Vancomycin - Revision history

Danbot: Strip excess bold

2026-03-22T09:15:53Z

Strip excess bold

← Revisión anterior		Revisión del 09:15 22 mar 2026
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	*15-20mg/kg IV loading dose<ref>Ryback M, et al. Therapeutic monitoring of vancomycin in adult patients: a consensus review of the American Society of Health-System Pharmacists, the Infectious Diseases Society of America, and the Society of Infectious Diseases Pharmacists. Am J Health Syst Pharm. 2009; 66(1):82-98. </ref>		*15-20mg/kg IV loading dose<ref>Ryback M, et al. Therapeutic monitoring of vancomycin in adult patients: a consensus review of the American Society of Health-System Pharmacists, the Infectious Diseases Society of America, and the Society of Infectious Diseases Pharmacists. Am J Health Syst Pharm. 2009; 66(1):82-98. </ref>
	*Sample Loading Dose Table (individual ED guidelines may differ)		*Sample Loading Dose Table (individual ED guidelines may differ)
	**~~'''~~<40kg:~~'''~~ 750mg IV		**<40kg: 750mg IV
	**~~'''~~40-59kg:~~'''~~ 1000mg IV		**40-59kg: 1000mg IV
	**~~'''~~60-90kg:~~'''~~ 1500mg IV		**60-90kg: 1500mg IV
	**~~'''~~>90kg:~~'''~~ 2000mg IV		**>90kg: 2000mg IV
	*Alternative loading dose for serious infections: 20-25mg/kg IV		*Alternative loading dose for serious infections: 20-25mg/kg IV
	*Loading doses of 30mg/kg has shown improved target trough levels at 12 hrs with no difference in nephrotoxicity<ref>Rosini JM, et al. A randomized trial of loading vancomycin in the emergency department. Ann Pharmacother. 2015; 49(1):6-13.</ref><ref>Rosini JM, et al. High single-dose vancomycin loading is not associated with increased nephrotoxicity in emergency department sepsis patients. Acad Emerg Med. 2016 Feb 6.</ref>		*Loading doses of 30mg/kg has shown improved target trough levels at 12 hrs with no difference in nephrotoxicity<ref>Rosini JM, et al. A randomized trial of loading vancomycin in the emergency department. Ann Pharmacother. 2015; 49(1):6-13.</ref><ref>Rosini JM, et al. High single-dose vancomycin loading is not associated with increased nephrotoxicity in emergency department sepsis patients. Acad Emerg Med. 2016 Feb 6.</ref>
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	===Maintenance===		===Maintenance===
	~~'''~~All: Adjust repeat doses based on serum levels~~'''~~		All: Adjust repeat doses based on serum levels
	*~~'''~~<50kg:~~'''~~ 500mg IV q12h		*<50kg: 500mg IV q12h
	*~~'''~~50-69kg:~~'''~~ 750mg IV q12h		*50-69kg: 750mg IV q12h
	*~~'''~~>70kg:~~'''~~ 1000mg IV q12h		*>70kg: 1000mg IV q12h
	*Alternative (All Weights): 10-15mg/kg IV q12		*Alternative (All Weights): 10-15mg/kg IV q12
	*Adjust dose based on serum levels		*Adjust dose based on serum levels
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	==Pediatric Dosing==		==Pediatric Dosing==
	~~'''~~All: Adjust repeat doses based on serum levels~~'''~~		All: Adjust repeat doses based on serum levels

	===General (<7 Days Old)===		===General (<7 Days Old)===
	*~~'''~~<1.2kg~~'''~~		*<1.2kg
	**15mg/kg IV q24h		**15mg/kg IV q24h
	**First Dose: 15mg/kg IV x 1		**First Dose: 15mg/kg IV x 1
	*~~'''~~1.2-2kg~~'''~~		*1.2-2kg
	**10-15mg/kg IV q12-18h		**10-15mg/kg IV q12-18h
	**First Dose: 10-15mg/kg IV x 1		**First Dose: 10-15mg/kg IV x 1
	*~~'''~~>2.1kg~~'''~~		*>2.1kg
	**10-15mg/kg IV q8-12h		**10-15mg/kg IV q8-12h
	**First Dose: 10-15mg/kg IV x 1		**First Dose: 10-15mg/kg IV x 1

	===General (7 Days - 1 Month Old)===		===General (7 Days - 1 Month Old)===
	*~~'''~~<1.2kg~~'''~~		*<1.2kg
	**15mg/kg IV q24h		**15mg/kg IV q24h
	**First Dose: 15mg/kg IV x 1		**First Dose: 15mg/kg IV x 1
	*~~'''~~1.2-2kg~~'''~~		*1.2-2kg
	**10-15mg/kg IV q8-12h		**10-15mg/kg IV q8-12h
	**First Dose: 10-15mg/kg IV x 1		**First Dose: 10-15mg/kg IV x 1
	*~~'''~~>2.1kg~~'''~~		*>2.1kg
	**15-20mg/kg IV q8		**15-20mg/kg IV q8
	**First Dose: 15-20mg/kg IV x 1		**First Dose: 15-20mg/kg IV x 1

Danbot: Remove disease-specific entries now covered by AntibioticDose (3 sections)

2026-03-20T11:07:36Z

Remove disease-specific entries now covered by AntibioticDose (3 sections)

← Revisión anterior		Revisión del 11:07 20 mar 2026
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	*Adjust dose based on serum levels		*Adjust dose based on serum levels

	~~===Staphylococcal Enterocolitis===~~
	*500-2000mg/day PO divided q6-8h x 7-10 days
	*First Dose: 500mg PO x 1

	===Indications by Disease===		===Indications by Disease===
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	*Info: Repeat dosing may require up to 1200-1500mg IV q12h or 10mg/kg IV q8		*Info: Repeat dosing may require up to 1200-1500mg IV q12h or 10mg/kg IV q8

	~~===[[Clostridium Difficile]]===~~
	*40mg/kg/day PO divided q6-8h x 7-10 days
	*First Dose: 10-13mg/kg x 1
	*Max 500mg/dose, 2000mg/day
	*For severe infection or recurrence
	*May use in combination with [[metronidazole]] PO

	~~===Staphylococcal Enterocolitis===~~
	*40mg/kg/day PO divided q6-8h x 7-10 days
	*First Dose: 10-13mg/kg x 1
	*Max 500mg/dose, 2000mg/day

	===Indications by Disease===		===Indications by Disease===

Danbot: Remove disease-specific dosing now covered by dynamic SMW tables; keep general/uncovered entries

2026-03-20T02:50:29Z

Remove disease-specific dosing now covered by dynamic SMW tables; keep general/uncovered entries

@@ Línea 26: / Línea 26: @@
 *Alternative (All Weights): 10-15mg/kg IV q12
 *Adjust dose based on serum levels
 ===Staphylococcal Enterocolitis===
@@ Línea 104: / Línea 90: @@
 *First Dose: 10-13mg/kg x 1
 *Max 500mg/dose, 2000mg/day
 ===Indications by Disease===

Danbot: Restore manual loading/maintenance/pediatric dosing alongside dynamic SMW tables

2026-03-20T02:34:29Z

Restore manual loading/maintenance/pediatric dosing alongside dynamic SMW tables

@@ Línea 1: / Línea 1: @@
 ==General==
 *Type: [[Is DrugClass::Glycopeptide]]
 *Dosage Forms:
 **IV
 **PO: Mix IV form with 30mL water
 **PR: Mix IV form with 100mL NS
 *Common Trade Names: Vancocin
 ==Adult Dosing==
 ===Indications by Disease===
 {{#ask: [[Has DrugName::Vancomycin]] [[Has Population::Adult]]
-|?Treats disease=Disease
+ |?Treats disease=Disease
-|?Has Dose=Dose
+ |?Has Dose=Dose
-|?Has Context=Context
+ |?Has Context=Context
-|format=table
+ |format=table
-|limit=50
+ |limit=50
-|mainlabel=-
+ |mainlabel=-
-|headers=show
+ |headers=show
-|sort=Treats disease
+ |sort=Treats disease
 }}
 ==Pediatric Dosing==
 ===Indications by Disease===
 {{#ask: [[Has DrugName::Vancomycin]] [[Has Population::Pediatric]]
-|?Treats disease=Disease
+ |?Treats disease=Disease
-|?Has Dose=Dose
+ |?Has Dose=Dose
-|?Has Context=Context
+ |?Has Context=Context
-|format=table
+ |format=table
-|limit=50
+ |limit=50
-|mainlabel=-
+ |mainlabel=-
-|headers=show
+ |headers=show
-|sort=Treats disease
+ |sort=Treats disease
 }}

Danbot: Replace manual dosing with dynamic SMW tables (Adult + Pediatric)

2026-03-20T01:51:14Z

Replace manual dosing with dynamic SMW tables (Adult + Pediatric)

@@ Línea 8: / Línea 8: @@
 ==Adult Dosing==
+===Indications by Disease===
-===Loading Doses===
+{{#ask: [[Has DrugName::Vancomycin]] [[Has Population::Adult]]
-*15-20mg/kg IV loading dose<ref>Ryback M, et al. Therapeutic monitoring of vancomycin in adult patients: a consensus review of the American Society of Health-System Pharmacists, the Infectious Diseases Society of America, and the Society of Infectious Diseases Pharmacists. Am J Health Syst Pharm. 2009; 66(1):82-98. </ref>
+|?Treats disease=Disease
-*Sample Loading Dose Table (individual ED guidelines may differ)
+|?Has Dose=Dose
-**'''<40kg:'''  750mg IV
+|?Has Context=Context
-**'''40-59kg:'''  1000mg IV
+|format=table
-**'''60-90kg:'''  1500mg IV
+|limit=50
-**'''>90kg:'''  2000mg IV
+|mainlabel=-
-*Alternative loading dose for serious infections: 20-25mg/kg IV
+|headers=show
-*Loading doses of 30mg/kg has shown improved target trough levels at 12 hrs with no difference in nephrotoxicity<ref>Rosini JM, et al. A randomized trial of loading vancomycin in the emergency department. Ann Pharmacother. 2015; 49(1):6-13.</ref><ref>Rosini JM, et al. High single-dose vancomycin loading is not associated with increased nephrotoxicity in emergency department sepsis patients. Acad Emerg Med. 2016 Feb 6.</ref>
+|sort=Treats disease
-*Adjust maintenance dose based on serum levels
+}}
 ==Pediatric Dosing==
-'''All: Adjust repeat doses based on serum levels'''
+===Indications by Disease===
+{{#ask: [[Has DrugName::Vancomycin]] [[Has Population::Pediatric]]
-===General (<7 Days Old)===
+|?Treats disease=Disease
-*'''<1.2kg'''
+|?Has Dose=Dose
-**15mg/kg IV q24h
+|?Has Context=Context
-**First Dose: 15mg/kg IV x 1
+|format=table
-*'''1.2-2kg'''
+|limit=50
-**10-15mg/kg IV q12-18h
+|mainlabel=-
-**First Dose: 10-15mg/kg IV x 1
+|headers=show
-*'''>2.1kg'''
+|sort=Treats disease
-**10-15mg/kg IV q8-12h
+}}
 ==Special Populations==

Ostermayer: /* Antibiotic SensitivitiesSanford Guide to Antimicrobial Therapy 2014 */

2025-08-30T13:18:09Z

Antibiotic SensitivitiesSanford Guide to Antimicrobial Therapy 2014

← Revisión anterior		Revisión del 13:18 30 ago 2025
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	\| \|\|[[MSSA]]\|\|'''S'''		\| \|\|[[MSSA]]\|\|'''S'''
	\|-		\|-
	\| \|\|[[MRSA]]\|\|'''S'''		\| \|\|[[MRSA]]\|\|'''[[Has MRSA::S]]'''
	\|-		\|-
	\| \|\|[[CA-MRSA]]\|\|'''S'''		\| \|\|[[CA-MRSA]]\|\|'''S'''

Ostermayer: /* General */

2025-08-30T12:40:20Z

General

← Revisión anterior		Revisión del 12:40 30 ago 2025
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	==General==		==General==
	*Type: [[Is DrugClass::~~Glycopeptides~~]]		*Type: [[Is DrugClass::Glycopeptide]]
	*Dosage Forms:		*Dosage Forms:
	**IV		**IV

Ostermayer: /* General */

2025-08-30T12:19:04Z

General

← Revisión anterior		Revisión del 12:19 30 ago 2025
Línea 1:		Línea 1:
	==General==		==General==
	*Type: [[Glycopeptides]]		*Type: [[Is DrugClass::Glycopeptides]]
	*Dosage Forms:		*Dosage Forms:
	**IV		**IV

Rossdonaldson1: /* Common */

2023-05-17T18:51:14Z

Common

← Revisión anterior		Revisión del 18:51 17 may 2023
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	===Common===		===Common===
	*Vancomycin infusion reaction (rapid IV use) - formerly "red man syndrome"<ref>Alvarez-Arango, S, Ogunwole, SM, Sequist, TD, Burk, CM, Blumenthal, KG. Vancomycin infusion reaction—moving beyond “red man syndrome.” N Engl J Med. 2021;384:1283-1286. doi:10.1056/NEJMp2031891</ref>		*[[Vancomycin infusion reaction]] (rapid IV use) - formerly "red man syndrome"<ref>Alvarez-Arango, S, Ogunwole, SM, Sequist, TD, Burk, CM, Blumenthal, KG. Vancomycin infusion reaction—moving beyond “red man syndrome.” N Engl J Med. 2021;384:1283-1286. doi:10.1056/NEJMp2031891</ref>
	*[[Hypotension]](rapid IV use)		*[[Hypotension]](rapid IV use)
	*[[Fever]]		*[[Fever]]

Rossdonaldson1: /* See Also */

2023-05-17T18:50:53Z

← Revisión anterior		Revisión del 18:50 17 may 2023
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	==See Also==		==See Also==
	*[[Antibiotics (Main)]]		*[[Antibiotics (Main)]]
			*[[Vancomycin infusion reaction]]

	==References==		==References==