Diferencia entre revisiones de «Succimer»
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==Comments== | ==Comments== | ||
==Indications by Condition== | |||
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==See Also== | ==See Also== | ||
Revisión actual - 21:57 20 mar 2026
Administration
- Type: Antidote
- Dosage Forms: Capsule 100mg
- Routes of Administration: Oral
- Common Trade Names: Chemet
Adult Dosing
Lead poisoning
- 10 to 30 mg/kg/day for 5 days
Pediatric Dosing
Safety/efficacy not established in patients <12mo
- Lead poisoning, level >45 mcg/dL: 10 mg/kg or 350 mg/m(2) q8h for 5 days, then q12 h for 14 days
Special Populations
- Pregnancy Rating: C
- Lactation risk: Avoid breastfeeding during treatment and for at least 5 days after d/c. Possible risk of infant toxicity
- Renal dosing: administer with caution, ensure adequate hydration
- Hepatic dosing: no adjustment, monitor LFTs closely
Contraindications
- Allergy to class/drug
- Breastfeeding during treatment and five days after d/c
- ANC < 1200
Adverse Reactions
Serious
Common
Pharmacology
- Half-life: 48h
- Metabolism: Site unknown
- Excretion: Renal 25%, feces 39%, lungs 1%
Mechanism of Action
- Forms stable, water-soluble complexes with lead, leading to increased urinary excretion
Comments
Indications by Condition
The following table is automatically generated from disease/condition pages across WikEM.
| Indication | Dose | Context | Route | Population |
|---|---|---|---|---|
| Lead toxicity | 10mg/kg PO TID x 5 days, then 10mg/kg PO BID x 14 days | Oral chelation, pediatric first-line | PO | Pediatric |
| Mercury toxicity | 10mg/kg PO TID x 5 days, then 10mg/kg BID x 14 days | Oral chelation | PO | Adult |
