Diferencia entre revisiones de «Template:Toxoplasmosis Antibiotics»
(Convert to AntibioticDose with disease=Toxoplasmosis for SMW linking) |
(Add AntibioticDose entries: Dapsone) |
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*[[Pyrimethamine]] (25 mg/day orally) and sulfadiazine (4 g/day orally) divided 2 or 4 times daily until delivery AND | *[[Pyrimethamine]] (25 mg/day orally) and sulfadiazine (4 g/day orally) divided 2 or 4 times daily until delivery AND | ||
**[[Leucovorin]] 10-25 mg/day orally to prevent bone marrow suppression | **[[Leucovorin]] 10-25 mg/day orally to prevent bone marrow suppression | ||
*{{AntibioticDose|drug=Dapsone|dose=50mg PO QD; Off label use|context=Toxoplasmosis prophylaxis|disease=Toxoplasmosis|population=Adult}} | |||
Revisión del 10:54 20 mar 2026
Immunocompetent
Antibiotics only needed if patient has severe symptoms
- Pyrimethamine 200mg PO load then 50mg PO q24hrs x 4 weeks AND
- Leucovorin 10mg PO q24hrs AND
- Sulfadiazine 1g PO q6hrs
Immunosprepressed
- Pyrimethamine 200mg PO load then 75mg PO q24hrs x 4-8 weeks AND Leucovorin 25mg PO q24hrs PLUS
- Sulfadiazine 1500mg PO q6hrs OR
- Clindamycin 600mg PO or IV q6hrs OR
- Azithromycin 1200mg PO q24hrs OR
- Atovaquone 1500mg PO q12hrs
OR
- TMP/SMX 5mg/kg IV q12hrs
Pregnant
- Spiramycin 1g PO q8hrs[1]
- If amniotic fluid is positive treat with 3 weeks of pyrimethamine (50 mg/day orally) + sulfadiazine (3 g/day orally in 2-3 divided doses)
- Alternate with a 3-week course of Spiramycin 1 g 3 times daily OR
- Pyrimethamine (25 mg/day orally) and sulfadiazine (4 g/day orally) divided 2 or 4 times daily until delivery AND
- Leucovorin 10-25 mg/day orally to prevent bone marrow suppression
- Dapsone 50mg PO QD; Off label use
- ↑ Paquet C, Yudin MH. Toxoplasmosis in pregnancy: prevention, screening, and treatment. J Obstet Gynaecol Can. Jan 2013;35(1):78-9.