Diferencia entre revisiones de «Dopamine»
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Revisión actual - 21:55 20 mar 2026
General
- Type: Vasopressors
- Dosage Forms: IV
- Common Trade Names: Intropin
Indications
- Hypotension caused by:
- Septic shock
- Bradycardia
- MI
- Trauma/spinal shock
- Heart failure
Adult Dosing
- Shock (adjunct):
- 1-50 mcg/kg/min IV
- Max 20-50 mcg/kg/min
- Increase 1-4 mcg/kg/min q10-30 min, titrate to effect
- 1-50 mcg/kg/min IV
- Refractory Heart Failure:
- 1-3 mcg/kg/min IV
- Bradycardia (in patients unresponsive to atropine):
- 2-10 mcg/kg/min IV
- Post-resuscitation stabilization:
- 5-10 mcg/kg/min IV
Pediatric Dosing
- Shock (adjunct):
- 5-10 mcg/kg/min IV (max dose of 20 mcg/kg/min)
- Increase 1-4 mcg/kg/min q10-30 min, titrate to effect
- 5-10 mcg/kg/min IV (max dose of 20 mcg/kg/min)
- Post-resuscitation stabilization:
- 2-20 mcg/kg/min IV/IO
Special Populations
- Pregnancy Rating: Class C
- Lactation: Use caution (limited data)
- Renal Dosing
- Adult: no adjustment
- Pediatric: no adjustment
- Hepatic Dosing
- Adult: N/A
- Pediatric: N/A
Contraindications
- Allergy to class/drug
- Tachyarrhythmias
- Pheochromocytoma
Adverse Reactions
Serious
- Anaphylaxis
- Hypotension
- Ventricular arrhythmias
- Bronchospasm
- Atrial fibrillation
- Extravasation necrosis
- Gangrene
Common
- Tachycardia
- Headache
- Nausea/vomiting
- Anxiety
- Hypertension
- Angina
- Palpitations
- Dyspnea
- Azotemia
Pharmacology[1]
- Half-life:
- 2 minutes
- Metabolism:
- Renal, Hepatic, Plasma
- Excretion:
- Urine as metabolites
- Mechanism of Action:
Primary Receptor
- Low dose: DA, β1
- High dose: DA, α1 >> β1
Relative Effects
- Low dose: Natriuresis, ↑↑HR, ↑↑SV
- High dose: ↑SVR and ↑SV
Indications by Condition
The following table is automatically generated from disease/condition pages across WikEM.
| Indication | Dose | Context | Route | Population |
|---|---|---|---|---|
| Coarctation of the aorta | 5-10mcg/kg/min IV | Inotropic support for CHF | IV | Pediatric |
| Vasopressors | 2-5 mcg/kg/min, max 20 mcg/kg/min | Vasopressor | IV drip | Adult |
| Vasopressors | 2-20mcg/kg/min | Vasopressor/inotrope; dose-dependent receptor effects | IV | Adult |
See Also
References
- ↑ Dopamine: Drug information. UpToDate. www.uptodate.com. Accessed April 2, 2019.