Diferencia entre revisiones de «Kawasaki disease»
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| Línea 45: | Línea 45: | ||
*Red Top "Kawasaki Serum to CBR" | *Red Top "Kawasaki Serum to CBR" | ||
==Evaluation== | ===Evaluation=== | ||
*Clinical diagnosis | *Clinical diagnosis | ||
{| class="wikitable" | {| class="wikitable" | ||
| align="center" style="background:#f0f0f0;"|'''Classic Kawasaki Disease''' | | align="center" style="background:#f0f0f0;"|'''Classic Kawasaki Disease''' | ||
| align="left" style="background:#f0f0f0;"|Fever for 5 days or more '''plus''' four of the following symptoms | | align="left" style="background:#f0f0f0;"|Fever for 5 days or more '''plus''' four of the following symptoms | ||
|- | |- | ||
| ||1. Bilateral nonexudative conjunctivitis | | ||1. Bilateral nonexudative [[conjunctivitis]] | ||
|- | |- | ||
| ||2. Mucous membrane changes (erythema, peeling, cracking of lips, "strawberry tongue," or diffuse oropharyngeal mucosae) | | ||2. Mucous membrane changes (erythema, peeling, cracking of lips, "strawberry tongue," or diffuse oropharyngeal mucosae) | ||
| Línea 59: | Línea 58: | ||
| ||3. Changes of the extremities (erythema or swelling of hands/feet, peeling of finger tips/toes in the convalescent stage) | | ||3. Changes of the extremities (erythema or swelling of hands/feet, peeling of finger tips/toes in the convalescent stage) | ||
|- | |- | ||
| ||4. Rash | | ||4. [[Rash]] | ||
|- | |- | ||
| ||5. Cervical adenopathy (more than one node >1.5 cm unusually unilateral anterior cervical) | | ||5. Cervical adenopathy (more than one node >1.5 cm unusually unilateral anterior cervical) | ||
| Línea 69: | Línea 68: | ||
| ||1. Albumin <3 grams/dL | | ||1. Albumin <3 grams/dL | ||
|- | |- | ||
| ||2. Anemia | | ||2. [[Anemia]] | ||
|- | |- | ||
| ||3. Elevated alanine aminotransferase (ALT) | | ||3. Elevated alanine aminotransferase (ALT) | ||
Revisión del 07:53 12 nov 2015
Background
- Also known as: mucocutaneous lymph node syndrome
- Vasculitis of unknown etiology
- Peaks at 18-24 months
- Rare in <4mo, >5yr
- Leading cause of acquired heart disease in children
- Coronary aneurysm more common in incomplete than in classic KD
Clinical Features
- Fever that is high, abrupt
- Rash often seen in perineum; accompanies onset of fever
- Maculopapular most common; vesicles not seen
- Cardiac complications develop early on
- Coronary artery aneurysm development most prevalent as fever lessens
Associated Symptoms
- Cardiac
- Coronary aneurysm
- Most develop during 3-4th week of illness
- May lead to MI (leading cause of death)
- Myo/pericarditis
- Pericardial effusion
- LV dysnfunction
- Valvular dysfunction
- Dysrhythmias
- Coronary aneurysm
- Labs
- Elevated ESR/WBC/LFTs/Plts
- Aseptic meningitis
- Urethritis
- Anemia
- RUQ pain, large GB (hydrops)
Differential Diagnosis
Pediatric fever
- Upper respiratory infection (URI)
- UTI
- Sepsis
- Meningitis
- Febrile seizure
- Juvenile rheumatoid arthritis
- Pneumonia
- Acute otitis media
- Whooping cough
- Unclear source
- Kawasaki disease
- Neonatal HSV
- Specific virus
Diagnosis
Work-Up
- CBC
- LFTs
- ESR, CRP
- Blood culture
- UA
- ECG
- TTE (Coronaries, LV, valves)
- Red Top "Kawasaki Serum to CBR"
Evaluation
- Clinical diagnosis
| Classic Kawasaki Disease | Fever for 5 days or more plus four of the following symptoms |
| 1. Bilateral nonexudative conjunctivitis | |
| 2. Mucous membrane changes (erythema, peeling, cracking of lips, "strawberry tongue," or diffuse oropharyngeal mucosae) | |
| 3. Changes of the extremities (erythema or swelling of hands/feet, peeling of finger tips/toes in the convalescent stage) | |
| 4. Rash | |
| 5. Cervical adenopathy (more than one node >1.5 cm unusually unilateral anterior cervical) | |
| Incomplete Kawasaki Disease | Fever for 5 days and two to three clinical criteria of classic Kawasaki disease plus |
| C-reactive protein 3.0 milligrams/L and/or erythrocyte sedimentation rate 40 mm/h plus positive echocardiogram or three or more of the following: | |
| 1. Albumin <3 grams/dL | |
| 2. Anemia | |
| 3. Elevated alanine aminotransferase (ALT) | |
| 4. Platelets >450,000/mm3 7d after fever onset | |
| 5. White blood cell count >12,000/mm3 | |
| 6. Pyuria |
Management
- IVIG 2gm/kg over 12hr
- Aspirin 20mg/kg/dose q6h
Disposition
- Admit