Template:Toxoplasmosis Antibiotics - Revision history

Danbot: Add congenital and pediatric dosing section

2026-03-20T13:13:49Z

Add congenital and pediatric dosing section

← Revisión anterior		Revisión del 13:13 20 mar 2026
Línea 21:		Línea 21:
	**[[Leucovorin]] 10-25 mg/day orally to prevent bone marrow suppression		**[[Leucovorin]] 10-25 mg/day orally to prevent bone marrow suppression
	*{{AntibioticDose\|drug=Dapsone\|dose=50mg PO QD; Off label use\|context=Toxoplasmosis prophylaxis\|disease=Toxoplasmosis\|population=Adult}}		*{{AntibioticDose\|drug=Dapsone\|dose=50mg PO QD; Off label use\|context=Toxoplasmosis prophylaxis\|disease=Toxoplasmosis\|population=Adult}}

			====Congenital/Pediatric====
			*{{AntibioticDose\|disease=Toxoplasmosis\|drug=Pyrimethamine\|dose=2mg/kg/day PO x 2 days then 1mg/kg/day x 2-6 months, then 1mg/kg MWF\|context=Congenital/Pediatric\|population=Pediatric}} AND
			**{{AntibioticDose\|disease=Toxoplasmosis\|drug=Sulfadiazine\|dose=50mg/kg PO BID\|context=Congenital/Pediatric\|population=Pediatric}} AND
			**{{AntibioticDose\|disease=Toxoplasmosis\|drug=Leucovorin\|dose=10mg PO 3x/week\|context=Congenital/Pediatric adjunct\|population=Pediatric}}
			*Duration: 12 months for congenital toxoplasmosis
			*Alternative: {{AntibioticDose\|disease=Toxoplasmosis\|drug=Trimethoprim-Sulfamethoxazole DS\|display=TMP/SMX\|dose=5mg/kg (TMP) PO/IV q12hrs\|context=Pediatric Immunosuppressed alt\|population=Pediatric}}
			*{{AntibioticDose\|disease=Toxoplasmosis\|drug=Clindamycin\|dose=20-30mg/kg/day PO/IV divided q6hrs (max 2.4g/day)\|context=Pediatric Sulfa Allergy alt\|population=Pediatric}} if sulfa allergic
			*{{AntibioticDose\|disease=Toxoplasmosis\|drug=Spiramycin\|dose=50-100mg/kg/day PO divided q8hrs\|context=Pediatric/Congenital alt\|population=Pediatric}}

Danbot: Add AntibioticDose entries: Dapsone

2026-03-20T10:54:33Z

Add AntibioticDose entries: Dapsone

← Revisión anterior		Revisión del 10:54 20 mar 2026
Línea 20:		Línea 20:
	*[[Pyrimethamine]] (25 mg/day orally) and sulfadiazine (4 g/day orally) divided 2 or 4 times daily until delivery AND		*[[Pyrimethamine]] (25 mg/day orally) and sulfadiazine (4 g/day orally) divided 2 or 4 times daily until delivery AND
	**[[Leucovorin]] 10-25 mg/day orally to prevent bone marrow suppression		**[[Leucovorin]] 10-25 mg/day orally to prevent bone marrow suppression
			*{{AntibioticDose\|drug=Dapsone\|dose=50mg PO QD; Off label use\|context=Toxoplasmosis prophylaxis\|disease=Toxoplasmosis\|population=Adult}}

Danbot: Convert to AntibioticDose with disease=Toxoplasmosis for SMW linking

2026-03-20T01:31:22Z

Convert to AntibioticDose with disease=Toxoplasmosis for SMW linking

← Revisión anterior		Revisión del 01:31 20 mar 2026
Línea 1:		Línea 1:
	====Immunocompetent====		====Immunocompetent====
	''Antibiotics only needed if patient has severe symptoms''		''Antibiotics only needed if patient has severe symptoms''
	*[[Pyrimethamine]] 200mg PO ~~one dose (for loading) THEN~~ 50mg PO q24hrs ~~x4wks~~ AND		*{{AntibioticDose\|disease=Toxoplasmosis\|drug=Pyrimethamine\|dose=200mg PO load then 50mg PO q24hrs x 4 weeks\|context=Immunocompetent with Leucovorin and Sulfadiazine\|population=Adult}} AND
	**[[Leucovorin]] 10mg PO q24hrs AND		**{{AntibioticDose\|disease=Toxoplasmosis\|drug=Leucovorin\|dose=10mg PO q24hrs\|context=Immunocompetent adjunct\|population=Adult}} AND
	**[[Sulfadiazine]] 1g PO q6hrs		**{{AntibioticDose\|disease=Toxoplasmosis\|drug=Sulfadiazine\|dose=1g PO q6hrs\|context=Immunocompetent with Pyrimethamine\|population=Adult}}

	====Immunosprepressed====		====Immunosprepressed====
	*[[Pyrimethamine]] 200mg PO ~~one dose (for loading) THEN~~ 75mg PO q24hrs x4-~~8wks~~ AND [[Leucovorin]] 25mg PO q24hrs PLUS		*{{AntibioticDose\|disease=Toxoplasmosis\|drug=Pyrimethamine\|dose=200mg PO load then 75mg PO q24hrs x 4-8 weeks\|context=Immunosuppressed\|population=Adult}} AND {{AntibioticDose\|disease=Toxoplasmosis\|drug=Leucovorin\|dose=25mg PO q24hrs\|context=Immunosuppressed adjunct\|population=Adult}} PLUS
	**[[Sulfadiazine]] 1500mg PO q6hrs OR		**{{AntibioticDose\|disease=Toxoplasmosis\|drug=Sulfadiazine\|dose=1500mg PO q6hrs\|context=Immunosuppressed with Pyrimethamine\|population=Adult}} OR
	**[[Clindamycin]] 600mg PO or IV q6hrs OR		**{{AntibioticDose\|disease=Toxoplasmosis\|drug=Clindamycin\|dose=600mg PO or IV q6hrs\|context=Immunosuppressed alt\|population=Adult}} OR
	**[[Azithromycin~~]] 12000mg~~ PO q24hrs OR		**{{AntibioticDose\|disease=Toxoplasmosis\|drug=Azithromycin\|dose=1200mg PO q24hrs\|context=Immunosuppressed alt\|population=Adult}} OR
	**[[Atovaquone]] 1500mg PO q12hrs		**[[Atovaquone]] 1500mg PO q12hrs
	OR		OR
	*~~[[TMP/SMX]]~~ 5mg/kg IV q12hrs		*{{AntibioticDose\|disease=Toxoplasmosis\|drug=Trimethoprim-Sulfamethoxazole DS\|dose=5mg/kg IV q12hrs\|context=Immunosuppressed alt\|display=TMP/SMX\|population=Adult}}

	====Pregnant====		====Pregnant====
	*[[Spiramycin~~]] 1 g orally every 8 hours~~<ref>Paquet C, Yudin MH. Toxoplasmosis in pregnancy: prevention, screening, and treatment. J Obstet Gynaecol Can. Jan 2013;35(1):78-9.</ref>		*{{AntibioticDose\|disease=Toxoplasmosis\|drug=Spiramycin\|dose=1g PO q8hrs\|context=Pregnant\|population=Adult}}<ref>Paquet C, Yudin MH. Toxoplasmosis in pregnancy: prevention, screening, and treatment. J Obstet Gynaecol Can. Jan 2013;35(1):78-9.</ref>
	**If amniotic fluid is positive treat with 3 weeks of pyrimethamine (50 mg/day orally) + sulfadiazine (3 g/day orally in 2-3 divided doses)		**If amniotic fluid is positive treat with 3 weeks of pyrimethamine (50 mg/day orally) + sulfadiazine (3 g/day orally in 2-3 divided doses)
	**Alternate with a 3-week course of Spiramycin 1 g 3 times daily OR		**Alternate with a 3-week course of Spiramycin 1 g 3 times daily OR
	*[[Pyrimethamine]] (25 mg/day orally) and sulfadiazine (4 g/day orally) divided 2 or 4 times daily until delivery AND		*[[Pyrimethamine]] (25 mg/day orally) and sulfadiazine (4 g/day orally) divided 2 or 4 times daily until delivery AND
	**[[Leucovorin]] 10-25 mg/day orally to prevent bone marrow suppression		**[[Leucovorin]] 10-25 mg/day orally to prevent bone marrow suppression

Ananvilhurtz: /* Immunosprepressed */

2025-12-31T00:23:18Z

Immunosprepressed

← Revisión anterior		Revisión del 00:23 31 dic 2025
Línea 6:		Línea 6:

	====Immunosprepressed====		====Immunosprepressed====
	*[[TMP/SMX]] 5mg/kg IV q12hrs OR
	*[[Pyrimethamine]] 200mg PO one dose (for loading) THEN 75mg PO q24hrs x4-8wks AND [[Leucovorin]] 25mg PO q24hrs PLUS		*[[Pyrimethamine]] 200mg PO one dose (for loading) THEN 75mg PO q24hrs x4-8wks AND [[Leucovorin]] 25mg PO q24hrs PLUS
	**[[Sulfadiazine]] 1500mg PO q6hrs OR		**[[Sulfadiazine]] 1500mg PO q6hrs OR
Línea 12:		Línea 11:
	**[[Azithromycin]] 12000mg PO q24hrs OR		**[[Azithromycin]] 12000mg PO q24hrs OR
	**[[Atovaquone]] 1500mg PO q12hrs		**[[Atovaquone]] 1500mg PO q12hrs
			OR
			*[[TMP/SMX]] 5mg/kg IV q12hrs

	====Pregnant====		====Pregnant====

ClaireLewis: /* Pregnant */

2017-08-31T20:16:22Z

Pregnant

← Revisión anterior		Revisión del 20:16 31 ago 2017
Línea 14:		Línea 14:

	====Pregnant====		====Pregnant====
	*Spiramycin 1 g orally every 8 hours<ref>Paquet C, Yudin MH. Toxoplasmosis in pregnancy: prevention, screening, and treatment. J Obstet Gynaecol Can. Jan 2013;35(1):78-9.</ref>		*[[Spiramycin]] 1 g orally every 8 hours<ref>Paquet C, Yudin MH. Toxoplasmosis in pregnancy: prevention, screening, and treatment. J Obstet Gynaecol Can. Jan 2013;35(1):78-9.</ref>
	**If amniotic fluid is positive treat with 3 weeks of pyrimethamine (50 mg/day orally) + sulfadiazine (3 g/day orally in 2-3 divided doses)		**If amniotic fluid is positive treat with 3 weeks of pyrimethamine (50 mg/day orally) + sulfadiazine (3 g/day orally in 2-3 divided doses)
	**Alternate with a 3-week course of Spiramycin 1 g 3 times daily OR		**Alternate with a 3-week course of Spiramycin 1 g 3 times daily OR
	*Pyrimethamine (25 mg/day orally) and sulfadiazine (4 g/day orally) divided 2 or 4 times daily until delivery AND		*[[Pyrimethamine]] (25 mg/day orally) and sulfadiazine (4 g/day orally) divided 2 or 4 times daily until delivery AND
	**Leucovorin 10-25 mg/day orally to prevent bone marrow suppression		**[[Leucovorin]] 10-25 mg/day orally to prevent bone marrow suppression

Kxl328 at 01:14, 12 December 2015

2015-12-12T01:14:37Z

← Revisión anterior		Revisión del 01:14 12 dic 2015
Línea 7:		Línea 7:
	====Immunosprepressed====		====Immunosprepressed====
	*[[TMP/SMX]] 5mg/kg IV q12hrs OR		*[[TMP/SMX]] 5mg/kg IV q12hrs OR
	*[[Pyrimethamine]] 200mg PO one dose (for loading) THEN 75mg PO ~~q2h4s~~ AND [[Leucovorin]] 25mg PO q24hrs PLUS		*[[Pyrimethamine]] 200mg PO one dose (for loading) THEN 75mg PO q24hrs x4-8wks AND [[Leucovorin]] 25mg PO q24hrs PLUS
	**[[Sulfadiazine]] 1500mg PO q6hrs OR		**[[Sulfadiazine]] 1500mg PO q6hrs OR
	**[[Clindamycin]] 600mg PO or IV q6hrs OR		**[[Clindamycin]] 600mg PO or IV q6hrs OR

Kxl328 at 01:14, 12 December 2015

2015-12-12T01:14:10Z

← Revisión anterior		Revisión del 01:14 12 dic 2015
Línea 1:		Línea 1:
	====Immunocompetent====		====Immunocompetent====
	''Antibiotics only needed if patient has severe symptoms''		''Antibiotics only needed if patient has severe symptoms''
	*[[Pyrimethamine]] 200mg PO one dose (for loading) THEN 50mg PO ~~q2h4s~~ AND		*[[Pyrimethamine]] 200mg PO one dose (for loading) THEN 50mg PO q24hrs x4wks AND
	**[[Leucovorin]] 10mg PO q24hrs AND		**[[Leucovorin]] 10mg PO q24hrs AND
	**[[Sulfadiazine]] 1g PO q6hrs		**[[Sulfadiazine]] 1g PO q6hrs

Yoshmd at 15:00, 19 May 2015

2015-05-19T15:00:53Z

← Revisión anterior		Revisión del 15:00 19 may 2015
Línea 12:		Línea 12:
	**[[Azithromycin]] 12000mg PO q24hrs OR		**[[Azithromycin]] 12000mg PO q24hrs OR
	**[[Atovaquone]] 1500mg PO q12hrs		**[[Atovaquone]] 1500mg PO q12hrs

			====Pregnant====
			*Spiramycin 1 g orally every 8 hours<ref>Paquet C, Yudin MH. Toxoplasmosis in pregnancy: prevention, screening, and treatment. J Obstet Gynaecol Can. Jan 2013;35(1):78-9.</ref>
			**If amniotic fluid is positive treat with 3 weeks of pyrimethamine (50 mg/day orally) + sulfadiazine (3 g/day orally in 2-3 divided doses)
			**Alternate with a 3-week course of Spiramycin 1 g 3 times daily OR
			*Pyrimethamine (25 mg/day orally) and sulfadiazine (4 g/day orally) divided 2 or 4 times daily until delivery AND
			**Leucovorin 10-25 mg/day orally to prevent bone marrow suppression

Yoshmd: Created page with "====Immunocompetent==== ''Antibiotics only needed if patient has severe symptoms'' *Pyrimethamine 200mg PO one dose (for loading) THEN 50mg PO q2h4s AND **Leucovorin 1..."

2015-05-19T14:55:51Z

Created page with "====Immunocompetent==== ''Antibiotics only needed if patient has severe symptoms'' *Pyrimethamine 200mg PO one dose (for loading) THEN 50mg PO q2h4s AND **Leucovorin 1..."

Página nueva

====Immunocompetent====
''Antibiotics only needed if patient has severe symptoms''
*[[Pyrimethamine]] 200mg PO one dose (for loading) THEN 50mg PO q2h4s AND
**[[Leucovorin]] 10mg PO q24hrs AND
**[[Sulfadiazine]] 1g PO q6hrs

====Immunosprepressed====
*[[TMP/SMX]] 5mg/kg IV q12hrs OR
*[[Pyrimethamine]] 200mg PO one dose (for loading) THEN 75mg PO q2h4s AND [[Leucovorin]] 25mg PO q24hrs PLUS
**[[Sulfadiazine]] 1500mg PO q6hrs OR
**[[Clindamycin]] 600mg PO or IV q6hrs OR
**[[Azithromycin]] 12000mg PO q24hrs OR
**[[Atovaquone]] 1500mg PO q12hrs