Diferencia entre revisiones de «Fluconazole»

Revisión actual - 09:10 22 mar 2026

General

Type: Antifungal
Dosage Forms: IV; PO
Common Trade Names: Diflucan

Adult Dosing

General

Candidiasis, oropharyngeal/esophageal

100mg PO qday x 2 week to prevent relapse

Candida vaginitis

Uncomplicated: 150mg PO x 1

Indications by Disease

Disease	Dose	Context
Acute necrotizing ulcerative gingivitis	200mg PO daily x 14 days	Immunocompromised
Candida vulvovaginitis	150mg PO once	Preferred; a second dose at 72hrs may be given if still symptomatic
Candida vulvovaginitis	150mg PO q72h x 3 doses	Severe or immunosuppressed
Candida vulvovaginitis	150mg PO qweek x 6 months	Recurrent; long-term suppressive therapy
Cryptococcosis	400mg PO/IV q24hrs x 6-12 months	Pulmonary not AIDS associated
Cryptococcosis	400mg PO q24hrs x 6-12 months	Pulmonary with AIDS
Cryptococcosis	400mg PO q24hrs x 8 weeks	Meningitis consolidation not AIDS
Cryptococcosis	400mg PO q24hrs x 8 weeks	Meningitis consolidation with AIDS
Oropharyngeal candidiasis	200 mg PO on day one, followed by 100 mg daily for two weeks	Adult

Pediatric Dosing

Candidiasis, oropharyngeal/esophageal:

> 14 days old: 6mg/kg PO x 1, then 3mg/kg q24h x 7-14 days, max: 100mg/day

Tinea Capitis: > 14 days old: 3-6mg/kg PO q24h x 6 weeks

Indications by Disease

Disease	Dose	Context
Cryptococcosis	6-12mg/kg PO daily x 8 weeks (max 400mg)	Pediatric Consolidation
Oropharyngeal candidiasis	6 mg/kg PO on day one, followed by 3 mg/kg daily for two weeks	Pediatric
Tinea capitis	6mg/kg PO daily (max 400mg) x 3-6 weeks	Second line

Special Populations

Pregnancy Rating: D
Lactation Risk Categories: safety unknown
Renal Dosing
- Adult:CrCrl < 50, give usual loading dose x 1 then decrease dose 50%
- Pediatric: CrCrl < 50, give usual loading dose x 1 then decrease dose 50%
Hepatic Dosing
- Adult: not defined
- Pediatric: not defined

Contraindications

Allergy to class/drug

Adverse Reactions

Serious

hepatotoxicity
seizures
leukopenia
thrombocytopenia
anaphylaxis
steven-johnson syndrome
QT prolongation

Common

Nausea
Rash
Headache
vomiting
diarrhea
Transaminitis

Pharmacology

Half-life: 30 hour
Metabolism: Liver
Excretion: urine
Mechanism of Action: inhibits cytochrome P450 and sterol c-14 alpha-demethylation

References

Authors:

@@ Línea 1: / Línea 1: @@
 ==General==
-*Type: Antifungal
+*Type: [[Antifungal]]
 *Dosage Forms: IV; PO
 *Common Trade Names: Diflucan
@@ Línea 6: / Línea 6: @@
 ==Adult Dosing==
 ===General===
-Candidiasis, oropharyngeal/esophageal
+[[Candidiasis]], oropharyngeal/esophageal
-* 100 mg PO qday x 2 week to prevent relapse
+*100mg PO qday x 2 week to prevent relapse
-Candidiasis,vulvovaginal
+[[Candida vaginitis]]
-*Uncomplicated: 150 mg PO x 1
+*Uncomplicated: 150mg PO x 1
+===Indications by Disease===
+{{#ask: [[Has DrugName::Fluconazole]] [[Has Population::Adult]]
+ |?Treats disease=Disease
+ |?Has Dose=Dose
+ |?Has Context=Context
+ |format=table
+ |limit=50
+ |mainlabel=-
+ |headers=show
+ |sort=Treats disease
+}}
 ==Pediatric Dosing==
 Candidiasis, oropharyngeal/esophageal:
-* > 14 days old: 6 mg/kg PO x 1, then 3 mg/kg q24h x 7-14 days, max: 100 mg/day
+*> 14 days old: 6mg/kg PO x 1, then 3mg/kg q24h x 7-14 days, max: 100mg/day
 Tinea Capitis:
-> 14 days old: 3-6 mg/kg PO q24h x 6 weeks
+> 14 days old: 3-6mg/kg PO q24h x 6 weeks
+===Indications by Disease===
+{{#ask: [[Has DrugName::Fluconazole]] [[Has Population::Pediatric]]
+ |?Treats disease=Disease
+ |?Has Dose=Dose
+ |?Has Context=Context
+ |format=table
+ |limit=50
+ |mainlabel=-
+ |headers=show
+ |sort=Treats disease
+}}
 ==Special Populations==
@@ Línea 55: / Línea 81: @@
 *Metabolism: Liver
 *Excretion: urine
-*Mechanism of Action: inhibits cytochrome p450 and sterol c-14 alpha-demethylation
+*Mechanism of Action: inhibits cytochrome [[P450]] and sterol c-14 alpha-demethylation
+==See Also==
+*[[Antifungals]]
+*[[Fungal infections]]
+==External Links]]
+==References==
+<references/>
+[[Category:Pharmacology]]
+[[Category:ID]]