Diferencia entre revisiones de «Hepatic encephalopathy»
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==Background== | ==Background== | ||
*Diagnosis of exclusion | *Diagnosis of exclusion | ||
*Due to accumulation of nitrogenous waste products normally metabolized by the liver | *Due to accumulation of nitrogenous waste products normally metabolized by the liver | ||
*Increased metabolism of ammonia to glutamine in CNS | *Increased metabolism of ammonia to glutamine in CNS | ||
*Spectrum of illness ranges from chronic fatigue to acute lethargy | *Spectrum of illness ranges from chronic fatigue to acute lethargy | ||
===Precipitants=== | ===Precipitants=== | ||
*Increased ammonia production, absorption or entry into brain: | *Increased ammonia production, absorption or entry into brain: | ||
**[[GI Bleed]] | **[[Special:MyLanguage/GI Bleed|GI Bleed]] | ||
**Excess dietary intake of protein | **Excess dietary intake of protein | ||
**[[Infection]] (e.g. [[SBP]]) | **[[Special:MyLanguage/Infection|Infection]] (e.g. [[Special:MyLanguage/SBP|SBP]]) | ||
**[[Hypokalemia]] | **[[Special:MyLanguage/Hypokalemia|Hypokalemia]] | ||
**[[Metabolic Alkalosis]] | **[[Special:MyLanguage/Metabolic Alkalosis|Metabolic Alkalosis]] | ||
**[[Constipation]] | **[[Special:MyLanguage/Constipation|Constipation]] | ||
*[[Dehydration]] | *[[Special:MyLanguage/Dehydration|Dehydration]] | ||
**[[Vomiting]] | **[[Special:MyLanguage/Vomiting|Vomiting]] | ||
**[[Diuretics]] | **[[Special:MyLanguage/Diuretics|Diuretics]] | ||
*Drugs | *Drugs | ||
**[[Opioids]] | **[[Special:MyLanguage/Opioids|Opioids]] | ||
**[[Benzodiazepines]] (including [[benzodiazepine withdrawal|withdrawal]]) | **[[Special:MyLanguage/Benzodiazepines|Benzodiazepines]] (including [[Special:MyLanguage/benzodiazepine withdrawal|withdrawal]]) | ||
**[[ETOH]] (including withdrawal) | **[[Special:MyLanguage/ETOH|ETOH]] (including withdrawal) | ||
==Clinical Features== | ==Clinical Features== | ||
[[File:Jaundice08.jpg|thumb|Jaundice of the skin]] | |||
[[File:SpiderAngioma.jpg|thumb|Spider angioma]] | |||
[[File:Hepaticfailure.jpg|thumb||Ascites secondary to [[Special:MyLanguage/cirrhosis|cirrhosis]].]] | |||
===Stages=== | ===Stages=== | ||
*Stage I - General apathy | *Stage I - General apathy | ||
*Stage II - Lethargy, drowsiness, variable orientation, asterixis | *Stage II - Lethargy, drowsiness, variable orientation, asterixis | ||
*Stage III - Stupor with hyperreflexia, marked disorientation, inability to follow commands, extensor plantar reflexes | *Stage III - Stupor with hyperreflexia, marked disorientation, inability to follow commands, extensor plantar reflexes | ||
*Stage IV - Coma | *Stage IV - Coma | ||
==Differential Diagnosis== | ==Differential Diagnosis== | ||
*[[Subdural Hematoma]] | |||
*[[Hypoglycemia]] | *[[Special:MyLanguage/Subdural Hematoma|Subdural Hematoma]] | ||
*[[Wernicke-Korsakoff Syndrome]] | *[[Special:MyLanguage/Hypoglycemia|Hypoglycemia]] | ||
*[[hypernatremia|Hyper]]/[[hyponatremia]] | *[[Special:MyLanguage/Wernicke-Korsakoff Syndrome|Wernicke-Korsakoff Syndrome]] | ||
*[[Benzodiazepine Overdose]] (decreased hepatic clearance) | *[[Special:MyLanguage/hypernatremia|Hyper]]/[[Special:MyLanguage/hyponatremia|hyponatremia]] | ||
*[[Renal Failure]] | *[[Special:MyLanguage/Benzodiazepine Overdose|Benzodiazepine Overdose]] (decreased hepatic clearance) | ||
*[[Sepsis]] | *[[Special:MyLanguage/Renal Failure|Renal Failure]] | ||
*[[Special:MyLanguage/Sepsis|Sepsis]] | |||
==Evaluation== | ==Evaluation== | ||
===Workup=== | ===Workup=== | ||
*CBC | *CBC | ||
*Chemistry | *Chemistry | ||
*Ammonia level | *Ammonia level | ||
*[[LFTs]] | *[[Special:MyLanguage/LFTs|LFTs]] | ||
*PT/PTT | *PT/PTT | ||
*[[Urinalysis]] | *[[Special:MyLanguage/Urinalysis|Urinalysis]] | ||
*[[CXR]] | *[[Special:MyLanguage/CXR|CXR]] | ||
*[[Head CT]] | *[[Special:MyLanguage/Head CT|Head CT]] | ||
*[[Paracentesis]] in patient with ascites (rule out [[SBP]]) | *[[Special:MyLanguage/Paracentesis|Paracentesis]] in patient with ascites (rule out [[Special:MyLanguage/SBP|SBP]]) | ||
*Consider [[LP]] | *Consider [[Special:MyLanguage/LP|LP]] | ||
===Evaluation=== | ===Evaluation=== | ||
*[[Elevated ammonia]] level | |||
*Full neuro exam including asterixis | |||
*[[Special:MyLanguage/Elevated ammonia|Elevated ammonia]] level. Ammonia is not predictive of severity of disease. | |||
*History of any new medications or toxin ingestion | *History of any new medications or toxin ingestion | ||
*Focus exam on looking for signs of [[GI bleed]] or [[hypovolemia]] | *Focus exam on looking for signs of [[Special:MyLanguage/GI bleed|GI bleed]] or [[Special:MyLanguage/hypovolemia|hypovolemia]] | ||
==Management== | ==Management== | ||
*[[Lactulose]] 20g PO or (300mL in 700cc H2O retention enema x30min) | |||
*[[Special:MyLanguage/Lactulose|Lactulose]] 20g PO or (300mL in 700cc H2O retention enema x30min) | |||
**In colon degrades into lactic acid: acidic environment traps ammonia | **In colon degrades into lactic acid: acidic environment traps ammonia | ||
**Also inhibits ammonia production in gut wall | **Also inhibits ammonia production in gut wall | ||
| Línea 62: | Línea 86: | ||
*Rifaximin is second line. | *Rifaximin is second line. | ||
*Some new evidence suggest use of PEG in patients who are not candidates for Lactulose. | *Some new evidence suggest use of PEG in patients who are not candidates for Lactulose. | ||
==Disposition== | ==Disposition== | ||
*Discharge stage I if good resources. | *Discharge stage I if good resources. | ||
*Stage II will need admission unless known encephalopathy and who is otherwise well. | *Stage II will need admission unless known encephalopathy and who is otherwise well. | ||
*Stage III and IV admission +/- ICU or obs bed. | *Stage III and IV admission +/- ICU or obs bed. | ||
==Patient Information== | ==Patient Information== | ||
[http://www.nlm.nih.gov/medlineplus/ency/article/000302.htm Hepatic Encephalopathy] (Medline Plus) | [http://www.nlm.nih.gov/medlineplus/ency/article/000302.htm Hepatic Encephalopathy] (Medline Plus) | ||
==See Also== | ==See Also== | ||
*[[Acute hepatic failure]] | |||
*[[Special:MyLanguage/Acute hepatic failure|Acute hepatic failure]] | |||
==References== | ==References== | ||
<references/> | <references/> | ||
[[Category:GI]] | [[Category:GI]] | ||
</translate> | |||
Revisión actual - 22:59 4 ene 2026
Background
- Diagnosis of exclusion
- Due to accumulation of nitrogenous waste products normally metabolized by the liver
- Increased metabolism of ammonia to glutamine in CNS
- Spectrum of illness ranges from chronic fatigue to acute lethargy
Precipitants
- Increased ammonia production, absorption or entry into brain:
- GI Bleed
- Excess dietary intake of protein
- Infection (e.g. SBP)
- Hypokalemia
- Metabolic Alkalosis
- Constipation
- Dehydration
- Drugs
- Opioids
- Benzodiazepines (including withdrawal)
- ETOH (including withdrawal)
Clinical Features
Ascites secondary to cirrhosis.
Stages
- Stage I - General apathy
- Stage II - Lethargy, drowsiness, variable orientation, asterixis
- Stage III - Stupor with hyperreflexia, marked disorientation, inability to follow commands, extensor plantar reflexes
- Stage IV - Coma
Differential Diagnosis
- Subdural Hematoma
- Hypoglycemia
- Wernicke-Korsakoff Syndrome
- Hyper/hyponatremia
- Benzodiazepine Overdose (decreased hepatic clearance)
- Renal Failure
- Sepsis
Evaluation
Workup
- CBC
- Chemistry
- Ammonia level
- LFTs
- PT/PTT
- Urinalysis
- CXR
- Head CT
- Paracentesis in patient with ascites (rule out SBP)
- Consider LP
Evaluation
- Full neuro exam including asterixis
- Elevated ammonia level. Ammonia is not predictive of severity of disease.
- History of any new medications or toxin ingestion
- Focus exam on looking for signs of GI bleed or hypovolemia
Management
- Lactulose 20g PO or (300mL in 700cc H2O retention enema x30min)
- In colon degrades into lactic acid: acidic environment traps ammonia
- Also inhibits ammonia production in gut wall
- Rifaximin is second line.
- Some new evidence suggest use of PEG in patients who are not candidates for Lactulose.
Disposition
- Discharge stage I if good resources.
- Stage II will need admission unless known encephalopathy and who is otherwise well.
- Stage III and IV admission +/- ICU or obs bed.
Patient Information
Hepatic Encephalopathy (Medline Plus)
See Also