Diferencia entre revisiones de «Babesiosis»
| Línea 24: | Línea 24: | ||
===Option 1=== | ===Option 1=== | ||
*Atovaquone (750mg BID) and [[Azithromycin]] (500-1000mg on first day, 250-1000mg on subsequent days) | *Atovaquone (750mg BID) and [[Azithromycin]] (500-1000mg on first day, 250-1000mg on subsequent days)<ref>Krause PJ, Lepore T, Sikand VK, Gadbaw J Jr, Burke G, Telford SR 3rd, et al. Atovaquone and azithromycin for the treatment of babesiosis. N Engl J Med. Nov 16 2000;343(20):1454-8.</ref> | ||
===Option 2=== | ===Option 2=== | ||
| Línea 32: | Línea 32: | ||
===Pediatrics=== | ===Pediatrics=== | ||
*Clindamycin 20 mg/kg/day for children and 25 mg/kg/day for children for 7-10 days | *Clindamycin 20 mg/kg/day for children and 25 mg/kg/day for children for 7-10 days | ||
==See Also== | ==See Also== | ||
Revisión del 15:05 4 jun 2015
Background
- Spread by the deer tick (Ixodes scapularis)
- People often unaware they are bitten
- Natural reservior is the white footed mouse
- Endemic in US, Europe, parts of Russia and China
- Babesia Microti is pathogen in US
Symptoms
- Fever, hemolytic anemia, chills, thrombocytopenia, DIC
- More severe disease in immunocompromized patients (HIV, Elderly, Asplenic)
Diagnosis
- Peripheral blood smear
- Shows intracellular parasites
- Maltese Cross sign
- May need large smear as parasitemia can be as low as 1%
- Can often be confused for malaria parasites
- Shows intracellular parasites
Differential Diagnosis
Tick Borne Illnesses
- Babesiosis
- Colorado tick fever
- Ehrlichiosis
- Heartland virus
- Lyme
- Murine typhus
- Rocky mountain spotted fever
- Southern tick-associated rash illness (STARI)
- Tick paralysis
- Tularemia
Management
- 2 drug regimen for 7-10 days
Option 1
- Atovaquone (750mg BID) and Azithromycin (500-1000mg on first day, 250-1000mg on subsequent days)[1]
Option 2
- Clindamycin 600mg PO q8hrs x 7-10 days (or 300-600mg IV q6hrs)
- Give with Quinine 650mg TID
Pediatrics
- Clindamycin 20 mg/kg/day for children and 25 mg/kg/day for children for 7-10 days
See Also
Sources
- ↑ Krause PJ, Lepore T, Sikand VK, Gadbaw J Jr, Burke G, Telford SR 3rd, et al. Atovaquone and azithromycin for the treatment of babesiosis. N Engl J Med. Nov 16 2000;343(20):1454-8.