Diferencia entre revisiones de «Cytokine release syndrome»
| Línea 7: | Línea 7: | ||
==Differential Diagnosis== | ==Differential Diagnosis== | ||
*distinguish [[tumor lysis syndrome]] | |||
*sepsis | |||
*hemophagocytic lymphohistiocytosis | |||
==Evaluation== | ==Evaluation== | ||
Revisión del 16:35 21 ago 2019
Background
- Cytokine release syndrome form of systemic inflammatory response syndrome from adverse effect of some monoclonal antibody drugs, as well as adoptive T-cell therapies
Clinical Features
- septic shock: hypotension, hypoxia, dyspnea, fever, tachycardia
- organ specific dysfunction: encephalopathy, coagulopathy, renal failure, CHF
Differential Diagnosis
- distinguish tumor lysis syndrome
- sepsis
- hemophagocytic lymphohistiocytosis
Evaluation
- cytopenias, elevated creatinine and liver enzymes, deranged coagulation parameters, high CRP
Management
- treat for sepsis
- consider Tocilizumab (IL-6 receptor antagonist)
- corticosteroids for severe cases
Disposition
- admit