Diferencia entre revisiones de «Selective serotonin reuptake inhibitor toxicity»
(Text replacement - "==Treatment==" to "==Management==") |
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| Línea 11: | Línea 11: | ||
*QRS, [[QT prolongation]] (citalopram only) | *QRS, [[QT prolongation]] (citalopram only) | ||
*[[Serotonin syndrome]] | *[[Serotonin syndrome]] | ||
*Coma and seizures (rare) | |||
==Differential Diagnosis== | ==Differential Diagnosis== | ||
Revisión del 14:18 1 sep 2019
Background
- Most serious adverse effect is potential to produce Serotonin Syndrome
- Fatalities are uncommon with pure overdoses
Clinical Features
- Nausea and vomiting
- Sedation
- Tremor
- Sinus tachycardia
- QRS, QT prolongation (citalopram only)
- Serotonin syndrome
- Coma and seizures (rare)
Differential Diagnosis
Anticholinergic toxicity Causes
- Medications[1]
- Atropine
- Antihistamines
- Antidepressants
- Antipsychotics
- Muscle relaxants
- Anti-Parkinsonians
- Plants
- Jimson weed (Devil's trumpet)
- Amanita mushroom
Management
- GI decontamination
- Activated charcoal x1
- Gastric lavage unnecessary
Disposition
- Consider admission for patients who are tachycardic or lethargic 6hr after ingesion
See Also
References
- ↑ Dawson AH, Buckley NA. Pharmacological management of anticholinergic delirium – theory, evidence and practice. Br J Clin Pharmacol. 2015;81(3):516-24.