Diferencia entre revisiones de «Gemifloxacin»
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==General== | ==General== | ||
*Type: [[ | *Type: [[Is Generation:: 4th generation]] [[Is DrugClass::Fluoroquinolones]] | ||
*Dosage Forms: Oral (320mg) | *Dosage Forms: Oral (320mg) | ||
*Common Trade Names: Factive | *Common Trade Names: Factive | ||
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===Gonoccocal infection=== | ===Gonoccocal infection=== | ||
*320mg PO x1 with [[azithromycin]] | *320mg PO x1 with [[azithromycin]] | ||
===Indications by Disease=== | |||
{{#ask: [[Has DrugName::Gemifloxacin]] [[Has Population::Adult]] | |||
|?Treats disease=Disease | |||
|?Has Dose=Dose | |||
|?Has Context=Context | |||
|format=table | |||
|limit=50 | |||
|mainlabel=- | |||
|headers=show | |||
|sort=Treats disease | |||
}} | |||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
*No current dosing | *No current dosing | ||
===Indications by Disease=== | |||
{{#ask: [[Has DrugName::Gemifloxacin]] [[Has Population::Pediatric]] | |||
|?Treats disease=Disease | |||
|?Has Dose=Dose | |||
|?Has Context=Context | |||
|format=table | |||
|limit=50 | |||
|mainlabel=- | |||
|headers=show | |||
|sort=Treats disease | |||
}} | |||
==Special Populations== | ==Special Populations== | ||
Revisión actual - 20:38 20 mar 2026
General
- Type: 4th generation Fluoroquinolones
- Dosage Forms: Oral (320mg)
- Common Trade Names: Factive
Adult Dosing
Pneumonia, community-acquired
- 320 mg PO q24h for at least 5 days
Chronic bronchitis, acute bacterial exacerbation
- 320 mg PO q24h x5 days
Gonoccocal infection
- 320mg PO x1 with azithromycin
Indications by Disease
| Disease | Dose | Context |
|---|---|---|
| Pneumonia (main) | 320 mg daily | Outpatient, Unhealthy |
Pediatric Dosing
- No current dosing
Indications by Disease
Special Populations
- Pregnancy Rating: C; potential for fetotoxicity at higher doses
- Lactation: L3; no human data available.
- Renal Dosing
- Adult
- CrCl <40: 160mg q24h
- HD/PD: No supplement
- Pediatric
- N/A
- Adult
- Hepatic Dosing
- Adult
- No adjustment
- Pediatric
- N/A
- Adult
Contraindications
- Allergy to class/drug
- Myasthenia gravis
- QT prolongation
- Uncorrected electrolyte abnormaliteis
Adverse Reactions
Serious
- Anaphylaxis, hypersensitivity reaction
- C. Diff associated diarrhea
- Seizures
- Toxic psychosis, depression, suicidality
- Hyperglycemia
- Phototoxicity
- Vasulitis
- Serum sickness
- Hepatotoxicity, Nephrotoxicity
- Myelosuppression, Blood dyscrasias
- QT Prolongation, Torsades de pointes
- Peripheral neuropathy
- Tendon rupture
- Arthropathy
- Myasthenia gravis exacerbation
Common
- Diarrhea, nausea, Vomiting
- Headache, dizziness
- Rash
- Tendinitis
- Arthralgia, Myalgia
- Insomnia, anxiety, confusion
Pharmacology
- Half-life: 7h
- Metabolism: Liver minimally
- Excretion: Feces 61%, Urine 36%
- Mechanism of Action: Inhibits DNA gyrase and topoisomerase IV
Antibiotic Sensitivities[1]
Key
- S susceptible/sensitive (usually)
- I intermediate (variably susceptible/resistant)
- R resistant (or not effective clinically)
- S+ synergistic with cell wall antibiotics
- U sensitive for UTI only (non systemic infection)
- X1 no data
- X2 active in vitro, but not used clinically
- X3 active in vitro, but not clinically effective for Group A strep pharyngitis or infections due to E. faecalis
- X4 active in vitro, but not clinically effective for strep pneumonia
See Also
References
- ↑ Sanford Guide to Antimicrobial Therapy 2014