Diferencia entre revisiones de «Respiratory acidosis»

Sin resumen de edición
Sin resumen de edición
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==DDX==
==DDX==
#COPD
#[[COPD]]
#Drugs (opioids)
#Drugs ([[Opioids]])
#Chest wall dz
#Chest wall dz
#Pleural dz
#Pleural dz
Línea 25: Línea 25:
##Bronchodilators
##Bronchodilators
##CPAP
##CPAP
##Intubation (esp of pH < 7.25)
##[[Intubation]] (esp of pH < 7.25)
###Do not reduce pH too quickly (>5Hg/h)
###Do not reduce pH too quickly (>5Hg/h)
####Can lead to abrupt hypocalcemia/hypokalemia
####Can lead to abrupt [[Hypocalcemia]]/[[Hypokalemia]]
 
==See Also==
[[Acid-Base]]


==Source ==
==Source ==

Revisión del 08:15 18 dic 2013

Background

  • acidemia = pH < 7.38
  • respiratory acidosis = pCO2 > 42
  • Acute respiratory acidosis: Change in pH = 0.008 X (40 - PaCO2)

vs. Chronic respiratory acidosis: Change in pH = 0.003 X (40 - PaCO2)

  • determine if another primary acid/base disturbance is occurring
    • calculate AG
    • if HCO3 < 24 + (pCO2-40)/10 x 3(+/-1) then there is a superimposed primary metabolic acidosis
      • for every 10mm increase in pCO2 >40, HCO3expected increases by 2-4mEq (2 if acute/limited time for metabolic compensation, 4 if chronic i.e. COPD)
    • if HCO3 > 24 + (pCO2-40)/10 x 3(+/-1) then suspect primary metabolic alkalosis


Etiology

Hypoventilation - acute vs chronic

DDX

  1. COPD
  2. Drugs (Opioids)
  3. Chest wall dz
  4. Pleural dz
  5. Trauma

Treatment

  1. Improve alveolar ventilation
    1. Bronchodilators
    2. CPAP
    3. Intubation (esp of pH < 7.25)
      1. Do not reduce pH too quickly (>5Hg/h)
        1. Can lead to abrupt Hypocalcemia/Hypokalemia

See Also

Acid-Base

Source

Tintinalli, KAJI 2011