Diferencia entre revisiones de «Rasburicase»
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==Administration== | ==Administration== | ||
*Type: Enzyme | *Type: Enzyme | ||
*Dosage Forms: | *Dosage Forms: Solution; 1.5mg & 7.5mg | ||
*Routes of Administration: IV | *Routes of Administration: IV | ||
*Common Trade Names: Elitek | *Common Trade Names: Elitek | ||
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*Fever (severe), rigors | *Fever (severe), rigors | ||
===Common=== | ===Common=== | ||
*Peripheral Edema | |||
*Fever | *Fever | ||
*Rash | *Rash | ||
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==Comments== | ==Comments== | ||
==Indications by Condition== | |||
''The following table is automatically generated from disease/condition pages across WikEM.'' | |||
{{#ask:[[Has DrugName::Rasburicase]] | |||
|?Has Indication=Indication | |||
|?Has Dose=Dose | |||
|?Has Context=Context | |||
|?Has Route=Route | |||
|?Has Population=Population | |||
|format=table | |||
|headers=plain | |||
|mainlabel=- | |||
|sort=Has Indication | |||
|limit=50 | |||
}} | |||
==See Also== | ==See Also== | ||
Revisión actual - 21:58 20 mar 2026
Administration
- Type: Enzyme
- Dosage Forms: Solution; 1.5mg & 7.5mg
- Routes of Administration: IV
- Common Trade Names: Elitek
Adult Dosing
- Hyperuricemia due to tumor lysis syndrome: 0.2 mg/kg IV over 30 minutes daily for up to 5 days
Pediatric Dosing
- 0.2 mg/kg IV over 30 minutes daily for up to 5 days
Special Populations
- Pregnancy Rating: C
- Lactation risk: Infant risk cannot be ruled out
- Renal dosing:
- Hepatic dosing:
Contraindications
- Allergy to class/drug
- G6PD deficiency
- History of hemolytic reaction to rasburicase or any excipients
- History of methemoglobinemia reaction to rasburicase or any excipients
Adverse Reactions
Serious
- Dysrhythmia, MI, heart failure, cardiac arrest
- Bowel obstruction
- Severe diarrhea, dehydration
- Methemoglobinemia
- Neutropenia, hemolysis, thrombocytopenia, pancytopenia
- Hemorrhage, thrombosis
- Sepsis
- Stroke
- Renal failure
- Pulmonary edema, pulmonary hypertension, pneumonia, respiratory distress
- Fever (severe), rigors
Common
- Peripheral Edema
- Fever
- Rash
- Diarrhea, nausea/vomiting, constipation, abdominal pain
- Mucous membrane inflammation
- Headache
Pharmacology
- Half-life: 18h
- Metabolism: liver
- Excretion:
Mechanism of Action
- Enzyme catalyzes oxidation of uric acid into inactive and soluble metabolite
Comments
Indications by Condition
The following table is automatically generated from disease/condition pages across WikEM.
| Indication | Dose | Context | Route | Population |
|---|---|---|---|---|
| Tumor lysis syndrome | 0.05-0.2 mg/kg | Urate oxidase (prevention and treatment) | IV | Adult |