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* '''Normal A-a gradient''' ≈ (Age/4) + 4 on room air
* '''Normal A-a gradient''' ≈ (Age/4) + 4 on room air
* '''Elevated A-a gradient''' suggests: V/Q mismatch, shunt, or diffusion impairment
* '''Elevated A-a gradient''' suggests: [[Pulmonary embolism|V/Q mismatch]], [[Respiratory failure|shunt]], or diffusion impairment
* '''Normal A-a gradient + hypoxia''' suggests: hypoventilation or low FiO₂
* '''Normal A-a gradient + hypoxia''' suggests: hypoventilation or low FiO₂
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Revisión actual - 16:50 21 mar 2026

Interactive A-a O₂ Gradient calculator. Requires the calculator gadget. Usage: {{Aa Gradient Calculator}}

A-a O₂ Gradient

Alveolar-arterial (A-a) O₂ Gradient
Parameter Value
Age (years)
FiO₂ (%)
PaCO₂ (mmHg)
PaO₂ (mmHg)
A-a Gradient mmHg
Expected A-a mmHg (age-adjusted normal)
Interpretation
  • Normal A-a gradient ≈ (Age/4) + 4 on room air
  • Elevated A-a gradient suggests: V/Q mismatch, shunt, or diffusion impairment
  • Normal A-a gradient + hypoxia suggests: hypoventilation or low FiO₂
References
  • Formula: A-a = [FiO₂ × (Patm – PH2O)] – (PaCO₂/0.8) – PaO₂
  • Kanber GJ, et al. The alveolar-arterial oxygen gradient in young and elderly men during air and oxygen breathing. Am Rev Respir Dis. 1968;97(3):376-381. PMID 5637791.