Diferencia entre revisiones de «Microangiopathic hemolytic anemia»

Revisión del 13:06 29 jun 2015

A variety of conditions that result in damaged endothelium of small vessels causing platelet aggregation and fibrin deposition which leads to shearing forces within these small vessels causing an intravascular fragmentation hemolysis

Clinical features + heme labs with red blood cell fragments or schistocytes.^[1]
May have bleeding and thrombosis

Most common causes: DIC, TTP, HUS
Other medical causes: malignant hypertension, HELLP, Antiphospholipid Syndrome (APS), scleroderma, Paroxysmal Nocturnal Hemoglobinuria (PNH), malignancy, renal allograft rejection, vasculitides like polyarteritis nodosa and Wegener's granulomatosis
Drugs: chemotherapy; Clopidogrel (Plavix) associated with TTP
Nonvascular causes: prosthetic valve (more common w/ mechanical, more common at aortic valve), LVAD, TIPS, coil embolization, patched AV shunt, AVM

Peripheral smear, hemoglobin, platelets, PT/INR, PTT, fibrinogen, FDPs, D-dimer, haptoglobin, LDH, bilirubin
- Schistocytes (aka Helmet cells) secondary to fragmentation hemolysis classic finding on peripheral smear

↑ ^1.0 ^1.1 ^1.2 Scully. Marie et al. Guidelines on the diagnosis and management of thrombotic thrombocytopenic purpura and other thrombotic microangiopathies. Br J Haematol. 2012 Aug;158(3):323-35. PDF

Authors:

@@ Línea 1: / Línea 1: @@
 ==Background==
-'''Microangiopathic hemolytic anemia (MAHA)''' = variety of conditions that result in damaged endothelium of small vessels causing platelet aggregation and fibrin deposition which leads to shearing forces within these small vessels causing an intravascular fragmentation hemolysis
+*A variety of conditions that result in damaged endothelium of small vessels causing platelet aggregation and fibrin deposition which leads to shearing forces within these small vessels causing an intravascular fragmentation hemolysis
 ==Clinical Features==