Rossdonaldson1: /* Pediatric Dosing */

2022-12-07T20:40:58Z

Pediatric Dosing

← Revisión anterior		Revisión del 20:40 7 dic 2022
Línea 11:		Línea 11:

	==Pediatric Dosing==		==Pediatric Dosing==
			===[[Metabolic acidosis]]===
	* Infants, Children, and Adolescents: IV: Empiric dosage calculation equation based upon base deficit:		* Infants, Children, and Adolescents: IV: Empiric dosage calculation equation based upon base deficit:
	* Dose (mL) of THAM = body weight (kg) x base deficit (mEq/L) x 1.1*		* Dose (mL) of THAM = body weight (kg) x base deficit (mEq/L) x 1.1*

Rossdonaldson1: /* Adult Dosing */

2022-12-07T20:40:49Z

Adult Dosing

← Revisión anterior		Revisión del 20:40 7 dic 2022
Línea 6:		Línea 6:

	==Adult Dosing==		==Adult Dosing==
			===[[Metabolic acidosis]]===
	*Estimated dose when buffer base deficit is known: IV: tromethamine dose (mL of 0.3 M solution) = body weight (kg) x base deficit (mEq/L) x 1.1.		*Estimated dose when buffer base deficit is known: IV: tromethamine dose (mL of 0.3 M solution) = body weight (kg) x base deficit (mEq/L) x 1.1.
	*Initial: 111 to 333 mL of 0.3 M solution (3.6 to 10.8 g); additional amounts may be required to control acidosis after arrest reversed.		*Initial: 111 to 333 mL of 0.3 M solution (3.6 to 10.8 g); additional amounts may be required to control acidosis after arrest reversed.

Zbuchwald: Created page with "==Administration== Type: Tham: 30 mEq/100 mL (500 mL) [latex free] Dosage Forms: Routes of Administration: IV Common Trade Names: THAM ==Adult Dosing== Estimated dose when buffer base deficit is known: IV: tromethamine dose (mL of 0.3 M solution) = body weight (kg) x base deficit (mEq/L) x 1.1. Initial: 111 to 333 mL of 0.3 M solution (3.6 to 10.8 g); additional amounts may be required to control acidosis after arrest reversed. ==Pediatric Dosing== * Infants, Chi..."

2022-11-29T09:28:43Z

Created page with "==Administration== *Type: Tham: 30 mEq/100 mL (500 mL) [latex free] *Dosage Forms: *Routes of Administration: IV *Common Trade Names: THAM ==Adult Dosing== *Estimated dose when buffer base deficit is known: IV: tromethamine dose (mL of 0.3 M solution) = body weight (kg) x base deficit (mEq/L) x 1.1. *Initial: 111 to 333 mL of 0.3 M solution (3.6 to 10.8 g); additional amounts may be required to control acidosis after arrest reversed. ==Pediatric Dosing== * Infants, Chi..."

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==Administration==
*Type: Tham: 30 mEq/100 mL (500 mL) [latex free]
*Dosage Forms:
*Routes of Administration: IV
*Common Trade Names: THAM

==Adult Dosing==
*Estimated dose when buffer base deficit is known: IV: tromethamine dose (mL of 0.3 M solution) = body weight (kg) x base deficit (mEq/L) x 1.1.
*Initial: 111 to 333 mL of 0.3 M solution (3.6 to 10.8 g); additional amounts may be required to control acidosis after arrest reversed.

==Pediatric Dosing==
* Infants, Children, and Adolescents: IV: Empiric dosage calculation equation based upon base deficit:
* Dose (mL) of THAM = body weight (kg) x base deficit (mEq/L) x 1.1*

==Special Populations==
===[[Drug pregnancy categories|Pregnancy Rating]]===
*Unknown

===Lactation risk===
*Unknwon

===Renal Dosing===
*Adult: There are no dosage adjustments provided in the manufacturer’s labeling.
*Pediatric: There are no dosage adjustments provided in the manufacturer’s labeling.

===Hepatic Dosing===
*Adult: There are no dosage adjustments provided in the manufacturer’s labeling.
*Pediatric: There are no dosage adjustments provided in the manufacturer’s labeling.

==Contraindications==
*Allergy to class/drug
*Uremia or anuria; chronic respiratory acidosis (neonates); salicylate intoxication (neonates).

==Adverse Reactions==
===Serious===
*Extravasation: Vesicant; ensure proper needle or catheter placement prior to and during administration; avoid extravasation. May cause tissue inflammation, sloughing, and necrosis.
*Hypoglycemia: May cause hypoglycemia with rapid administration or extremely large doses; monitor serum blood glucose during and after therapy.
*Respiratory depression: Large doses may decrease respiratory ventilation due to increased blood pH and reduced CO2; adjust dose so that blood pH is not increased above normal. Monitor closely especially if patient not intubated. In patients with concomitant respiratory acidosis, use only with mechanical ventilation.

===Common===

==Pharmacology==
*Half-life:
*Metabolism: None known.
*Excretion: Urine (>75%) within 8 hours.

==Mechanism of Action==
*Acts as a proton acceptor, which combines with hydrogen ions, liberating bicarbonate buffer, to correct acidosis. It buffers both metabolic and respiratory acids, limiting carbon dioxide generation. Also an osmotic diuretic.

==Comments==

==See Also==

==References==
<references/>

[[Category:Pharmacology]]

Tromethamine - Revision history

Rossdonaldson1: /* Pediatric Dosing */

Rossdonaldson1: /* Adult Dosing */