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===[[Serotonin syndrome]] vs [[neuroleptic malignant syndrome]]===
===[[Serotonin syndrome]] vs [[Neuroleptic malignant syndrome]]===
*Differentiation between the [[serotonin syndrome]] and [[NMS]] can be challenging. History of a new serotonergic drug or a dose increase of a serotonergic drug are helpful. [[serotonin syndrome]] is usually much more acute in onset than NMS which may develop over days or weeks. On physical exam the presence of ‘lead pipe’ rigidity is typical of NMS, while patients with [[serotonin syndrome]] manifest tremor and hyperreflexia.
*History of a new serotonergic drug or a dose increase of a serotonergic drug are helpful
*Elevations in creatine kinase, liver function tests (lactate dehydrogenase, aspartate transaminase), and white blood cell count, coupled with a low serum iron level, distinguishes NMS from [[serotonin syndrome]] among patients taking neuroleptic and serotonin agonist medications simultaneously.
*Serotonin syndrome is usually much more acute in onset than NMS which may develop over days or weeks
*Presence of ‘lead pipe’ rigidity is typical of NMS, while serotonin syndrome typically manifests with tremor and hyperreflexia
*Elevations in CK, LFTs, and WBC, coupled with a low iron level, distinguishes NMS from serotonin syndrome among patients taking both neuroleptic and serotonin agonist medications simultaneously

Revisión actual - 04:33 13 feb 2017

Serotonin syndrome vs Neuroleptic malignant syndrome

  • History of a new serotonergic drug or a dose increase of a serotonergic drug are helpful
  • Serotonin syndrome is usually much more acute in onset than NMS which may develop over days or weeks
  • Presence of ‘lead pipe’ rigidity is typical of NMS, while serotonin syndrome typically manifests with tremor and hyperreflexia
  • Elevations in CK, LFTs, and WBC, coupled with a low iron level, distinguishes NMS from serotonin syndrome among patients taking both neuroleptic and serotonin agonist medications simultaneously
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