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(Expand: common causes, slit-lamp evaluation, ophthalmology consult before treatment)
 
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==Background==
==Background==
 
*Collection of white blood cells (leukocytic exudate) layering in the anterior chamber of the eye
*A sign of severe intraocular inflammation — not a diagnosis itself
*Always indicates significant pathology requiring urgent evaluation
*'''Most common causes in EM:''' [[corneal ulcer]] (infectious keratitis), severe [[uveitis]], [[endophthalmitis]]


==Clinical Features==
==Clinical Features==
*A leukocytic exudate, seen in the anterior chamber
*White or yellow-white layering fluid visible at the dependent (inferior) portion of the anterior chamber
*A sign of inflammation of the anterior uvea and iris
*Best visualized on [[slit-lamp]] exam
*The exudate settles at the dependent aspect of the eye due to gravity
*Associated findings depend on etiology:
**[[Eye pain]], photophobia, tearing
**[[Red eye]], ciliary flush
**Decreased visual acuity


==Differential Diagnosis==
==Differential Diagnosis==
*[[Corneal ulcer]]
*[[Corneal ulcer]] (infectious keratitis) — most common cause; look for corneal infiltrate/opacity
*Behcet's disease
*[[Endophthalmitis]] — post-surgical or post-traumatic; vitreous involvement
*[[Endophthalmitis]]
*[[Uveitis]] (anterior) — may be idiopathic or associated with systemic disease
*[[Traumatic iritis]] (severe)
*[[Behcet's disease]] — recurrent hypopyon with oral/genital ulcers
*Intraocular tumor (rare)


==Evaluation==
==Evaluation==
 
*Visual acuity
*[[Slit-lamp]] exam: quantify hypopyon height (mm), assess cornea for ulcer/infiltrate, anterior chamber cells/flare
*Fluorescein staining: rule out [[corneal ulcer]]
*IOP measurement (may be elevated or low)
*Dilated fundoscopic exam if endophthalmitis suspected (vitreous haze)
*'''If corneal ulcer:''' Obtain corneal scrapings for culture before starting antibiotics (ophthalmology)


==Management==
==Management==
 
*'''Emergent ophthalmology consult''' for all cases
*Do not start treatment until ophthalmology evaluates (may need cultures first)
*Treatment depends on underlying cause:
**Infectious keratitis: Fortified topical antibiotics (ophthalmology-directed)
**Uveitis: Topical steroids + cycloplegic (ophthalmology-directed)
**Endophthalmitis: Intravitreal antibiotics ± vitrectomy


==Disposition==
==Disposition==
*Emergent optho consult
*Emergent ophthalmology consult from ED
*Most cases require close daily ophthalmology follow-up or admission


==See Also==
==See Also==
[[Hyphema]]
*[[Hyphema]]
 
*[[Corneal ulcer]]
 
*[[Uveitis]]
 
*[[Endophthalmitis]]
==External Links==
 


==References==
==References==
<references/>
<references/>
[[Category:Ophthalmology]]
[[Category:Ophthalmology]]

Revisión actual - 01:45 21 mar 2026

Background

  • Collection of white blood cells (leukocytic exudate) layering in the anterior chamber of the eye
  • A sign of severe intraocular inflammation — not a diagnosis itself
  • Always indicates significant pathology requiring urgent evaluation
  • Most common causes in EM: corneal ulcer (infectious keratitis), severe uveitis, endophthalmitis

Clinical Features

  • White or yellow-white layering fluid visible at the dependent (inferior) portion of the anterior chamber
  • Best visualized on slit-lamp exam
  • Associated findings depend on etiology:
    • Eye pain, photophobia, tearing
    • Red eye, ciliary flush
    • Decreased visual acuity

Differential Diagnosis

  • Corneal ulcer (infectious keratitis) — most common cause; look for corneal infiltrate/opacity
  • Endophthalmitis — post-surgical or post-traumatic; vitreous involvement
  • Uveitis (anterior) — may be idiopathic or associated with systemic disease
  • Traumatic iritis (severe)
  • Behcet's disease — recurrent hypopyon with oral/genital ulcers
  • Intraocular tumor (rare)

Evaluation

  • Visual acuity
  • Slit-lamp exam: quantify hypopyon height (mm), assess cornea for ulcer/infiltrate, anterior chamber cells/flare
  • Fluorescein staining: rule out corneal ulcer
  • IOP measurement (may be elevated or low)
  • Dilated fundoscopic exam if endophthalmitis suspected (vitreous haze)
  • If corneal ulcer: Obtain corneal scrapings for culture before starting antibiotics (ophthalmology)

Management

  • Emergent ophthalmology consult for all cases
  • Do not start treatment until ophthalmology evaluates (may need cultures first)
  • Treatment depends on underlying cause:
    • Infectious keratitis: Fortified topical antibiotics (ophthalmology-directed)
    • Uveitis: Topical steroids + cycloplegic (ophthalmology-directed)
    • Endophthalmitis: Intravitreal antibiotics ± vitrectomy

Disposition

  • Emergent ophthalmology consult from ED
  • Most cases require close daily ophthalmology follow-up or admission

See Also

References