Diferencia entre revisiones de «Diazepam»
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Revisión actual - 21:56 20 mar 2026
General
- Type: Benzodiazepines
- Dosage Forms:
- Common Trade Names: Valium
Adult Dosing
- Anxiety
- PO: 2 - 10 mg 2-4 times daily
- Muscle spasm
- PO: 2 - 10 mg 2-4 times daily
- Sedation in ICU
- IV: Loading dose: 5 - 10 mg, Maintenance dose: 0.03 - 0.1 mg/kg every 30 minutes to 6 hours
Pediatric Dosing
Special Populations
- Pregnancy Rating: D
- Lactation: Diazepam and metabolites are present in breast milk
- Renal Dosing
- Adult
- Not defined
- Pediatric
- Not defined
- Adult
- Hepatic Dosing
- Adult
- Not defined, use with caution, do not used oral tablets in severe hepatic impairment
- Pediatric
- Not defined, use with caution, do not used oral tablets in severe hepatic impairment
- Adult
Contraindications
- Allergy to class/drug
- severe hepatic impairment
Adverse Reactions
Serious
- Respiratory/CNS depression
- Hypotension
- paradoxical CNS stimulation
Common
- drowsiness
- disinhibition
- ataxia
Pharmacology
- Half-life: 30-60 hours
- Metabolism: Liver
- Excretion: Urine
- Mechanism of Action: GABA agonist
Indications by Condition
The following table is automatically generated from disease/condition pages across WikEM.
| Indication | Dose | Context | Route | Population |
|---|---|---|---|---|
| Carbamate poisoning | 5-10mg IV | Seizure control | IV | Adult |
| Carbamate poisoning | 0.2-0.5mg/kg IV | Seizure control | IV | Pediatric |
| Cocaine toxicity | 5-10mg IV q5min PRN agitation | First-line for agitation, seizures, and sympathetic excess | IV | Adult |
| Delirium tremens | 10mg x2, then 20mg x3, then 40mg x3 q5-10min (max 200mg) | First-line escalating dose protocol for DTs | IV | Adult |
| Ethanol withdrawal | 5-10 mg IV q5-10min, increase by 10 mg increments until desired effect | 1st line benzodiazepine (long-acting) | IV | Adult |
| Organophosphate toxicity | 5-10 mg | Seizure control | IV | Adult |
| Organophosphate toxicity | 0.2-0.5 mg/kg | Seizure control | IV | Pediatric |
| Vertigo | 2.5-10 mg q6hr PRN | Benzodiazepine (vestibular suppressant) | PO | Adult |
See Also
References
- Diazepam: Drug information. UpToDate. www.uptodate.com. Accessed April 2, 2019.