Diferencia entre revisiones de «Pyridoxine»
Sin resumen de edición |
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| (No se muestran 9 ediciones intermedias de 3 usuarios) | |||
| Línea 5: | Línea 5: | ||
==Adult Dosing== | ==Adult Dosing== | ||
*Seizures associated with overdose of [[INH]] or ingestion of [[gyromitra]] mushrooms <ref> Berger KJ, Guss DA. Mycotoxins revisited: Part II. J Emerg Med. 2005;28(2):175. </ref> <ref>Howland MA, “Antidotes in Depth: Pyridoxine,” Goldfrank's Toxicologic Emergencies, 10th ed, Flomenbaum NE, Goldfrank LR, Hoffman RS, et al, eds, New York, NY: McGraw-Hill Companies, Inc, 2015, 872-5.</ref> | ===[[Hyperemesis gravidarum]]=== | ||
*10-25mg q6-8hrs | |||
===[[Seizures]] associated with overdose of [[INH]] or ingestion of [[gyromitra]] mushrooms <ref> Berger KJ, Guss DA. Mycotoxins revisited: Part II. J Emerg Med. 2005;28(2):175. </ref> <ref>Howland MA, “Antidotes in Depth: Pyridoxine,” Goldfrank's Toxicologic Emergencies, 10th ed, Flomenbaum NE, Goldfrank LR, Hoffman RS, et al, eds, New York, NY: McGraw-Hill Companies, Inc, 2015, 872-5.</ref>=== | |||
*Known quantity ingested: Give IV pyridoxine 1:1 with amount ingested, up to 5 grams | |||
*Unknown quantity ingested: 5 grams | |||
*IV Infusion rate is 0.5 g/min until the seizures stop or the maximum dose is reached. Remainder of dose infused over 4 to 6 hours | |||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
===Seizures associated with overdose of [[INH]]=== | |||
*Known quantity ingested: Give IV pyridoxine 1:1 with amount ingested, up to 5 grams | |||
*Unknown quantity ingested: 70mg/kg up to 5 gm (adult dose) <ref>Minns, A. et al. Isoniazid-Induced Status Epilepticus in a Pediatric Patient After Inadequate Pyridoxine Therapy. Pediatric Emergency Care. 2010:26(5)380-381 </ref> | |||
*[[ | *Then give 1 gram IM q30min until total dose required reached<ref>Pyridoxine. www.Drugs.com. http://www.drugs.com/dosage/pyridoxine.html</ref> | ||
* | |||
===[[Gyromitra]] ingestion=== | |||
*70mg/kg initial dose | |||
==Special Populations== | ==Special Populations== | ||
| Línea 36: | Línea 41: | ||
*[[Antidotes]] | *[[Antidotes]] | ||
*[[INH]] | *[[INH]] | ||
*[[Vitamin deficiencies]] | |||
==References== | ==References== | ||
<references/> | <references/> | ||
[[Category:Pharmacology]] | [[Category:Pharmacology]] | ||
[[Category:FEN]] | |||
Revisión actual - 22:11 23 sep 2019
Administration
- Type: Water soluble vitamin
- Routes of Administration: Oral, IV/IM
- Common Trade Names: Vitamin B6
Adult Dosing
Hyperemesis gravidarum
- 10-25mg q6-8hrs
Seizures associated with overdose of INH or ingestion of gyromitra mushrooms [1] [2]
- Known quantity ingested: Give IV pyridoxine 1:1 with amount ingested, up to 5 grams
- Unknown quantity ingested: 5 grams
- IV Infusion rate is 0.5 g/min until the seizures stop or the maximum dose is reached. Remainder of dose infused over 4 to 6 hours
Pediatric Dosing
Seizures associated with overdose of INH
- Known quantity ingested: Give IV pyridoxine 1:1 with amount ingested, up to 5 grams
- Unknown quantity ingested: 70mg/kg up to 5 gm (adult dose) [3]
- Then give 1 gram IM q30min until total dose required reached[4]
Gyromitra ingestion
- 70mg/kg initial dose
Special Populations
- Pregnancy Rating: A
- Lactation risk: May inhibit lactation when given in high amounts
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
Common
Mechanism of Action
Comments
See Also
References
- ↑ Berger KJ, Guss DA. Mycotoxins revisited: Part II. J Emerg Med. 2005;28(2):175.
- ↑ Howland MA, “Antidotes in Depth: Pyridoxine,” Goldfrank's Toxicologic Emergencies, 10th ed, Flomenbaum NE, Goldfrank LR, Hoffman RS, et al, eds, New York, NY: McGraw-Hill Companies, Inc, 2015, 872-5.
- ↑ Minns, A. et al. Isoniazid-Induced Status Epilepticus in a Pediatric Patient After Inadequate Pyridoxine Therapy. Pediatric Emergency Care. 2010:26(5)380-381
- ↑ Pyridoxine. www.Drugs.com. http://www.drugs.com/dosage/pyridoxine.html