Template:TBI pathophysiology - Revision history

Rossdonaldson1: /* Cerebral Blood Flow and Autoregulation */

2017-11-23T14:30:15Z

Cerebral Blood Flow and Autoregulation

← Revisión anterior		Revisión del 14:30 23 nov 2017
Línea 39:		Línea 39:
	*Autoregulation allows the body to control the cerebral blood flow		*Autoregulation allows the body to control the cerebral blood flow
	**Autoregulatory mechanism is damaged in most TBI patients		**Autoregulatory mechanism is damaged in most TBI patients
	*Cushing Reflex- more common in children than adults
	**Hypertension
	**Bradycardia
	**Respiratory Irregularity

Rossdonaldson1: /* Primary injury */

2017-11-23T13:55:39Z

Primary injury

← Revisión anterior		Revisión del 13:55 23 nov 2017
Línea 2:		Línea 2:
	====Primary injury====		====Primary injury====
	*Contusions		*Contusions
	**~~bruises~~ to brain parenchyma		**Bruises to brain parenchyma
	*Hematomas		*Hematomas
	**Epidural		**[[Epidural hematoma]]
	**Subdural		**[[Subdural hematoma]]
	**Intraparenchymal		**Intraparenchymal
	**Intraventricular		**Intraventricular
	**Subarachnoid		**[[Subarachnoid hemorrhage]]
	*Diffuse ~~Axonal Injury~~		*Diffuse axonal injury
	*Direct ~~Cellular Damage~~		*Direct cellular damage
	**~~neurons~~		**Neurons
	**~~axons~~		**Axons
	*~~tearing~~ and shearing of tissues		*Tearing and shearing of tissues

	====Secondary injury====		====Secondary injury====

Rossdonaldson1: /* TBI Pathophysiology */

2017-11-23T13:48:18Z

TBI Pathophysiology

@@ Línea 1: / Línea 1: @@
 ===[[TBI]] Pathophysiology===
 ====Primary injury====
-*contusions
+*Contusions
 **bruises to brain parenchyma
 *Hematomas
@@ Línea 35: / Línea 17: @@
 ====Secondary injury====
 ''Brain swelling causes [[increased ICP]] which compresses the tissue causing ischemia with direct compression of the vasculature causing brain tissue herniation and brain death''
-*Leads to expansion of the original injury
+*Leads to expansion of the original injury (predominantly metabolic insult)
-*Calcium and ion shifts
+**Calcium and sodium shifts
-*Mitochondrial damage
+**Mitochondrial damage
-*Production of free radicals
+**Production of free radicals
 *Ultimately leads to damage to axonal integrity and axonal transport
 *Microscopic structural injury is often unidentifiable on CT or MRI

Rossdonaldson1: /* TBI Pathophysiology */

2017-11-21T23:16:41Z

TBI Pathophysiology

← Revisión anterior		Revisión del 23:16 21 nov 2017
Línea 40:		Línea 40:
	*Production of free radicals		*Production of free radicals
	*Enzyme activity that lead to apoptosis		*Enzyme activity that lead to apoptosis

			====Causes====
			*Predominantly metabolic insult
			**Mitochondrial dysfunction
			**shifts in calcium and sodium balances
			*Ultimately leads to damage to axonal integrity and axonal transport
			*Microscopic structural injury is often unidentifiable on CT or MRI

Rossdonaldson1: /* Pathophysiology */

2017-11-21T23:15:05Z

Pathophysiology

← Revisión anterior		Revisión del 23:15 21 nov 2017
Línea 18:		Línea 18:
	**Respiratory Irregularity		**Respiratory Irregularity

	~~===Pathophysiology===~~
	====Primary injury====		====Primary injury====
	*contusions		*contusions

Rossdonaldson1: /* TBI Pathophysiology */

2017-11-21T23:14:53Z

TBI Pathophysiology

← Revisión anterior		Revisión del 23:14 21 nov 2017
Línea 17:		Línea 17:
	**Bradycardia		**Bradycardia
	**Respiratory Irregularity		**Respiratory Irregularity

			===Pathophysiology===
			====Primary injury====
			*contusions
			**bruises to brain parenchyma
			*Hematomas
			**Epidural
			**Subdural
			**Intraparenchymal
			**Intraventricular
			**Subarachnoid
			*Diffuse Axonal Injury
			*Direct Cellular Damage
			**neurons
			**axons
			*tearing and shearing of tissues

			====Secondary injury====
			''Brain swelling causes [[increased ICP]] which compresses the tissue causing ischemia with direct compression of the vasculature causing brain tissue herniation and brain death''
			*Leads to expansion of the original injury
			*Calcium and ion shifts
			*Mitochondrial damage
			*Production of free radicals
			*Enzyme activity that lead to apoptosis

Rossdonaldson1: Created page with "===TBI Pathophysiology=== *vasoconstriction **HTN, Hypocarbia, alkalosis No good way to measure cerebral blood flow Use CPP as surrogate CPP is amount of pressure ne..."

2017-11-21T23:13:59Z

Created page with "===TBI Pathophysiology=== *vasoconstriction **HTN, Hypocarbia, alkalosis *No good way to measure cerebral blood flow **Use CPP as surrogate ***CPP is amount of pressure ne..."

Página nueva

===[[TBI]] Pathophysiology===
*vasoconstriction
**HTN, Hypocarbia, alkalosis
*No good way to measure cerebral blood flow
**Use CPP as surrogate
***CPP is amount of pressure needed to perfuse the brain
***CPP=MAP-ICP
****When ICP elevates, CPP decreases
****Normal ICP
*****15 in adults
*****<10 to 15 in children
*****1.5 to 6.0 in infants
*Autoregulation allows the body to control the cerebral blood flow
**Autoregulatory mechanism is damaged in most TBI patients
*Cushing Reflex- more common in children than adults
**Hypertension
**Bradycardia
**Respiratory Irregularity

Template:TBI pathophysiology - Revision history

Rossdonaldson1: /* Cerebral Blood Flow and Autoregulation */

Rossdonaldson1: /* Primary injury */

Rossdonaldson1: /* TBI Pathophysiology */

Rossdonaldson1: /* TBI Pathophysiology */

Rossdonaldson1: /* Pathophysiology */

Rossdonaldson1: /* TBI Pathophysiology */

Rossdonaldson1: Created page with "===TBI Pathophysiology=== *vasoconstriction **HTN, Hypocarbia, alkalosis *No good way to measure cerebral blood flow **Use CPP as surrogate ***CPP is amount of pressure ne..."

Rossdonaldson1: Created page with "===TBI Pathophysiology=== *vasoconstriction **HTN, Hypocarbia, alkalosis No good way to measure cerebral blood flow Use CPP as surrogate CPP is amount of pressure ne..."