Diferencia entre revisiones de «Cabergoline»
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==Indications== | |||
*Hyperprolactinemia (may be idiopathic or due to prolactinoma) | |||
==Administration== | ==Administration== | ||
*Type: Dopamine Agonist | *Type: Dopamine Agonist | ||
*Dosage Forms: Tab 0.5mg | *Dosage Forms: Tab 0.5mg | ||
*Routes of Administration: Oral | *Routes of Administration: Oral | ||
*Common Trade Names: | *Common Trade Names: DOSTINEX | ||
==Adult Dosing== | ==Adult Dosing== | ||
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==Pharmacology== | ==Pharmacology== | ||
*Half-life: 63-69 | *Half-life: 63-69 hours | ||
*Metabolism: Liver | *Metabolism: Liver | ||
*Excretion: Feces 60%, urine 22% (<4% unchanged) | *Excretion: Feces 60%, urine 22% (<4% unchanged) | ||
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==Mechanism of Action== | ==Mechanism of Action== | ||
*Stimulates dopamine D2 receptors to inhibit prolactin secretion | *Stimulates dopamine D2 receptors to inhibit prolactin secretion | ||
==See Also== | ==See Also== | ||
==References== | ==References== | ||
Revisión actual - 17:25 16 jun 2021
Indications
- Hyperprolactinemia (may be idiopathic or due to prolactinoma)
Administration
- Type: Dopamine Agonist
- Dosage Forms: Tab 0.5mg
- Routes of Administration: Oral
- Common Trade Names: DOSTINEX
Adult Dosing
Hyperprolactinemia
- 0.25-1 mg PO 2x/wk
- Start 0.25mg 2x/wk, increase q4wk by 0.25mg 2x/wk
- Max: 1 mg 2x/wk
Pediatric Dosing
Safety/efficacy not established in pediatric patients
Special Populations
- Pregnancy Rating: B: No teratogenicity at 55x MRHD
- Lactation risk: Avoid use while breastfeeding
Renal Dosing
- Adult: Not defined
- Pediatric: Unavailable
Hepatic Dosing
- Adult:
- Child-Pugh Class C: Caution advised
- Pediatric: Unavailable
Contraindications
- Allergy to class/drug
- Hypersensitivity to ergot derivatives
- Cardiac valvular fibrosis
- Pericardial fibrosis
- Pulmonary fibrosis
- Retroperitoneal fibrosis
- Hypertension, uncontrolled
- Breastfeeding
- Hepatic impairment
Adverse Reactions
Serious
- Hypotension, orthostatic
- Valvulopathy
- Pleural effusion
- Pulmonary fibrosis, Pericardial fibrosis, retroperitoneal fibrosis
- Depression, aggressive behavior, psychosis
Common
- Nausea, Vomiting, Vertigo
- Headache, Dizziness
- Constipation, abdominal pain, diarrhea
- Asthenia, paresthesia
- Fatigue, Somnolence
- Dyspepsia
- Anxiety, compulsive behaviors
- Hot flashes, breast pain
- Xerostomia
Pharmacology
- Half-life: 63-69 hours
- Metabolism: Liver
- Excretion: Feces 60%, urine 22% (<4% unchanged)
Mechanism of Action
- Stimulates dopamine D2 receptors to inhibit prolactin secretion