Sepsis antibiotics

Unknown Source

	Harbor-UCLA	Santa Monica-UCLA
Community Acquired	Ceftriaxone 1 g IV + Vancomycin 1 g IV + Gentamicin 5mg/kg + Metronidazole 500mg g IV	Piperacillin/tazobactam 4.5g IV q6h OR cefepime 1g IV q8h OR meropenem 1g IV q8h +/- vancomycin 15mg/kg/dose IV q12h (Max dose = 1500mg) +/- gentamicin 7mg/kg/dose IV q24h +/- fluconazole 400mg IV q24h
Health Care Associated (or allergy)	Option 1: Cefepime 2 g IV + Vancomycin 1 g IV + Gentamicin 5-7 mg/kg + Metronidazole 500mg g IV Option 2: Meropenem 2 g IV + Vancomycin 1 g IV	aztreonam 2g IV q8h OR levofloxacin 750mg IV q24h +/- vancomycin 15mg/kg/dose IV q12h (Max dose = 1500mg) +/- gentamicin 7mg/kg/dose IV q24h +/- fluconazole 400mg IV q24h

Intra-Abdominal

Intra-Abdominal Sepsis/Peritonitis

	Harbor-UCLA	Santa Monica-UCLA	Other
Primary	Metronidazole 500mg IV q8hrs Plus one of the following: Ceftriaxone 1g IV once daily Ciprofloxacin 400mg IV q12hrs Cefazolin 1g (30mg/kg) IV q8hrs Levofloxacin 750mg IV once daily	Metronidazole 500mg IV q8h + Vancomycin 15mg/kg/dose IV q12h (Max dose = 1500mg) Plus one of the following: Piperacillin/tazobactam 4.5g IV q6h Ertapenem 1g IV q24h Ceftriaxone 1g IV q24h	One of the following: Piperacillin-tazobactam Ticarcillin-clavulanate 3.1 g IV every 6 hours Ertapenem 1 g every 24 hours Moxifloxacin 400 mg IV every 24 hours
Allergy or prior exposure	Piperacillin/Tazobactam 4.5g (80mg/kg) IV q8hrs OR Metronidazole 500mg IV q8hrs PLUS Cefepime 2g IV once daily OR Ciprofloxacin 400mg IV q12hrs OR Levofloxacin 750mg IV once daily Meropenem 1g (20mg/kg) IV q8hrs OR Doripenem 500mg IV q8hrs OR Aztreonam 2g (30mg/kg) IV q8hrs + Metronidazole 500mg IV q8hrs	aztreonam 2g IV q8h + metronidazole 500mg IV q8h +/- vancomycin 15mg/kg/dose IV q12h (Max dose = 1500mg)

Pediatric

• Metronidazole 7.5mg/kg IV q8hrs (max 500mg) + one of:
  • Ceftriaxone 50-75mg/kg IV daily (max 2g) OR
  • Cefotaxime 50mg/kg IV q8hrs (max 2g/dose)
• Piperacillin/Tazobactam 80-100mg/kg IV q6-8hrs (max 4.5g) OR
• Meropenem 20mg/kg IV q8hrs (max 1g)

See Also

Antibiotics by diagnosis

• Bone and joint antibiotics
• Cardiovascular antibiotics
• ENT antibiotics
• Eye antibiotics
• GI antibiotics
• GU antibiotics
• Neuro antibiotics
• OB/GYN antibiotics
• Pulmonary antibiotics
• Skin and soft tissue antibiotics
• Bioterrorism antibiotics
• Environmental exposure antibiotics
• Immunocompromised antibiotics
• Post exposure prophylaxis antibiotics
• Pediatric antibiotics
• Sepsis antibiotics
• Arthropod and parasitic antibiotics

For antibiotics by organism see Microbiology (Main)

• See Initial Antibiotics in Sepsis (Main)

• UCLA
  • Initial Antibiotics in Sepsis - Harbor
  • Initial Antibiotics in Sepsis - Santa Monica
• Initial Antibiotics in Sepsis - Uncited