Diferencia entre revisiones de «Cephalexin»
(Text replacement - "Category:Drugs" to "Category:Pharmacology") |
(Remove disease-specific entries now covered by AntibioticDose (3 sections)) |
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==General== | ==General== | ||
*Type: 1st generation [[cephalosporin]] | *Type: [[Is Generation::1st generation]] [[Is DrugClass::cephalosporin]] | ||
*Dosage forms | *Dosage forms | ||
**Tabs: 250mg, 500mg, 750mg | **Tabs: 250mg, 500mg, 750mg | ||
**Liquid: 125mg/5mL; 250mg/5mL | **Liquid: 125mg/5mL; 250mg/5mL | ||
*Common Trade Names: Keflex | *Common Trade Names: Keflex, Keftab, Biocef | ||
==Adult Dosing== | ==Adult Dosing== | ||
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*Max: 4g/day | *Max: 4g/day | ||
===[[ | ===Indications by Disease=== | ||
{{#ask: [[Has DrugName::Cephalexin]] [[Has Population::Adult]] | |||
|?Treats disease=Disease | |||
|?Has Dose=Dose | |||
|?Has Context=Context | |||
|format=table | |||
=== | |limit=50 | ||
|mainlabel=- | |||
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|sort=Treats disease | |||
}} | |||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
===General=== | ===General=== | ||
*25- | *25-50mg/kg/day PO divided q6-12h | ||
*Max: 500mg/dose | *Max: 500mg/dose | ||
===Skin Infections=== | ===Skin Infections=== | ||
*25- | *25-50mg/kg/day PO divided q12h | ||
*Max: 500mg/dose | *Max: 500mg/dose | ||
===Indications by Disease=== | |||
{{#ask: [[Has DrugName::Cephalexin]] [[Has Population::Pediatric]] | |||
|?Treats disease=Disease | |||
|?Has Dose=Dose | |||
|?Has Context=Context | |||
|format=table | |||
|limit=50 | |||
|mainlabel=- | |||
|headers=show | |||
|sort=Treats disease | |||
}} | |||
==Special Populations== | ==Special Populations== | ||
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*[[Cephalosporin Cross-reactivity]] | *[[Cephalosporin Cross-reactivity]] | ||
== | ==References== | ||
<references/> | |||
*Sanford 2010 | *Sanford 2010 | ||
*Epocrates | *Epocrates | ||
*Lexicomp | *Lexicomp | ||
[[Category:Pharmacology]] | [[Category:Pharmacology]] [[Category:ID]] | ||
Revisión actual - 11:08 20 mar 2026
General
- Type: 1st generation cephalosporin
- Dosage forms
- Tabs: 250mg, 500mg, 750mg
- Liquid: 125mg/5mL; 250mg/5mL
- Common Trade Names: Keflex, Keftab, Biocef
Adult Dosing
General
- 250-500mg PO q6h
- Max: 4g/day
Indications by Disease
| Disease | Dose | Context |
|---|---|---|
| Acute cystitis | 250mg QID x 5d | Outpatient, Women Uncomplicated |
| Cellulitis | 500mg PO q6hrs | Outpatient |
| Erysipelas | 500mg (6.25mg/kg) PO q6hrs x 10 days | Alternative |
| Felon | 500mg PO q6hrs daily x 7 days | Outpatient |
| Impetigo | 500mg (6.25mg/kg) PO q6hrs x 10 days | Oral therapy |
| Mastitis | 500mg PO q6hrs | First line alternative |
| Pyelonephritis | 500mg QID PO x 10-14 days (OR consider 1000mg BID) | Outpatient |
| Streptococcal pharyngitis | 20 mg per kg PO BID (maximum 500 mg per dose) x 10 days | Penicillin Allergy (mild) |
| Suppurative parotitis | 500mg (12.5mg/kg) PO four times daily | Outpatient |
Pediatric Dosing
General
- 25-50mg/kg/day PO divided q6-12h
- Max: 500mg/dose
Skin Infections
- 25-50mg/kg/day PO divided q12h
- Max: 500mg/dose
Indications by Disease
| Disease | Dose | Context |
|---|---|---|
| Acute cystitis | 25-50mg/kg/day PO divided q6-8h x 7-10 days (max 500mg/dose) | Pediatric |
| Acute otitis media | 75-100mg/kg/day PO divided q12h x 10 days; Max: 4,000mg/24h | Otitis Media |
| Cellulitis | 25-50mg/kg/day PO divided q6-8h (max 500mg/dose) | Pediatric Outpatient |
| Endocarditis | 50mg/kg PO (max 2g) | Pediatric Dental Prophylaxis, mild PCN Allergy |
| Erysipelas | 25-50mg/kg/day PO divided q6-8h x 10 days (max 500mg/dose) | Pediatric |
| Impetigo | 25-50mg/kg/day PO divided q6-8h x 7-10 days (max 500mg/dose) | Pediatric Oral |
| Pharyngitis | 40mg/kg/day PO divided q12h x 10 days; Max: 500mg/dose | Streptococcal Pharyngitis (>1 Year) |
| Pyelonephritis | 25-50mg/kg/day PO divided q6-8h x 10-14 days (max 500mg/dose) | Pediatric Outpatient |
| Streptococcal pharyngitis | 20mg/kg PO BID x 10 days (max 500mg/dose) | Pediatric PCN Allergy |
| Suppurative parotitis | 50mg/kg/day PO divided QID (max 500mg/dose) | Pediatric Outpatient |
Special Populations
- Pregnancy Rating: B
- Lactation risk categories: Enters breast milk/L3
- Renal
- Adult
- CrCl 50-90: give q6-8h
- CrCl 10-50: give q8-12h
- CrCl <10: give q12-24h
- Hemodialysis: give dose after dialysis, no supplement
- Peritoneal dialysis: no supplement
- Pediatric
- CrCl 30-50: give q8h
- CrCl 10-29: give q12h
- CrCl <10: give q24h
- Hemodialysis: give dose after dialysis, no supplement
- Peritoneal dialysis: no supplement
- Adult
- Hepatic (Adult & Pediatric)
- Not defined
Contraindications
- Allergy to class/drug
- See also Cephalosporin Cross-reactivity
- Caution advised with contraceptives
Adverse Drug Reactions
Serious
- Anaphylaxis
- Angioedema
- Erythema Multiforme
- Stevens-Johnson Syndrome
- Toxic Epidermal Necrolysis
- Clostridium difficile
- Neutropenia
- Thrombocytopenia
- Hemolytic anemia
- Hemorrhage
- Hepatitis
- Cholestatic jaundice
- Seizures
Common
Pharmacology
- Half-life: 1h (~20hr ESRD)
- Metabolism: Minimal
- Excretion: Primarily urine (>90% unchanged)
- Mechanism of Action:
- Bactericidal, inhibits cell wall
Antibiotic Sensitivities[1]
Key
- S susceptible/sensitive (usually)
- I intermediate (variably susceptible/resistant)
- R resistant (or not effective clinically)
- S+ synergistic with cell wall antibiotics
- U sensitive for UTI only (non systemic infection)
- X1 no data
- X2 active in vitro, but not used clinically
- X3 active in vitro, but not clinically effective for Group A strep pharyngitis or infections due to E. faecalis
- X4 active in vitro, but not clinically effective for strep pneumonia
See Also
References
- ↑ Sanford Guide to Antimicrobial Therapy 2014
- Sanford 2010
- Epocrates
- Lexicomp
