Diferencia entre revisiones de «Atorvastatin»
| Línea 40: | Línea 40: | ||
==Pharmacology== | ==Pharmacology== | ||
*Half-life: | *Half-life: Approximately 14 hours<ref>McIver LA, Siddique MS. Atorvastatin. [Updated 2022 Nov 13]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK430779/</ref> | ||
*Metabolism: | *Metabolism: Metabolized by cytochrome CYP3A4 | ||
*Excretion: | *Excretion: Metabolites are eliminated via bile. | ||
==Mechanism of Action== | ==Mechanism of Action== | ||
Revisión del 15:54 20 ago 2023
Administration
- Type: Statins (HMG-CoA Reductase Inhibitor)
- Dosage Forms:
- Routes of Administration: PO
- Common Trade Names: Lipitor
Adult Dosing
Hyperlipidemia
- Moderate Intensity: 10-20 mg PO daily
- High Intensity: 40-80 mg PO daily
Acute Coronary Syndrome
- 80 mg PO (Single dose prior to PCI)
Pediatric Dosing
Special Populations
- Pregnancy Rating: X
- Lactation risk: Generally not recommended while breastfeeding
- Renal Dosing
- No adjustment
- Hepatic Dosing
- Contraindicated in patients with active liver disease
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- Hepatotoxicity
- Rhabdomyolysis
Common
- Arthralgias
- Dyspepsia
- Nausea
- UTI
- Insomnia
Pharmacology
- Half-life: Approximately 14 hours[1]
- Metabolism: Metabolized by cytochrome CYP3A4
- Excretion: Metabolites are eliminated via bile.
Mechanism of Action
Comments
See Also
References
- ↑ McIver LA, Siddique MS. Atorvastatin. [Updated 2022 Nov 13]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK430779/