleeding Complication
- Recent surgery or trauma
- Renal failure
- Alcoholism
- Malignancy
- Liver failure
- Concurrent use of warfarin, fibrinolytics, steroids, or antiplatelet drugs
Pharmacology
- Half-life:
- Metabolism:
- Excretion:
- Mechanism of Action:
- Binds to and activates antithrombin which in turns inactivates factor Xa and thrombin
- Anticoagulation effect lasts up to 3hr after stopping infusion
- Must give IV (not subq) for acute thromboembolic disease
- Unpredictable anticoagulation effect
- Must monitor w/ PTT; therapeutic range is 1.5-2.5x normal value