https://wikem.org/w/index.php?action=history&feed=atom&title=Template%3AAdult_NAC_dosing%2Fen 2026-04-18T22:52:37Z Revision history for this page on the wiki MediaWiki 1.38.2 https://wikem.org/w/index.php?title=Template:Adult_NAC_dosing/en&diff=383480&oldid=prev 2026-01-20T08:16:50Z

<p>Updating to match new version of source page</p> <p><b>Página nueva</b></p><div>&lt;noinclude&gt;&lt;languages/&gt;&lt;/noinclude&gt;<br /> <br /> ====PO====<br /> <br /> *Less preferred than IV route due to unpleasant taste and smell<br /> *140 mg/kg PO load<br /> *70 mg/kg PO q4hr x17 doses additional; dilute to 5% soln<br /> <br /> <br /> ====IV====<br /> <br /> *Loading dose: 150mg/kg in 100 mL D5W over 60min<br /> *Second (maintenance) dose: 50mg/kg in 250 mL D5W over 4hr<br /> *Third dose: 100mg/kg in 500 mL D5W over 16hr<br /> <br /> <br /> ====Comments====<br /> <br /> *Almost 100% effective if given &lt;8 hr post-ingestion; less effective if 16-24 hr post-ingestion<br /> *May still be useful &gt;24 hr post-ingestion, even with fulminant hepatic failure. Give NAC until LFTs improve (not until APAP level is 0) &lt;ref&gt;Keays R, Harrison PM, Wendon JA, et al. Intravenous acetylcysteine in paracetamol-induced fulminant hepatic failure: a prospective controlled trial. BMJ. 1991;303(6809):1026-1029. (Prospective randomized controlled trial; 50 patients)&lt;/ref&gt; &lt;ref&gt;Harrison PM, Keays R, Bray GP, et al. Improved outcome of paracetamol-induced fulminant hepatic failure by late administration of N-acetylcysteine. Lancet. 1990;335(8705):1572- 1573. (Retrospective analysis; 100 patients)&lt;/ref&gt;<br /> *Be aware NAC treatment may affect PT. May see a dose-dependent increase in PT following NAC in patients without hepatotoxicity. &lt;ref&gt;Wasserman GS, Garg U. Intravenous administration of Nacetylcysteine: interference with coagulopathy testing. Ann Emerg Med. 2004;44(5):546-547. (Letter)&lt;/ref&gt;</div>

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