Diferencia entre revisiones de «Trazodone»
(Created page with "==Administration== *Type: Antidepressant *Dosage Forms: *Routes of Administration: oral *Common Trade Names: ==Adult Dosing== *Insomnia: 50-100mg PO at bedtime *Depression:...") |
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*Dosage Forms: | *Dosage Forms: | ||
*Routes of Administration: oral | *Routes of Administration: oral | ||
*Common Trade Names: | *Common Trade Names: Desyrel | ||
==Adult Dosing== | ==Adult Dosing== | ||
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==Mechanism of Action== | ==Mechanism of Action== | ||
*Not well understood. May act like a SSRI. Also an | *Not well understood. May act like a SSRI. Also an α-1 adrenergic antagonist | ||
==Comments== | ==Comments== | ||
==See Also== | ==See Also== | ||
*[[Trazodone toxicity]] | |||
==References== | ==References== | ||
<references/> | <references/> | ||
[[Category:Pharmacology]] | [[Category:Pharmacology]] | ||
[[Category:Psychiatry]] | |||
Revisión actual - 06:40 1 dic 2021
Administration
- Type: Antidepressant
- Dosage Forms:
- Routes of Administration: oral
- Common Trade Names: Desyrel
Adult Dosing
- Insomnia: 50-100mg PO at bedtime
- Depression: 150-600 mg/day in divided doses
Pediatric Dosing
Safety/efficacy not established
Special Populations
- Pregnancy Rating: C
- Lactation risk: Infant risk cannot be ruled out
- Renal dosing: no adjustment
- Hepatic dosing: no adjustment
Contraindications
- Allergy to class/drug
- MAOI use currently or in past 2 weeks
- Concomitant use of saquinavir/ritonavir
Adverse Reactions
Serious
- Prolonged QT, Torsades de pointes
- Hypotension
- Serotonin syndrome
- Suicidal thoughts/behavior
- Seizure
- Priapism
Common
- Somnolence, dizziness, confusion, insomnia, anxiety, dream disorder
- Headache, blurred vision
- Constipation, nausea/vomiting, xerostomia
- Backache
Pharmacology
- Half-life: 7h
- Metabolism: Hepatic, CYP3A4
- Excretion: Mostly renal
Mechanism of Action
- Not well understood. May act like a SSRI. Also an α-1 adrenergic antagonist