Template:Repeat B-hCG levels - Revision history

Danbot: Fix references: replace {{cite journal}} with plain text format matching WikEM convention

2026-03-22T06:33:33Z

Fix references: replace {{cite journal}} with plain text format matching WikEM convention

← Revisión anterior		Revisión del 06:33 22 mar 2026
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	\|-		\|-
	\| [[Pregnancy (main)\|Normal]]\|\|		\| [[Pregnancy (main)\|Normal]]\|\|
	*Minimum expected rise depends on initial hCG value:<ref name="barnhart2004">~~{{cite journal\|author=~~Barnhart KT, Sammel MD, Rinaudo PF, et al.~~\|title=~~Symptomatic patients with an early viable intrauterine pregnancy: HCG curves redefined~~\|journal=~~Obstet Gynecol~~\|year=~~2004~~\|volume=~~104~~\|issue=~~1~~\|pages=~~50-55~~\|pmid=~~15229000}}</ref><ref name="barnhart2016">~~{{cite journal\|author=~~Barnhart KT, Guo W, Cary MS, et al.~~\|title=~~Differences in serum human chorionic gonadotropin rise in early pregnancy by race and value at presentation~~\|journal=~~Obstet Gynecol~~\|year=~~2016~~\|volume=~~128~~\|issue=~~3~~\|pages=~~504-511~~\|pmid=~~27500347}}</ref>		*Minimum expected rise depends on initial hCG value:<ref name="barnhart2004">Barnhart KT, Sammel MD, Rinaudo PF, et al. Symptomatic patients with an early viable intrauterine pregnancy: HCG curves redefined. Obstet Gynecol. 2004; 104(1):50-55. PMID 15229000.</ref><ref name="barnhart2016">Barnhart KT, Guo W, Cary MS, et al. Differences in serum human chorionic gonadotropin rise in early pregnancy by race and value at presentation. Obstet Gynecol. 2016; 128(3):504-511. PMID 27500347.</ref>
	**Initial hCG <1,500 mIU/mL: minimum 49% rise in 48hrs		**Initial hCG <1,500 mIU/mL: minimum 49% rise in 48hrs
	**Initial hCG 1,500-3,000 mIU/mL: minimum 40% rise in 48hrs		**Initial hCG 1,500-3,000 mIU/mL: minimum 40% rise in 48hrs
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	\| [[Ectopic pregnancy\|Ectopic]]\|\|		\| [[Ectopic pregnancy\|Ectopic]]\|\|
	*Increases or decreases more slowly than expected ("plateau")		*Increases or decreases more slowly than expected ("plateau")
	*Approximately 21% of ectopic pregnancies have a normal hCG rise<ref name="silva2006">~~{{cite journal\|author=~~Silva C, Sammel MD, Zhou L, et al.~~\|title=~~Human chorionic gonadotropin profile for women with ectopic pregnancy~~\|journal=~~Obstet Gynecol~~\|year=~~2006~~\|volume=~~107~~\|issue=~~3~~\|pages=~~605-610~~\|pmid=~~16507930}}</ref>		*Approximately 21% of ectopic pregnancies have a normal hCG rise<ref name="silva2006">Silva C, Sammel MD, Zhou L, et al. Human chorionic gonadotropin profile for women with ectopic pregnancy. Obstet Gynecol. 2006; 107(3):605-610. PMID 16507930.</ref>
	\|-		\|-
	\| [[Miscarriage]]\|\|		\| [[Miscarriage]]\|\|
	*Expected to decline >21-35% in 48 hrs<ref name="doubilet2013">~~{{cite journal\|author=~~Doubilet PM, Benson CB, Bourne T, Blaivas M~~\|title=~~Diagnostic criteria for nonviable pregnancy early in the first trimester~~\|journal=~~N Engl J Med~~\|year=~~2013~~\|volume=~~369~~\|issue=~~15~~\|pages=~~1443-1451~~\|pmid=~~24106937}}</ref>		*Expected to decline >21-35% in 48 hrs<ref name="doubilet2013">Doubilet PM, Benson CB, Bourne T, Blaivas M. Diagnostic criteria for nonviable pregnancy early in the first trimester. N Engl J Med. 2013; 369(15):1443-1451. PMID 24106937.</ref>
	\|}		\|}
	*A single hCG level '''cannot''' reliably distinguish intrauterine from [[ectopic pregnancy]]<ref name="murray2005">~~{{cite journal\|author=~~Murray H, Baakdah H, Bardell T, Tulandi T~~\|title=~~Diagnosis and treatment of ectopic pregnancy~~\|journal=~~CMAJ~~\|year=~~2005~~\|volume=~~173~~\|issue=~~8~~\|pages=~~905-912~~\|pmid=~~16217116}}</ref>		*A single hCG level '''cannot''' reliably distinguish intrauterine from [[ectopic pregnancy]]<ref name="murray2005">Murray H, Baakdah H, Bardell T, Tulandi T. Diagnosis and treatment of ectopic pregnancy. CMAJ. 2005; 173(8):905-912. PMID 16217116.</ref>
	*The [[Ectopic pregnancy\|discriminatory zone]] (typically 1,500-3,500 mIU/mL depending on institution) is the hCG level above which a gestational sac should be visible on transvaginal ultrasound<ref name="connolly2013">~~{{cite journal\|author=~~Connolly A, Ryan DH, Stuber AR, Postma HJ~~\|title=~~Reevaluation of discriminatory and threshold levels for serum beta-hCG in early pregnancy~~\|journal=~~Obstet Gynecol~~\|year=~~2013~~\|volume=~~121~~\|issue=~~1~~\|pages=~~65-70~~\|pmid=~~23262929}}</ref>		*The [[Ectopic pregnancy\|discriminatory zone]] (typically 1,500-3,500 mIU/mL depending on institution) is the hCG level above which a gestational sac should be visible on transvaginal ultrasound<ref name="connolly2013">Connolly A, Ryan DH, Stuber AR, Postma HJ. Reevaluation of discriminatory and threshold levels for serum beta-hCG in early pregnancy. Obstet Gynecol. 2013; 121(1):65-70. PMID 23262929.</ref>

Danbot: Fix discriminatory zone link to point to ectopic pregnancy page

2026-03-22T06:29:04Z

Fix discriminatory zone link to point to ectopic pregnancy page

← Revisión anterior		Revisión del 06:29 22 mar 2026
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	\|}		\|}
	*A single hCG level '''cannot''' reliably distinguish intrauterine from [[ectopic pregnancy]]<ref name="murray2005">{{cite journal\|author=Murray H, Baakdah H, Bardell T, Tulandi T\|title=Diagnosis and treatment of ectopic pregnancy\|journal=CMAJ\|year=2005\|volume=173\|issue=8\|pages=905-912\|pmid=16217116}}</ref>		*A single hCG level '''cannot''' reliably distinguish intrauterine from [[ectopic pregnancy]]<ref name="murray2005">{{cite journal\|author=Murray H, Baakdah H, Bardell T, Tulandi T\|title=Diagnosis and treatment of ectopic pregnancy\|journal=CMAJ\|year=2005\|volume=173\|issue=8\|pages=905-912\|pmid=16217116}}</ref>
	*The [[~~Discriminatory zone~~\|discriminatory zone]] (typically 1,500-3,500 mIU/mL depending on institution) is the hCG level above which a gestational sac should be visible on transvaginal ultrasound<ref name="connolly2013">{{cite journal\|author=Connolly A, Ryan DH, Stuber AR, Postma HJ\|title=Reevaluation of discriminatory and threshold levels for serum beta-hCG in early pregnancy\|journal=Obstet Gynecol\|year=2013\|volume=121\|issue=1\|pages=65-70\|pmid=23262929}}</ref>		*The [[Ectopic pregnancy\|discriminatory zone]] (typically 1,500-3,500 mIU/mL depending on institution) is the hCG level above which a gestational sac should be visible on transvaginal ultrasound<ref name="connolly2013">{{cite journal\|author=Connolly A, Ryan DH, Stuber AR, Postma HJ\|title=Reevaluation of discriminatory and threshold levels for serum beta-hCG in early pregnancy\|journal=Obstet Gynecol\|year=2013\|volume=121\|issue=1\|pages=65-70\|pmid=23262929}}</ref>

Danbot: Update with current evidence-based hCG rise values and add references (Barnhart 2004/2016, Silva 2006, Doubilet 2013)

2026-03-22T06:27:29Z

Update with current evidence-based hCG rise values and add references (Barnhart 2004/2016, Silva 2006, Doubilet 2013)

← Revisión anterior		Revisión del 06:27 22 mar 2026
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	===Repeat [[B-hCG]] Levels===		===Repeat [[Beta-HCG\|B-hCG]] Levels===
	{\| {{table}}		{\| {{table}}
	\| align="center" style="background:#f0f0f0;"\|'''Pregnancy Type'''		\| align="center" style="background:#f0f0f0;"\|'''Pregnancy Type'''
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	\|-		\|-
	\| [[Pregnancy (main)\|Normal]]\|\|		\| [[Pregnancy (main)\|Normal]]\|\|
	*~~Increase~~ >~~53% in 48hrs (until 10~~,~~000 mIU~~/~~ml)~~		*Minimum expected rise depends on initial hCG value:<ref name="barnhart2004">{{cite journal\|author=Barnhart KT, Sammel MD, Rinaudo PF, et al.\|title=Symptomatic patients with an early viable intrauterine pregnancy: HCG curves redefined\|journal=Obstet Gynecol\|year=2004\|volume=104\|issue=1\|pages=50-55\|pmid=15229000}}</ref><ref name="barnhart2016">{{cite journal\|author=Barnhart KT, Guo W, Cary MS, et al.\|title=Differences in serum human chorionic gonadotropin rise in early pregnancy by race and value at presentation\|journal=Obstet Gynecol\|year=2016\|volume=128\|issue=3\|pages=504-511\|pmid=27500347}}</ref>
	*Depends on the initial value:		**Initial hCG <1,500 mIU/mL: minimum 49% rise in 48hrs
	**<~~1500 --> 50~~% ~~increase~~		**Initial hCG 1,500-3,000 mIU/mL: minimum 40% rise in 48hrs
	**~~1500~~-~~3000 -->~~ 40% ~~increase~~		**Initial hCG >3,000 mIU/mL: minimum 33% rise in 48hrs
	**> ~~3000~~ --~~> 30% increase~~		*hCG typically doubles approximately every 48-72 hours in early pregnancy
			*Rate of rise slows after hCG reaches approximately 6,000-10,000 mIU/mL
	\|-		\|-
	\| [[Ectopic]]\|\|		\| [[Ectopic pregnancy\|Ectopic]]\|\|
	*Increases or decreases slowly ("plateau")^		*Increases or decreases more slowly than expected ("plateau")
			*Approximately 21% of ectopic pregnancies have a normal hCG rise<ref name="silva2006">{{cite journal\|author=Silva C, Sammel MD, Zhou L, et al.\|title=Human chorionic gonadotropin profile for women with ectopic pregnancy\|journal=Obstet Gynecol\|year=2006\|volume=107\|issue=3\|pages=605-610\|pmid=16507930}}</ref>
	\|-		\|-
	\| [[Miscarriage]]\|\|		\| [[Miscarriage]]\|\|
	*~~Decreases~~ >20% in 48 hrs		*Expected to decline >21-35% in 48 hrs<ref name="doubilet2013">{{cite journal\|author=Doubilet PM, Benson CB, Bourne T, Blaivas M\|title=Diagnostic criteria for nonviable pregnancy early in the first trimester\|journal=N Engl J Med\|year=2013\|volume=369\|issue=15\|pages=1443-1451\|pmid=24106937}}</ref>
	\|}		\|}
	~~^Initial~~ level ~~CANNOT~~ be ~~used to rule~~-~~out ectopic~~		*A single hCG level '''cannot''' reliably distinguish intrauterine from [[ectopic pregnancy]]<ref name="murray2005">{{cite journal\|author=Murray H, Baakdah H, Bardell T, Tulandi T\|title=Diagnosis and treatment of ectopic pregnancy\|journal=CMAJ\|year=2005\|volume=173\|issue=8\|pages=905-912\|pmid=16217116}}</ref>
			*The [[Discriminatory zone\|discriminatory zone]] (typically 1,500-3,500 mIU/mL depending on institution) is the hCG level above which a gestational sac should be visible on transvaginal ultrasound<ref name="connolly2013">{{cite journal\|author=Connolly A, Ryan DH, Stuber AR, Postma HJ\|title=Reevaluation of discriminatory and threshold levels for serum beta-hCG in early pregnancy\|journal=Obstet Gynecol\|year=2013\|volume=121\|issue=1\|pages=65-70\|pmid=23262929}}</ref>

Rossdonaldson1: /* Repeat B-hCG Levels */

2020-06-22T21:13:34Z

Repeat B-hCG Levels

← Revisión anterior		Revisión del 21:13 22 jun 2020
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	\| align="center" style="background:#f0f0f0;"\|'''B-hCG Change'''		\| align="center" style="background:#f0f0f0;"\|'''B-hCG Change'''
	\|-		\|-
	\| Normal\|\|		\| [[Pregnancy (main)\|Normal]]\|\|
	*Increase >53% in 48hrs (until 10,000 mIU/ml)		*Increase >53% in 48hrs (until 10,000 mIU/ml)
	*Depends on the initial value:		*Depends on the initial value:

Rossdonaldson1: /* Repeat B-hCG Levels */

2020-06-22T21:13:10Z

Repeat B-hCG Levels

← Revisión anterior		Revisión del 21:13 22 jun 2020
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	**> 3000 --> 30% increase		**> 3000 --> 30% increase
	\|-		\|-
	\| Ectopic\|\|		\| [[Ectopic]]\|\|
	*Increases or decreases slowly ("plateau")^		*Increases or decreases slowly ("plateau")^
	\|-		\|-
	\| Miscarriage\|\|		\| [[Miscarriage]]\|\|
	*Decreases >20% in 48 hrs		*Decreases >20% in 48 hrs
	\|}		\|}
	^Initial level CANNOT be used to rule-out ectopic		^Initial level CANNOT be used to rule-out ectopic

Rossdonaldson1: /* Repeat B-hCG Levels */

2020-06-22T21:12:33Z

Repeat B-hCG Levels

← Revisión anterior		Revisión del 21:12 22 jun 2020
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	\| Normal\|\|		\| Normal\|\|
	*Increase >53% in 48hrs (until 10,000 mIU/ml)		*Increase >53% in 48hrs (until 10,000 mIU/ml)
	*Depends on the initial value		*Depends on the initial value:
	**<1500 --> 50% increase		**<1500 --> 50% increase
	**1500-3000 --> 40% increase		**1500-3000 --> 40% increase

Rossdonaldson1: /* Repeat B-hCG Levels */

2020-06-22T21:12:20Z

Repeat B-hCG Levels

← Revisión anterior		Revisión del 21:12 22 jun 2020
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	\| align="center" style="background:#f0f0f0;"\|'''B-hCG Change'''		\| align="center" style="background:#f0f0f0;"\|'''B-hCG Change'''
	\|-		\|-
	\| Normal\|\|Increase >53% in 48hrs (until 10,000 mIU/ml)		\| Normal\|\|
	~~(This increase depends~~ on the initial value. <1500 --> 50% ~~inc,~~ 1500-3000 --> 40% ~~inc,~~ > 3000 --> 30% ~~inc)~~		*Increase >53% in 48hrs (until 10,000 mIU/ml)
			*Depends on the initial value
			**<1500 --> 50% increase
			**1500-3000 --> 40% increase
			**> 3000 --> 30% increase
	\|-		\|-
	\| Ectopic\|\|Increases or decreases slowly ("plateau")^		\| Ectopic\|\|
			*Increases or decreases slowly ("plateau")^
	\|-		\|-
	\| Miscarriage\|\|Decreases >20% in 48 hrs		\| Miscarriage\|\|
			*Decreases >20% in 48 hrs
	\|}		\|}
	^Initial level CANNOT be used to rule-out ectopic		^Initial level CANNOT be used to rule-out ectopic

KOkamoto: /* Repeat B-hCG Levels */

2019-04-09T17:54:59Z

Repeat B-hCG Levels

← Revisión anterior		Revisión del 17:54 9 abr 2019
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	\|-		\|-
	\| Normal\|\|Increase >53% in 48hrs (until 10,000 mIU/ml)		\| Normal\|\|Increase >53% in 48hrs (until 10,000 mIU/ml)
			(This increase depends on the initial value. <1500 --> 50% inc, 1500-3000 --> 40% inc, > 3000 --> 30% inc)
	\|-		\|-
	\| Ectopic\|\|Increases or decreases slowly ("plateau")^		\| Ectopic\|\|Increases or decreases slowly ("plateau")^

Rossdonaldson1 at 23:14, 18 December 2018

2018-12-18T23:14:47Z

← Revisión anterior		Revisión del 23:14 18 dic 2018
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	*Normal pregnancy		===Repeat [[B-hCG]] Levels===
	**[[B-hCG]] ~~should increase~~ >53% in 48hrs (until 10,000 mIU/ml)		{\| {{table}}
	*Ectopic ~~pregnancy~~		\| align="center" style="background:#f0f0f0;"\|'''Pregnancy Type'''
	**[[B-hCG]] increases or decreases slowly ("plateau")^		\| align="center" style="background:#f0f0f0;"\|'''B-hCG Change'''
	*Miscarriage		\|-
	**[[B-hCG]] decreases >20% in 48 hrs		\| Normal\|\|Increase >53% in 48hrs (until 10,000 mIU/ml)
			\|-
			\| Ectopic\|\|Increases or decreases slowly ("plateau")^
			\|-
			\| Miscarriage\|\|Decreases >20% in 48 hrs
			\|}
	^Initial level CANNOT be used to rule-out ectopic		^Initial level CANNOT be used to rule-out ectopic

Rossdonaldson1 at 17:27, 26 October 2014

2014-10-26T17:27:21Z

← Revisión anterior		Revisión del 17:27 26 oct 2014
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	*Normal pregnancy		*Normal pregnancy
	**B-hCG should increase >53% in 48hrs (until 10,000 mIU/ml)		**[[B-hCG]] should increase >53% in 48hrs (until 10,000 mIU/ml)
	*Ectopic pregnancy		*Ectopic pregnancy
	**B-hCG increases or decreases slowly ("plateau")^		**[[B-hCG]] increases or decreases slowly ("plateau")^
	*Miscarriage		*Miscarriage
	**B-hCG decreases >20% in 48 hrs		**[[B-hCG]] decreases >20% in 48 hrs

	^Initial level CANNOT be used to rule-out ectopic		^Initial level CANNOT be used to rule-out ectopic