Dilantin Load

First time load

18mg/kg (can be given PO in divided doses or IV)

Already On

If patient is already on dilantin but sub-therapeutic use following to calculate dose needed to achieve therapeutic level:

Concentration adjusted = (concentration desired - concentration measured) x (0.7 x adjusted body weight)

Correcting

1. Sheiner-Tozer Equation may be needed to correct level in patients with low albumin or abnormal creatinine:
   1. Corrected level = measured level/[(adjustment x albumin) + 0.1]
   2. adjustment is 0.2 unless patient has Creatinine clearance <20 then it is 0.1

See Also

Seizure Levels and Reloading