Vitamin B9 deficiency - Revision history

Elcatracho: /* See Also */

2021-02-23T19:24:47Z

Elcatracho: /* Causes */

2021-02-23T19:24:17Z

Causes

← Revisión anterior		Revisión del 19:24 23 feb 2021
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	**Decreased absorption		**Decreased absorption
	***Tropical sprue		***Tropical sprue
	***Drugs ([[phenytoin]], sulfasalazine, [[trimethoprim-sulfamethoxazole]]		***Drugs ([[phenytoin]], sulfasalazine, [[trimethoprim-sulfamethoxazole]])
	**Increased requirement		**Increased requirement
	***Chronic [[hemolytic anemia]]		***Chronic [[hemolytic anemia]]

ClaireLewis at 17:03, 29 September 2019

2019-09-29T17:03:28Z

← Revisión anterior		Revisión del 17:03 29 sep 2019
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	==Background==		==Background==
	*Also known as folate, folic acid		*Also known as [[folate]], folic acid
	*Necessary for normal erythropoiesis, purine and thymidylate synthesis, amino acids metabolism, and histidine metabolism		*Necessary for normal erythropoiesis, purine and thymidylate synthesis, amino acids metabolism, and histidine metabolism
	*Found in most fruits and vegetables		*Found in most fruits and vegetables
Línea 8:		Línea 8:
	===Causes===		===Causes===
	*Most common cause of deficiency is inadequate dietary intake, usually secondary to:		*Most common cause of deficiency is inadequate dietary intake, usually secondary to:
	**Chronic alcohol abuse		**Chronic [[alcohol Abuse\|alcohol abuse]]
	**Anorexia		**[[anorexia nervosa\|Anorexia]]
	**Inadequate or overcooked fruit/vegetable intake		**Inadequate or overcooked fruit/vegetable intake
	*Other causes:		*Other causes:
Línea 17:		Línea 17:
	**Increased requirement		**Increased requirement
	***Chronic [[hemolytic anemia]]		***Chronic [[hemolytic anemia]]
	***Pregnancy		***[[Pregnancy]]
	***Exfoliative skin disorders		***Exfoliative skin disorders
	**Folate loss due to hemodialysis		**Folate loss due to [[hemodialysis]]
	**Inhibition of reduction to active form (tetrahydrofolic acid) by [[methotrexate]]		**Inhibition of reduction to active form (tetrahydrofolic acid) by [[methotrexate]]

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	==Evaluation==		==Evaluation==
	*CBC		*CBC
	**Macrocytic anemia (MCV>100 fL)		**Macrocytic [[anemia]] (MCV>100 fL)
	**RDW high		**RDW high
	**Hypersegmented neutrophils		**Hypersegmented neutrophils

Rossdonaldson1: /* Background */

2018-10-22T02:29:33Z

Background

← Revisión anterior		Revisión del 02:29 22 oct 2018
Línea 5:		Línea 5:
	*Recommended daily intake: 400 mcg or 500-600mcg if pregnant or lactating		*Recommended daily intake: 400 mcg or 500-600mcg if pregnant or lactating
	*Total body stores of folate enough to supply requirements for 2–3 mo		*Total body stores of folate enough to supply requirements for 2–3 mo

			===Causes===
	*Most common cause of deficiency is inadequate dietary intake, usually secondary to:		*Most common cause of deficiency is inadequate dietary intake, usually secondary to:
	**Chronic alcohol abuse		**Chronic alcohol abuse

ClaireLewis: Created page with "==Background== Also known as folate, folic acid Necessary for normal erythropoiesis, purine and thymidylate synthesis, amino acids metabolism, and histidine metabolism *Foun..."

2016-12-22T22:42:32Z

Created page with "==Background== *Also known as folate, folic acid *Necessary for normal erythropoiesis, purine and thymidylate synthesis, amino acids metabolism, and histidine metabolism *Foun..."

Página nueva

==Background==
*Also known as folate, folic acid
*Necessary for normal erythropoiesis, purine and thymidylate synthesis, amino acids metabolism, and histidine metabolism
*Found in most fruits and vegetables
*Recommended daily intake: 400 mcg or 500-600mcg if pregnant or lactating
*Total body stores of folate enough to supply requirements for 2–3 mo
*Most common cause of deficiency is inadequate dietary intake, usually secondary to:
**Chronic alcohol abuse
**Anorexia
**Inadequate or overcooked fruit/vegetable intake
*Other causes:
**Decreased absorption
***Tropical sprue
***Drugs ([[phenytoin]], sulfasalazine, [[trimethoprim-sulfamethoxazole]]
**Increased requirement
***Chronic [[hemolytic anemia]]
***Pregnancy
***Exfoliative skin disorders
**Folate loss due to hemodialysis
**Inhibition of reduction to active form (tetrahydrofolic acid) by [[methotrexate]]

==Clinical Features==
*Signs/symptoms of [[anemia]] which may be severe
*Glossitis
*Vague GI disturbances (e.g. anorexia, [[diarrhea]])
*'''No''' neurologic features (unlike B12 deficiency)

==Differential Diagnosis==
{{Anemia DDX}}

==Evaluation==
*CBC
**Macrocytic anemia (MCV>100 fL)
**RDW high
**Hypersegmented neutrophils
*Red blood cell folate level < 150 ng/mL

==Management==
*[[Folate]]: up to 1mg IV/IM or PO daily
**Maintenance: 0.4mg/day PO (non-pregnant/lactating) or 0.8mg/day PO (pregnant or lactating)

==Disposition==

==See Also==
*[[Vitamin deficiencies]]
*[[Folic acid]]
*[[Anemia]]

==External Links==

==References==
<references/>

[[Category: FEN]]