Diferencia entre revisiones de «Iodoquinol»
(Iodoquinol page) |
(Add peer-reviewed reference) |
||
| (No se muestran 5 ediciones intermedias de 4 usuarios) | |||
| Línea 1: | Línea 1: | ||
==Administration== | ==Administration== | ||
*Type: Amebicide | *Type: Amebicide<ref>Gonzalez ML, et al. Antiamoebic drugs for treating amoebic colitis. Cochrane Database Syst Rev. 2019;1:CD006085. PMID 30624763</ref> | ||
*Routes of Administration: Oral | *Routes of Administration: Oral | ||
*Common Trade Names: Aloquin; Yodoxin | *Common Trade Names: Aloquin; Yodoxin | ||
==Adult Dosing== | ==Adult Dosing== | ||
* | *650mg 3 times daily after meals for 20 days | ||
**Not to exceed 1.95 g daily | **Not to exceed 1.95 g daily | ||
===Indications by Disease=== | |||
{{#ask: [[Has DrugName::Iodoquinol]] [[Has Population::Adult]] | |||
|?Treats disease=Disease | |||
|?Has Dose=Dose | |||
|?Has Context=Context | |||
|format=table | |||
|limit=50 | |||
|mainlabel=- | |||
|headers=show | |||
|sort=Treats disease | |||
}} | |||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
*Children: 30- | *Children: 30-40mg/kg daily (maximum: 650mg per dose) in 3 divided doses for 20 days | ||
**Not to exceed 1.95 g daily | **Not to exceed 1.95 g daily | ||
===Indications by Disease=== | |||
{{#ask: [[Has DrugName::Iodoquinol]] [[Has Population::Pediatric]] | |||
|?Treats disease=Disease | |||
|?Has Dose=Dose | |||
|?Has Context=Context | |||
|format=table | |||
|limit=50 | |||
|mainlabel=- | |||
|headers=show | |||
|sort=Treats disease | |||
}} | |||
==Special Populations== | ==Special Populations== | ||
| Línea 22: | Línea 46: | ||
==Contraindications== | ==Contraindications== | ||
*Allergy to class/drug | *Allergy to class/drug, hypersensitivity to iodine and/or 8-hydroxyquinolones | ||
*Concerns with optic neuritis | *Concerns with optic neuritis | ||
*Concerns with peripheral neuropathy | *Concerns with peripheral neuropathy | ||
*Hepatic impairment | |||
*Renal impairment | |||
*Chronic diarrhea, especially in children | |||
==Adverse Reactions== | ==Adverse Reactions== | ||
===Serious=== | |||
* | *Peripheral neuropathy, Long-term (high-dose) | ||
* | *Optic atrophy, Long-term (high-dose) | ||
* | *Optic neuritis, Long-term (high-dose) | ||
===Common=== | |||
* | *Nausea/vomiting, diarrhea, cramps | ||
*Fever/chills | |||
* | *Pruritus, urticaria | ||
* | *Headache, dizziness | ||
* | |||
==Pharmacology== | ==Pharmacology== | ||
| Línea 44: | Línea 70: | ||
==Mechanism of Action== | ==Mechanism of Action== | ||
*Contact amebicide that works in the lumen of the intestine (unknown mechanism) | |||
==Comments== | ==Comments== | ||
==See Also== | ==See Also== | ||
*[[Parasitic diseases]] | |||
==References== | ==References== | ||
<UpToDate> | <UpToDate> | ||
[[Category: | [[Category:Pharmacology]] | ||
[[Category:ID]] | |||
Revisión actual - 10:18 22 mar 2026
Administration
- Type: Amebicide[1]
- Routes of Administration: Oral
- Common Trade Names: Aloquin; Yodoxin
Adult Dosing
- 650mg 3 times daily after meals for 20 days
- Not to exceed 1.95 g daily
Indications by Disease
| Disease | Dose | Context |
|---|---|---|
| Acute diarrhea | 650mg q 8hrs daily 20 days | Entamoeba, Luminal |
Pediatric Dosing
- Children: 30-40mg/kg daily (maximum: 650mg per dose) in 3 divided doses for 20 days
- Not to exceed 1.95 g daily
Indications by Disease
Special Populations
- Limited data on use during pregnancy
Renal Dosing
- No adjustments noted by manufacturer
Hepatic Dosing
- No adjustments noted by manufacturer
Contraindications
- Allergy to class/drug, hypersensitivity to iodine and/or 8-hydroxyquinolones
- Concerns with optic neuritis
- Concerns with peripheral neuropathy
- Hepatic impairment
- Renal impairment
- Chronic diarrhea, especially in children
Adverse Reactions
Serious
- Peripheral neuropathy, Long-term (high-dose)
- Optic atrophy, Long-term (high-dose)
- Optic neuritis, Long-term (high-dose)
Common
- Nausea/vomiting, diarrhea, cramps
- Fever/chills
- Pruritus, urticaria
- Headache, dizziness
Pharmacology
- Half-life:
- Metabolism: Liver
- Excretion: Feces, urine
Mechanism of Action
- Contact amebicide that works in the lumen of the intestine (unknown mechanism)
Comments
See Also
References
<UpToDate>
- ↑ Gonzalez ML, et al. Antiamoebic drugs for treating amoebic colitis. Cochrane Database Syst Rev. 2019;1:CD006085. PMID 30624763