Diferencia entre revisiones de «Diazepam»

Revisión actual - 21:56 20 mar 2026

General

Type: Benzodiazepines
Dosage Forms:
Common Trade Names: Valium

Adult Dosing

Anxiety
- PO: 2 - 10 mg 2-4 times daily

Muscle spasm
- PO: 2 - 10 mg 2-4 times daily

Sedation in ICU
- IV: Loading dose: 5 - 10 mg, Maintenance dose: 0.03 - 0.1 mg/kg every 30 minutes to 6 hours

Pediatric Dosing

Special Populations

Pregnancy Rating: D
Lactation: Diazepam and metabolites are present in breast milk
Renal Dosing
- Adult
  - Not defined
- Pediatric
  - Not defined
Hepatic Dosing
- Adult
  - Not defined, use with caution, do not used oral tablets in severe hepatic impairment
- Pediatric
  - Not defined, use with caution, do not used oral tablets in severe hepatic impairment

Contraindications

Allergy to class/drug
severe hepatic impairment

Adverse Reactions

Serious

Respiratory/CNS depression
Hypotension
paradoxical CNS stimulation

Common

drowsiness
disinhibition
ataxia

Pharmacology

Half-life: 30-60 hours
Metabolism: Liver
Excretion: Urine
Mechanism of Action: GABA agonist

Indications by Condition

The following table is automatically generated from disease/condition pages across WikEM.

Indication	Dose	Context	Route	Population
Carbamate poisoning	5-10mg IV	Seizure control	IV	Adult
Carbamate poisoning	0.2-0.5mg/kg IV	Seizure control	IV	Pediatric
Cocaine toxicity	5-10mg IV q5min PRN agitation	First-line for agitation, seizures, and sympathetic excess	IV	Adult
Delirium tremens	10mg x2, then 20mg x3, then 40mg x3 q5-10min (max 200mg)	First-line escalating dose protocol for DTs	IV	Adult
Ethanol withdrawal	5-10 mg IV q5-10min, increase by 10 mg increments until desired effect	1st line benzodiazepine (long-acting)	IV	Adult
Organophosphate toxicity	5-10 mg	Seizure control	IV	Adult
Organophosphate toxicity	0.2-0.5 mg/kg	Seizure control	IV	Pediatric
Vertigo	2.5-10 mg q6hr PRN	Benzodiazepine (vestibular suppressant)	PO	Adult

References

Diazepam: Drug information. UpToDate. www.uptodate.com. Accessed April 2, 2019.

Authors:

@@ Línea 5: / Línea 5: @@
 ==Adult Dosing==
+* Anxiety
+** PO: 2 - 10 mg 2-4 times daily
+* Muscle spasm
+** PO: 2 - 10 mg 2-4 times daily
+* Sedation in ICU
+** IV: Loading dose: 5 - 10 mg, Maintenance dose: 0.03 - 0.1 mg/kg every 30 minutes to 6 hours
 ==Pediatric Dosing==
 ==Special Populations==
-*[[Drug Ratings in Pregnancy|Pregnancy Rating]]:
+*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: D
-*Lactation:
+*Lactation: Diazepam and metabolites are present in breast milk
 *Renal Dosing
 **Adult
+*** Not defined
 **Pediatric
+*** Not defined
 *Hepatic Dosing
 **Adult
+*** Not defined, use with caution, do not used oral tablets in severe hepatic impairment
 **Pediatric
+*** Not defined, use with caution, do not used oral tablets in severe hepatic impairment
 ==Contraindications==
 *Allergy to class/drug
+* severe hepatic impairment
 ==Adverse Reactions==
 ===Serious===
+* Respiratory/CNS depression
+* Hypotension
+* paradoxical CNS stimulation
 ===Common===
+* drowsiness
+* disinhibition
+* ataxia
 ==Pharmacology==
-*Half-life:
+*Half-life: 30-60 hours
-*Metabolism:
+*Metabolism: Liver
-*Excretion:
+*Excretion: Urine
-*Mechanism of Action:
+*Mechanism of Action: GABA agonist
+==Indications by Condition==
+''The following table is automatically generated from disease/condition pages across WikEM.''
+{{#ask:[[Has DrugName::Diazepam]]
+ |?Has Indication=Indication
+ |?Has Dose=Dose
+ |?Has Context=Context
+ |?Has Route=Route
+ |?Has Population=Population
+ |format=table
+ |headers=plain
+ |mainlabel=-
+ |sort=Has Indication
+ |limit=50
+}}
 ==See Also==
 ==References==
 <references/>
+* Diazepam: Drug information. UpToDate. www.uptodate.com. Accessed April 2, 2019.
 [[Category:Pharmacology]]
+[[Category:Neurology]]