Thiopental - Revision history

ClaireLewis: /* References */

2019-09-23T22:59:09Z

References

← Revisión anterior		Revisión del 22:59 23 sep 2019
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	<references/>		<references/>
	[[Category:Pharmacology]]		[[Category:Pharmacology]]
			[[Category:Critical Care]]

Mholtz: Text replacement - "prn" to "PRN"

2017-07-07T10:22:37Z

Text replacement - "prn" to "PRN"

← Revisión anterior		Revisión del 10:22 7 jul 2017
Línea 7:		Línea 7:
	==Adult Dosing==		==Adult Dosing==
	*Rapid anesthesia induction: 210 to 280mg (3 to 4 mg/kg) IV divided in 2 to 4 doses		*Rapid anesthesia induction: 210 to 280mg (3 to 4 mg/kg) IV divided in 2 to 4 doses
	*Anesthesia maintenance: 25-50mg IV repeated ~~prn~~ '''OR''' continuous IV infusion of 0.2% or 0.4% solution		*Anesthesia maintenance: 25-50mg IV repeated PRN '''OR''' continuous IV infusion of 0.2% or 0.4% solution
	*Raised ICP: 1.5-3.5 mg/kg IV bolus, repeat ~~prn~~		*Raised ICP: 1.5-3.5 mg/kg IV bolus, repeat PRN
	*Seizure: 75-125 mg IV given in single dose		*Seizure: 75-125 mg IV given in single dose
	*Seizure due to local anesthetic: 125-250mg IV over 10 min		*Seizure due to local anesthetic: 125-250mg IV over 10 min
Línea 17:		Línea 17:
	**1mo-1yr: 5 to 8 mg/kg IV		**1mo-1yr: 5 to 8 mg/kg IV
	**1-15yo: 5 to 6 mg/kg IV		**1-15yo: 5 to 6 mg/kg IV
	*Anesthesia maintenance, 1-15yo: 1mg/kg IV repeated ~~prn~~		*Anesthesia maintenance, 1-15yo: 1mg/kg IV repeated PRN

	==Special Populations==		==Special Populations==

Mholtz: Text replacement - "OR" to "'''OR'''"

2017-05-30T23:55:31Z

Text replacement - "OR" to "'''OR'''"

← Revisión anterior		Revisión del 23:55 30 may 2017
Línea 7:		Línea 7:
	==Adult Dosing==		==Adult Dosing==
	*Rapid anesthesia induction: 210 to 280mg (3 to 4 mg/kg) IV divided in 2 to 4 doses		*Rapid anesthesia induction: 210 to 280mg (3 to 4 mg/kg) IV divided in 2 to 4 doses
	*Anesthesia maintenance: 25-50mg IV repeated prn OR continuous IV infusion of 0.2% or 0.4% solution		*Anesthesia maintenance: 25-50mg IV repeated prn '''OR''' continuous IV infusion of 0.2% or 0.4% solution
	*Raised ICP: 1.5-3.5 mg/kg IV bolus, repeat prn		*Raised ICP: 1.5-3.5 mg/kg IV bolus, repeat prn
	*Seizure: 75-125 mg IV given in single dose		*Seizure: 75-125 mg IV given in single dose

ClaireLewis: Created page with "==Administration== Type: Barbiturate Dosage Forms: Routes of Administration: IV Common Trade Names: ==Adult Dosing== *Rapid anesthesia induction: 210 to 280mg (3 to..."

2016-11-14T00:20:15Z

Created page with "==Administration== *Type: Barbiturate *Dosage Forms: *Routes of Administration: IV *Common Trade Names: ==Adult Dosing== *Rapid anesthesia induction: 210 to 280mg (3 to..."

Página nueva

==Administration==
*Type: [[Barbiturate]]
*Dosage Forms:
*Routes of Administration: IV
*Common Trade Names:

==Adult Dosing==
*Rapid anesthesia induction: 210 to 280mg (3 to 4 mg/kg) IV divided in 2 to 4 doses
*Anesthesia maintenance: 25-50mg IV repeated prn OR continuous IV infusion of 0.2% or 0.4% solution
*Raised ICP: 1.5-3.5 mg/kg IV bolus, repeat prn
*Seizure: 75-125 mg IV given in single dose
*Seizure due to local anesthetic: 125-250mg IV over 10 min

==Pediatric Dosing==
*Anesthesia induction:
**Neonate: 3 to 4 mg/kg IV
**1mo-1yr: 5 to 8 mg/kg IV
**1-15yo: 5 to 6 mg/kg IV
*Anesthesia maintenance, 1-15yo: 1mg/kg IV repeated prn

==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: C
*[[Lactation risk categories|Lactation risk]]: Infant risk minimal
*Renal dosing: for severe impairment, give 75% of usual dose
*Hepatic dosing:

==Contraindications==
*Allergy to class/drug
*acute intermittent porphyria or variegate porphyria

==Adverse Reactions==
===Serious===
*Respiratory depression, apnea, laryngeal spasm
*Myocardial dysfunction
*Hemolytic anemia
*Raised ICP
*Radial neuropathy
===Common===
*Injection site reaction

==Pharmacology==
*Half-life: 3-18h
*Metabolism: Hepatic
*Excretion: Renal

==Mechanism of Action==
*Ultra-short acting barbiturate, GABA-agonist

==Comments==

==See Also==
*[[Barbiturates]]
*[[Barbiturate toxicity]], [[Barbiturate withdrawal]]

==References==
<references/>
[[Category:Pharmacology]]

Thiopental - Revision history

ClaireLewis: /* References */

Mholtz: Text replacement - "prn" to "PRN"

Mholtz: Text replacement - "OR" to "'''OR'''"

ClaireLewis: Created page with "==Administration== *Type: Barbiturate *Dosage Forms: *Routes of Administration: IV *Common Trade Names: ==Adult Dosing== *Rapid anesthesia induction: 210 to 280mg (3 to..."

ClaireLewis: Created page with "==Administration== Type: Barbiturate Dosage Forms: Routes of Administration: IV Common Trade Names: ==Adult Dosing== *Rapid anesthesia induction: 210 to 280mg (3 to..."