Diferencia entre revisiones de «Chloroform toxicity»
Sin resumen de edición |
(Text replacement - "==Treatment==" to "==Management==") |
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| (No se muestran 3 ediciones intermedias de 3 usuarios) | |||
| Línea 10: | Línea 10: | ||
==Clinical Presentation== | ==Clinical Presentation== | ||
*Nausea | *[[Nausea]] | ||
*Vomiting | *[[Vomiting]] | ||
*Headache | *[[Headache]] | ||
*Confusion | *[[Confusion]] | ||
*Cardiac arrhythmia | *Cardiac [[arrhythmia]] | ||
*Coma | *Coma | ||
*Renal/Hepatic impairment | *Renal/Hepatic impairment | ||
| Línea 20: | Línea 20: | ||
==Differential Diagnosis== | ==Differential Diagnosis== | ||
== | ==Evaluation== | ||
*Based on clinical presentation | *Based on clinical presentation | ||
*Specific levels rarely available | *Specific levels rarely available | ||
== | ==Management== | ||
*Decontamination | *Decontamination | ||
*Avoid sympathomimetics like epinephrine which may trigger arrhythmia | *Avoid sympathomimetics like epinephrine which may trigger arrhythmia | ||
| Línea 37: | Línea 37: | ||
==References== | ==References== | ||
*Olson, K. Poisoning and Drug Overdose, 1999. | *Olson, K. Poisoning and Drug Overdose, 1999. | ||
[[Category:Toxicology]] | |||
Revisión actual - 21:38 7 dic 2017
Background
- Chloroform (Trichloromethane) is a chlorinated hydrocarbon
- Solvent used in chemical and pharmaceutical industries
Mechanism of Toxicity
- CNS depressant
- Hepatic and renal toxicity via free radical formation
- Arrhythmogenesis
- Carcinogenesis
Clinical Presentation
- Nausea
- Vomiting
- Headache
- Confusion
- Cardiac arrhythmia
- Coma
- Renal/Hepatic impairment
Differential Diagnosis
Evaluation
- Based on clinical presentation
- Specific levels rarely available
Management
- Decontamination
- Avoid sympathomimetics like epinephrine which may trigger arrhythmia
- N-acetylcysteine may minimize renal and hepatic toxicity
Disposition
See Also
External Links
References
- Olson, K. Poisoning and Drug Overdose, 1999.