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	<id>https://wikem.org/w/index.php?action=history&amp;feed=atom&amp;title=Wheal</id>
	<title>Wheal - Revision history</title>
	<link rel="self" type="application/atom+xml" href="https://wikem.org/w/index.php?action=history&amp;feed=atom&amp;title=Wheal"/>
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	<updated>2026-04-17T12:29:38Z</updated>
	<subtitle>Revision history for this page on the wiki</subtitle>
	<generator>MediaWiki 1.38.2</generator>
	<entry>
		<id>https://wikem.org/w/index.php?title=Wheal&amp;diff=375563&amp;oldid=prev</id>
		<title>Rossdonaldson1: /* References */</title>
		<link rel="alternate" type="text/html" href="https://wikem.org/w/index.php?title=Wheal&amp;diff=375563&amp;oldid=prev"/>
		<updated>2025-01-29T18:40:12Z</updated>

		<summary type="html">&lt;p&gt;&lt;span dir=&quot;auto&quot;&gt;&lt;span class=&quot;autocomment&quot;&gt;References&lt;/span&gt;&lt;/span&gt;&lt;/p&gt;
&lt;table style=&quot;background-color: #fff; color: #202122;&quot; data-mw=&quot;interface&quot;&gt;
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				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;← Revisión anterior&lt;/td&gt;
				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;Revisión del 18:40 29 ene 2025&lt;/td&gt;
				&lt;/tr&gt;&lt;tr&gt;&lt;td colspan=&quot;2&quot; class=&quot;diff-lineno&quot; id=&quot;mw-diff-left-l43&quot;&gt;Línea 43:&lt;/td&gt;
&lt;td colspan=&quot;2&quot; class=&quot;diff-lineno&quot;&gt;Línea 43:&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;&amp;lt;references/&amp;gt;&lt;/div&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;&amp;lt;references/&amp;gt;&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;br/&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;br/&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class=&quot;diff-marker&quot; data-marker=&quot;−&quot;&gt;&lt;/td&gt;&lt;td style=&quot;color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;[[Dermatology]]&lt;/div&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot; data-marker=&quot;+&quot;&gt;&lt;/td&gt;&lt;td style=&quot;color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;[[&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;Category:&lt;/ins&gt;Dermatology&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;]]&lt;/ins&gt;&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td colspan=&quot;2&quot; class=&quot;diff-side-deleted&quot;&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot; data-marker=&quot;+&quot;&gt;&lt;/td&gt;&lt;td style=&quot;color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;[[Category:Symptoms&lt;/ins&gt;]]&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;/table&gt;</summary>
		<author><name>Rossdonaldson1</name></author>
	</entry>
	<entry>
		<id>https://wikem.org/w/index.php?title=Wheal&amp;diff=372619&amp;oldid=prev</id>
		<title>Rossdonaldson1: /* References */</title>
		<link rel="alternate" type="text/html" href="https://wikem.org/w/index.php?title=Wheal&amp;diff=372619&amp;oldid=prev"/>
		<updated>2024-02-14T16:06:21Z</updated>

		<summary type="html">&lt;p&gt;&lt;span dir=&quot;auto&quot;&gt;&lt;span class=&quot;autocomment&quot;&gt;References&lt;/span&gt;&lt;/span&gt;&lt;/p&gt;
&lt;table style=&quot;background-color: #fff; color: #202122;&quot; data-mw=&quot;interface&quot;&gt;
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				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;← Revisión anterior&lt;/td&gt;
				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;Revisión del 16:06 14 feb 2024&lt;/td&gt;
				&lt;/tr&gt;&lt;tr&gt;&lt;td colspan=&quot;2&quot; class=&quot;diff-lineno&quot; id=&quot;mw-diff-left-l42&quot;&gt;Línea 42:&lt;/td&gt;
&lt;td colspan=&quot;2&quot; class=&quot;diff-lineno&quot;&gt;Línea 42:&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;==References==&lt;/div&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;==References==&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;&amp;lt;references/&amp;gt;&lt;/div&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;&amp;lt;references/&amp;gt;&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td colspan=&quot;2&quot; class=&quot;diff-side-deleted&quot;&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot; data-marker=&quot;+&quot;&gt;&lt;/td&gt;&lt;td style=&quot;color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;&lt;/ins&gt;&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td colspan=&quot;2&quot; class=&quot;diff-side-deleted&quot;&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot; data-marker=&quot;+&quot;&gt;&lt;/td&gt;&lt;td style=&quot;color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;[[Dermatology]]&lt;/ins&gt;&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;/table&gt;</summary>
		<author><name>Rossdonaldson1</name></author>
	</entry>
	<entry>
		<id>https://wikem.org/w/index.php?title=Wheal&amp;diff=371603&amp;oldid=prev</id>
		<title>Patricklin: Created page with &quot;==Background== *In urticaria (hives), both wheals and angioedema are present. Wheals result from localized edema of upper dermis, while angioedema results from edema of lower dermal and subcutaneous tissues&lt;ref&gt;Bernstein JA, Moellman J. Emerging concepts in the diagnosis and treatment of patients with undifferentiated angioedema. Int J Emerg Med. 2012 Nov 6;5(1):39. doi: 10.1186/1865-1380-5-39. PMID: 23131076; PMCID: PMC3518251. &lt;/ref&gt; *Mast cell and basophil act...&quot;</title>
		<link rel="alternate" type="text/html" href="https://wikem.org/w/index.php?title=Wheal&amp;diff=371603&amp;oldid=prev"/>
		<updated>2023-09-30T17:22:31Z</updated>

		<summary type="html">&lt;p&gt;Created page with &amp;quot;==Background== *In &lt;a href=&quot;/wiki/Urticaria&quot; class=&quot;mw-redirect&quot; title=&quot;Urticaria&quot;&gt;urticaria&lt;/a&gt; (hives), both wheals and &lt;a href=&quot;/wiki/Angioedema&quot; title=&quot;Angioedema&quot;&gt;angioedema&lt;/a&gt; are present. Wheals result from localized edema of upper dermis, while angioedema results from edema of lower dermal and subcutaneous tissues&amp;lt;ref&amp;gt;Bernstein JA, Moellman J. Emerging concepts in the diagnosis and treatment of patients with undifferentiated angioedema. Int J Emerg Med. 2012 Nov 6;5(1):39. doi: 10.1186/1865-1380-5-39. PMID: 23131076; PMCID: PMC3518251. &amp;lt;/ref&amp;gt; *Mast cell and basophil act...&amp;quot;&lt;/p&gt;
&lt;p&gt;&lt;b&gt;Página nueva&lt;/b&gt;&lt;/p&gt;&lt;div&gt;==Background==&lt;br /&gt;
*In [[urticaria]] (hives), both wheals and [[angioedema]] are present. Wheals result from localized edema of upper dermis, while angioedema results from edema of lower dermal and subcutaneous tissues&amp;lt;ref&amp;gt;Bernstein JA, Moellman J. Emerging concepts in the diagnosis and treatment of patients with undifferentiated angioedema. Int J Emerg Med. 2012 Nov 6;5(1):39. doi: 10.1186/1865-1380-5-39. PMID: 23131076; PMCID: PMC3518251. &amp;lt;/ref&amp;gt;&lt;br /&gt;
*Mast cell and basophil activation involving the release of vasoactive substances&lt;br /&gt;
*Broad differential diagnosis of etiologies&lt;br /&gt;
**Sometimes iatrogenic; for example, skin wheals from intradermal lidocaine infiltration, allergy skin prick test, tuberculin skin test&lt;br /&gt;
&lt;br /&gt;
==Clinical Features==&lt;br /&gt;
* Papules that are well-circumscribed but irregular, pruritic, and often with a pale center and red flare on the borders&lt;br /&gt;
* Transient duration, usually hours, with spontaneous self-resolution&lt;br /&gt;
* If related to anaphylaxis or allergy, may also involve other systems such as respiratory, circulatory, GI &lt;br /&gt;
&lt;br /&gt;
[[File:Urticarial wheal.jpg|thumb|Urticarial wheal]]&lt;br /&gt;
&lt;br /&gt;
==Differential Diagnosis==&lt;br /&gt;
*[[Anaphylaxis]]&lt;br /&gt;
*[[Acute allergic reaction]]&lt;br /&gt;
*[[Contrast induced allergic reaction]]&lt;br /&gt;
*[[Acute transfusion reaction]]&lt;br /&gt;
*[[Chronic urticaria]]&lt;br /&gt;
*[[Dermatographism]]&lt;br /&gt;
*[[Cold urticaria]]&lt;br /&gt;
&lt;br /&gt;
==Evaluation==&lt;br /&gt;
*Clinical diagnosis&lt;br /&gt;
**Take a thorough history to assess for precipitating factors, including recent foods, travel, medications/treatments, insect bites/stings, autoimmune disease, viral infections, anaphylaxis history, etc&lt;br /&gt;
**Check for association with overlying objects such as watches, jewelry clothing, bands, etc&lt;br /&gt;
&lt;br /&gt;
==Management==&lt;br /&gt;
* If any suspicion of anaphylaxis, treat with IM [[epinephrine]]&lt;br /&gt;
* 2nd gen H1 [[antihistamines]] are effective; if ineffective, consider  [[corticosteroids]] and H2 antihistamines&amp;lt;ref&amp;gt;Schaefer P. Acute and Chronic Urticaria: Evaluation and Treatment. Am Fam Physician. 2017 Jun 1;95(11):717-724. PMID: 28671445.&amp;lt;/ref&amp;gt;&lt;br /&gt;
* Avoid any causative agent or medications if identified, and treat the underlying illness&lt;br /&gt;
&lt;br /&gt;
==Disposition==&lt;br /&gt;
*Observe in ED for 4-6 hours until symptoms improve; utilize clinical gestalt&lt;br /&gt;
*If anaphylactic picture, after observation discharge with anaphylaxis emergency plan and epipen&lt;br /&gt;
&lt;br /&gt;
==See Also==&lt;br /&gt;
*[[Angioedema]]&lt;br /&gt;
*[[Anaphylaxis]]&lt;br /&gt;
*[[Acute allergic reaction]]&lt;br /&gt;
&lt;br /&gt;
==References==&lt;br /&gt;
&amp;lt;references/&amp;gt;&lt;/div&gt;</summary>
		<author><name>Patricklin</name></author>
	</entry>
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