Diferencia entre revisiones de «Methimazole»
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==Administration== | ==Administration== | ||
*Type: Antithyroid | *Type: Antithyroid | ||
*Dosage Forms: | *Dosage Forms: Tablet; 5mg, 10mg | ||
*Routes of Administration: Oral | *Routes of Administration: Oral | ||
*Common Trade Names: Tapazole | *Common Trade Names: Tapazole | ||
==Adult Dosing== | ==Adult Dosing== | ||
*Thyroid storm: 60 to 80 mg PO daily | *[[Thyroid storm]]: 60 to 80 mg PO daily | ||
*Amiodorone-induced thyrotoxicosis: 40mg PO daily until patient is euthyroid (usually 3-6mo) | *Amiodorone-induced thyrotoxicosis: 40mg PO daily until patient is euthyroid (usually 3-6mo) | ||
*Iodine-induced thyrotoxicosis: 20-40mg PO once | *Iodine-induced thyrotoxicosis: 20-40mg PO once | ||
*Hyperthyroidism | *[[Hyperthyroidism]] | ||
**Initial: 10-20mg/day (mild), 30-40mg/day (moderate), 60mg/day (severe) in 1-3 doses | **Initial: 10-20mg/day (mild), 30-40mg/day (moderate), 60mg/day (severe) in 1-3 doses | ||
**Maintenance: 5-15mg/day | **Maintenance: 5-15mg/day | ||
**2nd-3rd trimester pregnancy: Use lowest dose needed to keep maternal total T3/T4 | **2nd-3rd trimester pregnancy: Use lowest dose needed to keep maternal total T3/T4 slightly above normal range for pregnancy, TSH suppressed, and free T4 at or slightly above upper limit of normal for nonpregnant women | ||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
*Hyperthyroidism: | *Hyperthyroidism: | ||
**Initial: 0.2-0.5 mg/kg PO daily OR 0.4mg/kg PO daily in 3 divided doses | **Initial: 0.2-0.5 mg/kg PO daily '''OR''' 0.4mg/kg PO daily in 3 divided doses | ||
**Maintenance: 50% of initial dose | **Maintenance: 50% of initial dose | ||
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==Comments== | ==Comments== | ||
==Indications by Condition== | |||
''The following table is automatically generated from disease/condition pages across WikEM.'' | |||
{{#ask:[[Has DrugName::Methimazole]] | |||
|?Has Indication=Indication | |||
|?Has Dose=Dose | |||
|?Has Context=Context | |||
|?Has Route=Route | |||
|?Has Population=Population | |||
|format=table | |||
|headers=plain | |||
|mainlabel=- | |||
|sort=Has Indication | |||
|limit=50 | |||
}} | |||
==See Also== | ==See Also== | ||
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<references/> | <references/> | ||
[[Category:Pharmacology]] | [[Category:Pharmacology]] | ||
[[Category:Endocrinology]] | |||
Revisión actual - 21:58 20 mar 2026
Administration
- Type: Antithyroid
- Dosage Forms: Tablet; 5mg, 10mg
- Routes of Administration: Oral
- Common Trade Names: Tapazole
Adult Dosing
- Thyroid storm: 60 to 80 mg PO daily
- Amiodorone-induced thyrotoxicosis: 40mg PO daily until patient is euthyroid (usually 3-6mo)
- Iodine-induced thyrotoxicosis: 20-40mg PO once
- Hyperthyroidism
- Initial: 10-20mg/day (mild), 30-40mg/day (moderate), 60mg/day (severe) in 1-3 doses
- Maintenance: 5-15mg/day
- 2nd-3rd trimester pregnancy: Use lowest dose needed to keep maternal total T3/T4 slightly above normal range for pregnancy, TSH suppressed, and free T4 at or slightly above upper limit of normal for nonpregnant women
Pediatric Dosing
- Hyperthyroidism:
- Initial: 0.2-0.5 mg/kg PO daily OR 0.4mg/kg PO daily in 3 divided doses
- Maintenance: 50% of initial dose
Special Populations
- Pregnancy Rating: D - see pregnancy dosing
- Lactation risk: Infant risk cannot be ruled out
- Renal dosing: no adjustment
- Hepatic dosing: no adjustment
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- Agranulocytosis, aplastic anemia
- Vasculitis
- Pancreatitis
- Hepatotoxicity
Common
- Rash
Pharmacology
- Half-life: 2-28h
- Metabolism: Hepatic
- Excretion: Renal
Mechanism of Action
- Inhibits thyroperoxidase, thus blocking synthesis of thyroid hormones
Comments
Indications by Condition
The following table is automatically generated from disease/condition pages across WikEM.
| Indication | Dose | Context | Route | Population |
|---|---|---|---|---|
| Thyroid storm | 20-25 mg PO q6h (can give PR at same dose) | Thionamide (alternative to PTU) | PO/PR | Adult |