Diferencia entre revisiones de «IV nitroglycerine alternatives»
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*Suggestions for substitution during the IV shortage | *Suggestions for substitution during the IV shortage | ||
===Nitroglycerine Bioavailability=== | ===[[Nitroglycerine]] Bioavailability=== | ||
*Oral <ref>http://sepia.unil.ch/pharmacology/index.php?id=51</ref>: <1% | *Oral <ref name="availability">http://sepia.unil.ch/pharmacology/index.php?id=51</ref>: <1% | ||
*Sublingual <ref | *Sublingual <ref name="availability"/>: 38% (15-40%) | ||
*Topical <ref | *Topical <ref name="availability" />: 72% | ||
Half-life<http://sepia.unil.ch/pharmacology/index.php?id=60> | Half-life<ref>http://sepia.unil.ch/pharmacology/index.php?id=60</ref>: 0.05 h | ||
==Suggested Substitutions<ref>http://www.medpagetoday.com/EmergencyMedicine/EmergencyMedicine/45056</ref>== | ==Suggested Substitutions<ref>http://www.medpagetoday.com/EmergencyMedicine/EmergencyMedicine/45056</ref>== | ||
*Sublingual nitroglycerin, 1-2 tabs or sprays every 5 minutes as needed | |||
**Once controlled | |||
***[[Nitroprusside]] '''OR''' [[Isordil]] PO (nitro paste or longer acting NTG) | |||
**If not well controlled | |||
***IV [[enalapril]] 0.625-1.25mg IV bolus | |||
***IV [[hydralazine]] 5-10mg IV bolus | |||
***IV [[nitroprusside]] | |||
== | ==See Also== | ||
*[[Hypertensive emergency]] | |||
*[[Congestive heart failure]] | |||
==References== | |||
<references> | <references> | ||
[[Category:Pharmacology]] | |||
[[Category:Cardiology]] | |||
Revisión actual - 20:51 22 sep 2019
Background
- Suggestions for substitution during the IV shortage
Nitroglycerine Bioavailability
Half-life[2]: 0.05 h
Suggested Substitutions[3]
- Sublingual nitroglycerin, 1-2 tabs or sprays every 5 minutes as needed
- Once controlled
- Nitroprusside OR Isordil PO (nitro paste or longer acting NTG)
- If not well controlled
- IV enalapril 0.625-1.25mg IV bolus
- IV hydralazine 5-10mg IV bolus
- IV nitroprusside
- Once controlled
See Also
References
<references>