Diferencia entre revisiones de «Oxytocin»
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==General== | ==General== | ||
*Type: | *Type: [[Uterotonic]] | ||
*Dosage Forms: | *Dosage Forms: | ||
*Routes of Administration: | *Routes of Administration: IM/IV | ||
*Common Trade Names: Pitocin | *Common Trade Names: Pitocin | ||
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==Special Populations== | ==Special Populations== | ||
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: | *[[Drug Ratings in Pregnancy|Pregnancy Rating]]: X | ||
*[[Lactation risk categories|Lactation risk]]: | *[[Lactation risk categories|Lactation risk]]: Safe | ||
*Renal Dosing | *Renal Dosing | ||
**Adult | **Adult | ||
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==Contraindications== | ==Contraindications== | ||
*Allergy to class/drug | *Allergy to class/drug | ||
*Many contraindications when used to ''induce'' labor | |||
==Adverse Reactions== | ==Adverse Reactions== | ||
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==Pharmacology== | ==Pharmacology== | ||
*Half-life: | *Half-life: 1-6min | ||
*Metabolism: | *Metabolism: | ||
*Excretion: | *Excretion: Urine (small amounts) | ||
*Mechanism of Action: | *Mechanism of Action: "Uterine stimulant, vasopressive, & antidiuretic effects; activates G-protein-coupled receptors that trigger increases in intracellular calcium levels in uterine myofibrils, which results in uterine contractions; increases local prostaglandin production, which further stimulates uterine contraction"<ref>https://reference.medscape.com/drug/pitocin-oxytocin-343132#10</ref> | ||
==Comments== | ==Comments== | ||
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==References== | ==References== | ||
<references/> | <references/> | ||
[[Category: | [[Category:Pharmacology]] | ||
[[Category:OBGYN]] | |||
Revisión actual - 23:16 23 sep 2019
General
- Type: Uterotonic
- Dosage Forms:
- Routes of Administration: IM/IV
- Common Trade Names: Pitocin
Adult Dosing
Postpartum hemorrhage
- 10 international units (IU) can be injected intramuscularly OR[1]
- 20 IU in 1 L of saline may be infused at a rate of 250 mL per hour
- 500 mL can be infused over 10 minutes without complications.
Pediatric Dosing
Special Populations
- Pregnancy Rating: X
- Lactation risk: Safe
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Indications
- First line therapy for postpartum hemorrhage
Contraindications
- Allergy to class/drug
- Many contraindications when used to induce labor
Adverse Reactions
- Rapid administration may cause hypotension
Pharmacology
- Half-life: 1-6min
- Metabolism:
- Excretion: Urine (small amounts)
- Mechanism of Action: "Uterine stimulant, vasopressive, & antidiuretic effects; activates G-protein-coupled receptors that trigger increases in intracellular calcium levels in uterine myofibrils, which results in uterine contractions; increases local prostaglandin production, which further stimulates uterine contraction"[2]
Comments
See Also
References
- ↑ Soriano D et al. A prospective cohort study of oxytocin plus ergometrine compared with oxytocin alone for prevention of postpartum haemorrhage. Br J Obstet Gynaecol. 1996;103:1068–73.
- ↑ https://reference.medscape.com/drug/pitocin-oxytocin-343132#10