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| ==Background==
| | #REDIRECT[[Isoniazid toxicity]] |
| *Causes low Pyridoxine B6 stores
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| *B6 used to make gaba- an inhibitory neurotransmitter
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| *Also inhibits lactate to pyruvate conversion
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| ==Treatment==
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| *Adults - 1 g of pyridoxine for each gram of INH ingested, to a maximum of 5 g
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| *Children - 1gm/kg regardless of age <ref>Minns, A. et al. Isoniazid-Induced Status Epilepticus in a Pediatric Patient After Inadequate Pyridoxine Therapy. Pediatric Emergency Care. 2010:26(5)380-381</ref>
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| Rate - slow IV infusion at approximately 0.5 g/min until the seizures stop or the maximum dose is reached. Remainder of dose infused over 4 to 6 hours.
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| ==Source==
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| 6/06 MISTRY & Goldfrank's Toxicologic Emergencies
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| [[Category:Tox]] | |
