Diferencia entre revisiones de «Dapsone»
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| Línea 7: | Línea 7: | ||
*Hansen dz (leprosy) | *Hansen dz (leprosy) | ||
**paucibacillary: 100 mg PO qd x6mo | **paucibacillary: 100 mg PO qd x6mo | ||
**Use w/ rifampin | ***Use w/ rifampin | ||
**multibacillary: 100 mg PO qd x12mo | **multibacillary: 100 mg PO qd x12mo | ||
**Use w/ rifampin, clofazimine | ***Use w/ rifampin, clofazimine | ||
*Dermatitis herpetiformis: 50 mg PO qd | *Dermatitis herpetiformis: 50 mg PO qd | ||
| Línea 18: | Línea 18: | ||
*PCP tx: 100 mg PO qd x21 days | *PCP tx: 100 mg PO qd x21 days | ||
**Not 1st-line agent; use w/ trimethoprim | **Not 1st-line agent; use w/ trimethoprim | ||
**Off label use | |||
*Malaria suppression: 100 mg PO qwk | *Malaria suppression: 100 mg PO qwk | ||
**Use w/ pyrimethamine | **Use w/ pyrimethamine | ||
**Off label use | |||
*Toxoplasmosis prophylaxis: 50 mg PO qd | *Toxoplasmosis prophylaxis: 50 mg PO qd | ||
**Off label use | |||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
Revisión del 12:56 20 ene 2016
Administration
- Type: Antibiotic
- Dosage Forms: 25,100
- Routes of Administration: Oral
Adult Dosing
- Hansen dz (leprosy)
- paucibacillary: 100 mg PO qd x6mo
- Use w/ rifampin
- multibacillary: 100 mg PO qd x12mo
- Use w/ rifampin, clofazimine
- paucibacillary: 100 mg PO qd x6mo
- Dermatitis herpetiformis: 50 mg PO qd
- PCP prophylaxis: 100 mg/day PO divided qd-bid
- Off label use
- PCP tx: 100 mg PO qd x21 days
- Not 1st-line agent; use w/ trimethoprim
- Off label use
- Malaria suppression: 100 mg PO qwk
- Use w/ pyrimethamine
- Off label use
- Toxoplasmosis prophylaxis: 50 mg PO qd
- Off label use
Pediatric Dosing
Special Populations
Renal Dosing
- No adjustment
Hepatic Dosing
- Caution advised with hepatic impairment
Contraindications
- Allergy to class/drug
- caution if renal or hepatic impairment
- caution if impaired cardiovascular fxn
Adverse Reactions
Serious
- anemia, hemolytic
- aplastic anemia
- agranulocytosis
- exfoliative dermatitis
- erythema multiforme
- toxic epidermal necrolysis
Common
- fever
- myalgia
- headache
- rigors
- fatigue
- malaise
- dizziness
Pharmacology
- Half-life: 28 hrs
- Metabolism: Liver, CYP450
- Excretion: Urine
Mechanism of Action
Comments
See Also
References
<Epocrates, UpToDate>