Diferencia entre revisiones de «Norepinephrine»
(Created page with "==General== *Type: Vasopressors *Dosage Forms: *Common Trade Names: ==Adult Dosing== ==Pediatric Dosing== ==Special Populations== *Drug Ratings in Pregnancy|Pregnanc...") |
Sin resumen de edición |
||
| Línea 5: | Línea 5: | ||
==Adult Dosing== | ==Adult Dosing== | ||
===Dosing=== | |||
''Based on Glomerular Filtration Rate [GFR (ml/min)]'' | |||
*<10: 0.2mcg/kg/min | |||
*10-40: 0.3mcg/kg/min | |||
*>40-50: 0.4mcg/kg/min | |||
*For CVVHD: dose at 0.4mcg/kg/min | |||
*For HD: dose 0.2mcg/kg/min | |||
===Rate of Titration=== | |||
*Q2-5 min | |||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
| Línea 22: | Línea 33: | ||
==Adverse Reactions== | ==Adverse Reactions== | ||
*If extravasation occurs use phentolamine 0.1 to 0.2 mg/kg (maximum dose 10 mg) subcutaneous in affected site<ref>ZUCKER G. et al. Treatment of shock and prevention of ischemic necrosis with levarterenol-phentolamine mixtures. Circulation. 1960 Nov;22:935-7.</ref><ref>PELNER L. et al. The problem of levarterenol (levophed) extravasation an experimental study.. Am J Med Sci. 1958 Dec;236(6):755-66</ref> | |||
**Consult plastic/general surgery service to follow the patient and eval for need for intervention<ref>Emcrit peripheral vasopressors http://emcrit.org/podcasts/peripheral-vasopressors-extravasation/</ref> | |||
===Serious=== | ===Serious=== | ||
| Línea 31: | Línea 45: | ||
*Excretion: | *Excretion: | ||
*Mechanism of Action: | *Mechanism of Action: | ||
===Primary Receptor=== | |||
*α1 >> β1 | |||
===Relative Effects=== | |||
*↑↑↑SVR | |||
*↑HR | |||
*↑SV | |||
==Notes== | |||
More potent vasoconstrictor than dopamine and phenylephrine. | |||
===Indication=== | |||
*Septic shock (1st line) | |||
*Cardiogenic shock: | |||
**If marked hypotension (SBP <70) | |||
**If used with dobutamine | |||
==See Also== | ==See Also== | ||
Revisión del 14:07 20 dic 2014
General
- Type: Vasopressors
- Dosage Forms:
- Common Trade Names:
Adult Dosing
Dosing
Based on Glomerular Filtration Rate [GFR (ml/min)]
- <10: 0.2mcg/kg/min
- 10-40: 0.3mcg/kg/min
- >40-50: 0.4mcg/kg/min
- For CVVHD: dose at 0.4mcg/kg/min
- For HD: dose 0.2mcg/kg/min
Rate of Titration
- Q2-5 min
Pediatric Dosing
Special Populations
- Pregnancy Rating:
- Lactation:
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Contraindications
- Allergy to class/drug
Adverse Reactions
- If extravasation occurs use phentolamine 0.1 to 0.2 mg/kg (maximum dose 10 mg) subcutaneous in affected site[1][2]
- Consult plastic/general surgery service to follow the patient and eval for need for intervention[3]
Serious
Common
Pharmacology
- Half-life:
- Metabolism:
- Excretion:
- Mechanism of Action:
Primary Receptor
- α1 >> β1
Relative Effects
- ↑↑↑SVR
- ↑HR
- ↑SV
Notes
More potent vasoconstrictor than dopamine and phenylephrine.
Indication
- Septic shock (1st line)
- Cardiogenic shock:
- If marked hypotension (SBP <70)
- If used with dobutamine
See Also
Sources
- ↑ ZUCKER G. et al. Treatment of shock and prevention of ischemic necrosis with levarterenol-phentolamine mixtures. Circulation. 1960 Nov;22:935-7.
- ↑ PELNER L. et al. The problem of levarterenol (levophed) extravasation an experimental study.. Am J Med Sci. 1958 Dec;236(6):755-66
- ↑ Emcrit peripheral vasopressors http://emcrit.org/podcasts/peripheral-vasopressors-extravasation/